ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)

2006-10-01  

Identity

HGNC
LOCATION
Xq26.3
LOCUSID
ALIAS
COOL2,Cool-2,MRX46,PIXA,alpha-PIX,alphaPIX
FUSION GENES

Other Information

Locus ID:

NCBI: 9459
MIM: 300267
HGNC: 685
Ensembl: ENSG00000129675

Variants:

dbSNP: 9459
ClinVar: 9459
TCGA: ENSG00000129675
COSMIC: ARHGEF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129675ENST00000250617Q15052
ENSG00000129675ENST00000370620Q15052
ENSG00000129675ENST00000370622Q15052

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Pancreatic cancerKEGGko05212
Regulation of actin cytoskeletonKEGGhsa04810
Pancreatic cancerKEGGhsa05212
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-extracellular matrix interactionsREACTOMER-HSA-446353
Regulation of cytoskeletal remodeling and cell spreading by IPP complex componentsREACTOMER-HSA-446388

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119374912002The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.41
271820612016Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.27
168977552006PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation.25
163200262006Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin.20
156111362005AlphaPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading.17
199182612010Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells.13
152425522004Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway.12
129358972003The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.9
199693082010alpha Pix enhances mutant huntingtin aggregation.8
265076612015Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.7

Citation

Dessen P

ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43152/arhgef6