ARID4A (AT-rich interaction domain 4A)

2003-02-01  

Identity

HGNC
LOCATION
14q23.1
LOCUSID
ALIAS
RBBP-1,RBBP1,RBP-1,RBP1
FUSION GENES

Other Information

Locus ID:

NCBI: 5926
MIM: 180201
HGNC: 9885
Ensembl: ENSG00000032219

Variants:

dbSNP: 5926
ClinVar: 5926
TCGA: ENSG00000032219
COSMIC: ARID4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000032219ENST00000348476P29374
ENSG00000032219ENST00000348476A0A024R680
ENSG00000032219ENST00000355431P29374
ENSG00000032219ENST00000355431A0A024R657
ENSG00000032219ENST00000395168P29374
ENSG00000032219ENST00000395168A0A024R6A2
ENSG00000032219ENST00000417477H7C485
ENSG00000032219ENST00000424658C9JIF4
ENSG00000032219ENST00000431317P29374
ENSG00000032219ENST00000431317A0A024R680
ENSG00000032219ENST00000431612F8WAR5
ENSG00000032219ENST00000445108C9J1W3

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

References

Pubmed IDYearTitleCitations
145814782004Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.73
182119002008Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.33
168733702006Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements.11
222475512012Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1.5
227321862012Reactive oxygen species mediate microRNA-302 regulation of AT-rich interacting domain 4a and C-C motif ligand 5 expression during transitions between quiescence and proliferation.4
243793992014Retinoblastoma-binding protein 1 has an interdigitated double Tudor domain with DNA binding activity.3
294085272018Crystal structure of chromo barrel domain of RBBP1.0
297976002018Downregulation of ARID4A and ARID4B promote tumor progression and directly regulated by microRNA-30d in patient with prostate cancer.0

Citation

Dessen P

ARID4A (AT-rich interaction domain 4A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/703/arid4a