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ARID4B (AT-rich interaction domain 4B)

Identity

Alias_namesRBP1L1
retinoblastoma binding protein 1-like 1
AT rich interactive domain 4B (RBP1- like)
AT rich interactive domain 4B (RBP1-like)
Alias_symbol (synonym)BCAA
BRCAA1
SAP180
Other aliasRBBP1L1
HGNC (Hugo) ARID4B
LocusID (NCBI) 51742
Atlas_Id 704
Location 1q42.3  [Link to chromosome band 1q42]
Location_base_pair Starts at 235166895 and ends at 235328217 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARID4B (1q42.3) / ALB (4q13.3)ARID4B (1q42.3) / ARID4B (1q42.3)ARID4B (1q42.3) / B3GALNT2 (1q42.3)
ARID4B (1q42.3) / BCL6 (3q27.3)ARID4B (1q42.3) / DDX21 (10q22.1)ARID4B (1q42.3) / GGPS1 (1q42.3)
ARID4B (1q42.3) / GNPAT (1q42.2)ARID4B (1q42.3) / ING3 (7q31.31)ARID4B (1q42.3) / NTPCR (1q42.2)
ARID4B (1q42.3) / PCNX2 (1q42.2)ARID4B (1q42.3) / RPS6KC1 (1q32.3)ARID4B (1q42.3) / SLC4A7 (3p24.1)
ARID4B (1q42.3) / TM9SF2 (13q32.3)DNAJC7 (17q21.2) / ARID4B (1q42.3)GDF15 (19p13.11) / ARID4B (1q42.3)
ARID4B 1q42.3 / B3GALNT2 1q42.3ARID4B 1q42.3 / GNPAT 1q42.2ARID4B 1q42.3 / NTPCR 1q42.2
ARID4B 1q42.3 / PCNXL2 1q42.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  inv(1)(q32q42) ARID4B/RPS6KC1
t(1;7)(q42;q31) ARID4B/ING3

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  ARID4B/B3GALNT2 (1q42)
ARID4B/GNPAT (1q42)
ARID4B/NTPCR (1q42)

External links

Nomenclature
HGNC (Hugo)ARID4B   15550
Cards
Entrez_Gene (NCBI)ARID4B  51742  AT-rich interaction domain 4B
AliasesBCAA; BRCAA1; RBBP1L1; RBP1L1; 
SAP180
GeneCards (Weizmann)ARID4B
Ensembl hg19 (Hinxton)ENSG00000054267 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000054267 [Gene_View]  ENSG00000054267 [Sequence]  chr1:235166895-235328217 [Contig_View]  ARID4B [Vega]
ICGC DataPortalENSG00000054267
TCGA cBioPortalARID4B
AceView (NCBI)ARID4B
Genatlas (Paris)ARID4B
WikiGenes51742
SOURCE (Princeton)ARID4B
Genetics Home Reference (NIH)ARID4B
Genomic and cartography
GoldenPath hg38 (UCSC)ARID4B  -     chr1:235166895-235328217 -  1q42.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARID4B  -     1q42.3   [Description]    (hg19-Feb_2009)
GoldenPathARID4B - 1q42.3 [CytoView hg19]  ARID4B - 1q42.3 [CytoView hg38]
ImmunoBaseENSG00000054267
Mapping of homologs : NCBIARID4B [Mapview hg19]  ARID4B [Mapview hg38]
OMIM609696   
Gene and transcription
Genbank (Entrez)AB210032 AF083249 AF208045 AF214114 AF227899
RefSeq transcript (Entrez)NM_001206794 NM_016374 NM_031371
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARID4B
Cluster EST : UnigeneHs.575782 [ NCBI ]
CGAP (NCI)Hs.575782
Alternative Splicing GalleryENSG00000054267
Gene ExpressionARID4B [ NCBI-GEO ]   ARID4B [ EBI - ARRAY_EXPRESS ]   ARID4B [ SEEK ]   ARID4B [ MEM ]
Gene Expression Viewer (FireBrowse)ARID4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51742
GTEX Portal (Tissue expression)ARID4B
Human Protein AtlasENSG00000054267-ARID4B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4LE39   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4LE39  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4LE39
Splice isoforms : SwissVarQ4LE39
PhosPhoSitePlusQ4LE39
Domaine pattern : Prosite (Expaxy)ARID (PS51011)   
Domains : Interpro (EBI)ARID4B    ARID_dom    ARID_dom_sf    Chromo-like_dom_sf    Chromo/chromo_shadow_dom    RBB1NT    Tudor    Tudor-knot   
Domain families : Pfam (Sanger)ARID (PF01388)    RBB1NT (PF08169)    Tudor-knot (PF11717)   
Domain families : Pfam (NCBI)pfam01388    pfam08169    pfam11717   
Domain families : Smart (EMBL)BRIGHT (SM00501)  TUDOR (SM00333)  
Conserved Domain (NCBI)ARID4B
DMDM Disease mutations51742
Blocks (Seattle)ARID4B
SuperfamilyQ4LE39
Human Protein Atlas [tissue]ENSG00000054267-ARID4B [tissue]
Peptide AtlasQ4LE39
HPRD10661
IPIIPI00328828   IPI00302917   IPI00647647   IPI00647132   IPI00939705   IPI00879653   IPI00945144   
Protein Interaction databases
DIP (DOE-UCLA)Q4LE39
IntAct (EBI)Q4LE39
FunCoupENSG00000054267
BioGRIDARID4B
STRING (EMBL)ARID4B
ZODIACARID4B
Ontologies - Pathways
QuickGOQ4LE39
Ontology : AmiGODNA-binding transcription factor activity, RNA polymerase II-specific  molecular_function  protein binding  cellular_component  nucleus  nucleoplasm  cytoplasm  regulation of gene expression by genetic imprinting  regulation of transcription by RNA polymerase II  spermatogenesis  biological_process  histone H4-K20 trimethylation  histone H3-K9 trimethylation  transcription regulatory region DNA binding  positive regulation of transcription by RNA polymerase II  establishment of Sertoli cell barrier  
Ontology : EGO-EBIDNA-binding transcription factor activity, RNA polymerase II-specific  molecular_function  protein binding  cellular_component  nucleus  nucleoplasm  cytoplasm  regulation of gene expression by genetic imprinting  regulation of transcription by RNA polymerase II  spermatogenesis  biological_process  histone H4-K20 trimethylation  histone H3-K9 trimethylation  transcription regulatory region DNA binding  positive regulation of transcription by RNA polymerase II  establishment of Sertoli cell barrier  
NDEx NetworkARID4B
Atlas of Cancer Signalling NetworkARID4B
Wikipedia pathwaysARID4B
Orthology - Evolution
OrthoDB51742
GeneTree (enSembl)ENSG00000054267
Phylogenetic Trees/Animal Genes : TreeFamARID4B
HOGENOMQ4LE39
Homologs : HomoloGeneARID4B
Homology/Alignments : Family Browser (UCSC)ARID4B
Gene fusions - Rearrangements
Fusion : MitelmanARID4B/B3GALNT2 [1q42.3/1q42.3]  
Fusion : MitelmanARID4B/GNPAT [1q42.3/1q42.2]  [t(1;1)(q42;q42)]  
Fusion : MitelmanARID4B/ING3 [1q42.3/7q31.31]  [t(1;7)(q42;q31)]  
Fusion : MitelmanARID4B/NTPCR [1q42.3/1q42.2]  [t(1;1)(q42;q42)]  
Fusion : MitelmanARID4B/PCNXL2 [1q42.3/1q42.2]  [t(1;1)(q42;q42)]  
Fusion : MitelmanARID4B/RPS6KC1 [1q42.3/1q32.3]  [inv(1)(q32q42)]  
Fusion PortalARID4B 1q42.3 B3GALNT2 1q42.3 BRCA
Fusion PortalARID4B 1q42.3 GNPAT 1q42.2 OV
Fusion PortalARID4B 1q42.3 NTPCR 1q42.2 BLCA
Fusion PortalARID4B 1q42.3 PCNXL2 1q42.2 BRCA
Fusion : QuiverARID4B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARID4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARID4B
dbVarARID4B
ClinVarARID4B
1000_GenomesARID4B 
Exome Variant ServerARID4B
ExAC (Exome Aggregation Consortium)ENSG00000054267
GNOMAD BrowserENSG00000054267
Varsome BrowserARID4B
Genetic variants : HAPMAP51742
Genomic Variants (DGV)ARID4B [DGVbeta]
DECIPHERARID4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARID4B 
Mutations
ICGC Data PortalARID4B 
TCGA Data PortalARID4B 
Broad Tumor PortalARID4B
OASIS PortalARID4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARID4B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARID4B
Mutations and Diseases : HGMDARID4B
intOGen PortalARID4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARID4B
DgiDB (Drug Gene Interaction Database)ARID4B
DoCM (Curated mutations)ARID4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARID4B (select a term)
intoGenARID4B
Cancer3DARID4B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609696   
Orphanet
DisGeNETARID4B
MedgenARID4B
Genetic Testing Registry ARID4B
NextProtQ4LE39 [Medical]
TSGene51742
GENETestsARID4B
Target ValidationARID4B
Huge Navigator ARID4B [HugePedia]
snp3D : Map Gene to Disease51742
BioCentury BCIQARID4B
ClinGenARID4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51742
Chemical/Pharm GKB GenePA134940494
Clinical trialARID4B
Miscellaneous
canSAR (ICR)ARID4B (select the gene name)
DataMed IndexARID4B
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARID4B
EVEXARID4B
GoPubMedARID4B
iHOPARID4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:32:58 CET 2019
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