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ARID3A (AT-rich interaction domain 3A)

Identity

Alias_namesDRIL1
dead ringer-like 1 (Drosophila)
AT rich interactive domain 3A (BRIGHT- like)
AT rich interactive domain 3A (BRIGHT-like)
Alias_symbol (synonym)BRIGHT
Other aliasDRIL3
E2FBP1
HGNC (Hugo) ARID3A
LocusID (NCBI) 1820
Atlas_Id 45573
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 926037 and ends at 972803 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARID3A (19p13.3) / PMEPA1 (20q13.31)ARID3A 19p13.3 / PMEPA1 20q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;14)(q24;q32) IGH/MIR125B1


External links

Nomenclature
HGNC (Hugo)ARID3A   3031
Cards
Entrez_Gene (NCBI)ARID3A  1820  AT-rich interaction domain 3A
AliasesBRIGHT; DRIL1; DRIL3; E2FBP1
GeneCards (Weizmann)ARID3A
Ensembl hg19 (Hinxton)ENSG00000116017 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116017 [Gene_View]  chr19:926037-972803 [Contig_View]  ARID3A [Vega]
ICGC DataPortalENSG00000116017
TCGA cBioPortalARID3A
AceView (NCBI)ARID3A
Genatlas (Paris)ARID3A
WikiGenes1820
SOURCE (Princeton)ARID3A
Genetics Home Reference (NIH)ARID3A
Genomic and cartography
GoldenPath hg38 (UCSC)ARID3A  -     chr19:926037-972803 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARID3A  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblARID3A - 19p13.3 [CytoView hg19]  ARID3A - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIARID3A [Mapview hg19]  ARID3A [Mapview hg38]
OMIM603265   
Gene and transcription
Genbank (Entrez)AY152547 AY845638 BC007077 BC010544 BC033163
RefSeq transcript (Entrez)NM_005224
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARID3A
Cluster EST : UnigeneHs.660769 [ NCBI ]
CGAP (NCI)Hs.660769
Alternative Splicing GalleryENSG00000116017
Gene ExpressionARID3A [ NCBI-GEO ]   ARID3A [ EBI - ARRAY_EXPRESS ]   ARID3A [ SEEK ]   ARID3A [ MEM ]
Gene Expression Viewer (FireBrowse)ARID3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1820
GTEX Portal (Tissue expression)ARID3A
Human Protein AtlasENSG00000116017-ARID3A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99856   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99856  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99856
Splice isoforms : SwissVarQ99856
PhosPhoSitePlusQ99856
Domaine pattern : Prosite (Expaxy)ARID (PS51011)    REKLES (PS51486)   
Domains : Interpro (EBI)ARID_dom    REKLES_domain   
Domain families : Pfam (Sanger)ARID (PF01388)   
Domain families : Pfam (NCBI)pfam01388   
Domain families : Smart (EMBL)BRIGHT (SM00501)  
Conserved Domain (NCBI)ARID3A
DMDM Disease mutations1820
Blocks (Seattle)ARID3A
PDB (SRS)2KK0    4LJX   
PDB (PDBSum)2KK0    4LJX   
PDB (IMB)2KK0    4LJX   
PDB (RSDB)2KK0    4LJX   
Structural Biology KnowledgeBase2KK0    4LJX   
SCOP (Structural Classification of Proteins)2KK0    4LJX   
CATH (Classification of proteins structures)2KK0    4LJX   
SuperfamilyQ99856
Human Protein Atlas [tissue]ENSG00000116017-ARID3A [tissue]
Peptide AtlasQ99856
HPRD10343
IPIIPI00018500   
Protein Interaction databases
DIP (DOE-UCLA)Q99856
IntAct (EBI)Q99856
FunCoupENSG00000116017
BioGRIDARID3A
STRING (EMBL)ARID3A
ZODIACARID3A
Ontologies - Pathways
QuickGOQ99856
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  chromatin binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  transcription from RNA polymerase II promoter  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  protein homodimerization activity  intracellular membrane-bounded organelle  membrane raft  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  chromatin binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  transcription from RNA polymerase II promoter  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  protein homodimerization activity  intracellular membrane-bounded organelle  membrane raft  positive regulation of transcription from RNA polymerase II promoter  
NDEx NetworkARID3A
Atlas of Cancer Signalling NetworkARID3A
Wikipedia pathwaysARID3A
Orthology - Evolution
OrthoDB1820
GeneTree (enSembl)ENSG00000116017
Phylogenetic Trees/Animal Genes : TreeFamARID3A
HOVERGENQ99856
HOGENOMQ99856
Homologs : HomoloGeneARID3A
Homology/Alignments : Family Browser (UCSC)ARID3A
Gene fusions - Rearrangements
Fusion : MitelmanARID3A/PMEPA1 [19p13.3/20q13.31]  
Fusion: TCGA_MDACCARID3A 19p13.3 PMEPA1 20q13.31 BRCA
Tumor Fusion PortalARID3A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARID3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARID3A
dbVarARID3A
ClinVarARID3A
1000_GenomesARID3A 
Exome Variant ServerARID3A
ExAC (Exome Aggregation Consortium)ENSG00000116017
GNOMAD BrowserENSG00000116017
Genetic variants : HAPMAP1820
Genomic Variants (DGV)ARID3A [DGVbeta]
DECIPHERARID3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARID3A 
Mutations
ICGC Data PortalARID3A 
TCGA Data PortalARID3A 
Broad Tumor PortalARID3A
OASIS PortalARID3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARID3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARID3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARID3A
DgiDB (Drug Gene Interaction Database)ARID3A
DoCM (Curated mutations)ARID3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARID3A (select a term)
intoGenARID3A
Cancer3DARID3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603265   
Orphanet
DisGeNETARID3A
MedgenARID3A
Genetic Testing Registry ARID3A
NextProtQ99856 [Medical]
TSGene1820
GENETestsARID3A
Target ValidationARID3A
Huge Navigator ARID3A [HugePedia]
snp3D : Map Gene to Disease1820
BioCentury BCIQARID3A
ClinGenARID3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1820
Chemical/Pharm GKB GenePA27485
Clinical trialARID3A
Miscellaneous
canSAR (ICR)ARID3A (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARID3A
EVEXARID3A
GoPubMedARID3A
iHOPARID3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:03:43 CET 2017

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