ARID4B (AT-rich interaction domain 4B)

2003-06-01  

Identity

HGNC
ARID4B
LOCATION
1q42.3
LOCUSID
51742
ALIAS
BCAA,BRCAA1,RBBP1L1,RBP1L1,SAP180
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51742
MIM: 609696
HGNC: 15550
Ensembl: ENSG00000054267

Variants:

dbSNP: 51742
ClinVar: 51742
TCGA: ENSG00000054267
COSMIC: ARID4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000054267ENST00000264183Q4LE39
ENSG00000054267ENST00000264183A0A024R3R1
ENSG00000054267ENST00000349213Q4LE39
ENSG00000054267ENST00000366603Q4LE39
ENSG00000054267ENST00000366603A0A024R3R1
ENSG00000054267ENST00000418304X6RCR8
ENSG00000054267ENST00000421364Q4LE39
ENSG00000054267ENST00000444620H0Y7Y8
ENSG00000054267ENST00000474953H7C5R6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
203472652010MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia.34
226934532012Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis.21
152471242004Characterization of BRCAA1 and its novel antigen epitope identification.11
257045702015Novel serum biomarkers for detection of excessive alcohol use.8
294778682018miR-519b-3p promotes responsiveness to preoperative chemoradiotherapy in rectal cancer patients by targeting ARID4B.6
274514342017ARID4B is a good biomarker to predict tumour behaviour and decide WHO grades in gliomas and meningiomas.5
292880402018Overexpression of ARID4B predicts poor survival in patients with hepatocellular carcinoma.2
297976002018Downregulation of ARID4A and ARID4B promote tumor progression and directly regulated by microRNA-30d in patient with prostate cancer.0

Citation

Dessen P

ARID4B (AT-rich interaction domain 4B)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/704/arid4b