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ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2)

Identity

Alias (NCBI)ARI2
TRIAD1
HGNC (Hugo) ARIH2
HGNC Alias symbTRIAD1
HGNC Alias nameall-trans retinoic acid inducible RING finger
HGNC Previous nameariadne (Drosophila) homolog 2
 ariadne homolog 2 (Drosophila)
LocusID (NCBI) 10425
Atlas_Id 54134
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 48918842 and ends at 48986382 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARIH2 (3p21.31) / ARIH2 (3p21.31)ARIH2 (3p21.31) / CAMP (3p21.31)ARIH2 (3p21.31) / DHX30 (3p21.31)
ARIH2 (3p21.31) / RHOA (3p21.31)ARIH2 (3p21.31) / SLC25A20 (3p21.31)ARIH2 (3p21.31) / TOX3 (16q12.1)
ARIH2 (3p21.31) / TRIO (5p15.2)HLA-DRB1 (6p21.32) / ARIH2 (3p21.31)NCL (2q37.1) / ARIH2 (3p21.31)
PAG1 (8q21.13) / ARIH2 (3p21.31)RBM6 (3p21.31) / ARIH2 (3p21.31)TCTA (3p21.31) / ARIH2 (3p21.31)
TMEM119 (12q23.3) / ARIH2 (3p21.31)TOX3 (16q12.1) / ARIH2 (3p21.31)ARIH2 3p21.31 / CAMP 3p21.31
ARIH2 3p21.31 / DHX30 3p21.31ARIH2 3p21.31 / RHOA 3p21.31ARIH2 3p21.31 / SLC25A20 3p21.31
ARIH2 3p21.31 / TRIO 5p15.2RBM6 3p21.31 / ARIH2 3p21.31TCTA 3p21.31 / ARIH2 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ARIH2   690
Cards
Entrez_Gene (NCBI)ARIH2    ariadne RBR E3 ubiquitin protein ligase 2
AliasesARI2; TRIAD1
GeneCards (Weizmann)ARIH2
Ensembl hg19 (Hinxton)ENSG00000177479 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177479 [Gene_View]  ENSG00000177479 [Sequence]  chr3:48918842-48986382 [Contig_View]  ARIH2 [Vega]
ICGC DataPortalENSG00000177479
TCGA cBioPortalARIH2
AceView (NCBI)ARIH2
Genatlas (Paris)ARIH2
SOURCE (Princeton)ARIH2
Genetics Home Reference (NIH)ARIH2
Genomic and cartography
GoldenPath hg38 (UCSC)ARIH2  -     chr3:48918842-48986382 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARIH2  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathARIH2 - 3p21.31 [CytoView hg19]  ARIH2 - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000177479
Genome Data Viewer NCBIARIH2 [Mapview hg19]  
OMIM605615   
Gene and transcription
Genbank (Entrez)AB208857 AF099149 AF099150 AF099151 AF099152
RefSeq transcript (Entrez)NM_001317333 NM_001317334 NM_001349209 NM_001349210 NM_001349211 NM_001349212 NM_001349213 NM_001349214 NM_001349215 NM_001349216 NM_001349217 NM_001349218 NM_001349219 NM_001349220 NM_001349221 NM_001349222 NM_001349223 NM_001349224 NM_001349225 NM_001349226 NM_001349227 NM_001349228 NM_001349229 NM_001349230 NM_006321
Consensus coding sequences : CCDS (NCBI)ARIH2
Gene ExpressionARIH2 [ NCBI-GEO ]   ARIH2 [ EBI - ARRAY_EXPRESS ]   ARIH2 [ SEEK ]   ARIH2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARIH2 [ Firebrowse - Broad ]
GenevisibleExpression of ARIH2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10425
GTEX Portal (Tissue expression)ARIH2
Human Protein AtlasENSG00000177479-ARIH2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95376   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95376  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95376
PhosPhoSitePlusO95376
Domaine pattern : Prosite (Expaxy)TRIAD (PS51873)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Ariadne-2    E3_UB_ligase_RBR    IBR_dom    TRIAD_supradom    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)IBR (PF01485)   
Domain families : Pfam (NCBI)pfam01485   
Domain families : Smart (EMBL)IBR (SM00647)  RING (SM00184)  
Conserved Domain (NCBI)ARIH2
SuperfamilyO95376
AlphaFold pdb e-kbO95376   
Human Protein Atlas [tissue]ENSG00000177479-ARIH2 [tissue]
HPRD09286
Protein Interaction databases
DIP (DOE-UCLA)O95376
IntAct (EBI)O95376
BioGRIDARIH2
STRING (EMBL)ARIH2
ZODIACARIH2
Ontologies - Pathways
QuickGOO95376
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  multicellular organism development  zinc ion binding  protein ubiquitination  ubiquitin conjugating enzyme binding  ubiquitin conjugating enzyme binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  developmental cell growth  ubiquitin protein ligase activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  hematopoietic stem cell proliferation  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  multicellular organism development  zinc ion binding  protein ubiquitination  ubiquitin conjugating enzyme binding  ubiquitin conjugating enzyme binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  developmental cell growth  ubiquitin protein ligase activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  hematopoietic stem cell proliferation  positive regulation of protein targeting to mitochondrion  
NDEx NetworkARIH2
Atlas of Cancer Signalling NetworkARIH2
Wikipedia pathwaysARIH2
Orthology - Evolution
OrthoDB10425
GeneTree (enSembl)ENSG00000177479
Phylogenetic Trees/Animal Genes : TreeFamARIH2
Homologs : HomoloGeneARIH2
Homology/Alignments : Family Browser (UCSC)ARIH2
Gene fusions - Rearrangements
Fusion : MitelmanARIH2/CAMP [3p21.31/3p21.31]  
Fusion : MitelmanARIH2/DHX30 [3p21.31/3p21.31]  
Fusion : MitelmanARIH2/RHOA [3p21.31/3p21.31]  
Fusion : MitelmanARIH2/SLC25A20 [3p21.31/3p21.31]  
Fusion : MitelmanARIH2/TRIO [3p21.31/5p15.2]  
Fusion : MitelmanRBM6/ARIH2 [3p21.31/3p21.31]  
Fusion : MitelmanTCTA/ARIH2 [3p21.31/3p21.31]  
Fusion : MitelmanTMEM119/ARIH2 [12q23.3/3p21.31]  
Fusion : QuiverARIH2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARIH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARIH2
dbVarARIH2
ClinVarARIH2
MonarchARIH2
1000_GenomesARIH2 
Exome Variant ServerARIH2
GNOMAD BrowserENSG00000177479
Varsome BrowserARIH2
ACMGARIH2 variants
VarityO95376
Genomic Variants (DGV)ARIH2 [DGVbeta]
DECIPHERARIH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARIH2 
Mutations
ICGC Data PortalARIH2 
TCGA Data PortalARIH2 
Broad Tumor PortalARIH2
OASIS PortalARIH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARIH2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARIH2
Mutations and Diseases : HGMDARIH2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARIH2
DgiDB (Drug Gene Interaction Database)ARIH2
DoCM (Curated mutations)ARIH2
CIViC (Clinical Interpretations of Variants in Cancer)ARIH2
Cancer3DARIH2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605615   
Orphanet
DisGeNETARIH2
MedgenARIH2
Genetic Testing Registry ARIH2
NextProtO95376 [Medical]
GENETestsARIH2
Target ValidationARIH2
Huge Navigator ARIH2 [HugePedia]
ClinGenARIH2
Clinical trials, drugs, therapy
MyCancerGenomeARIH2
Protein Interactions : CTDARIH2
Pharm GKB GenePA24983
PharosO95376
Clinical trialARIH2
Miscellaneous
canSAR (ICR)ARIH2
HarmonizomeARIH2
DataMed IndexARIH2
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARIH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:00:06 CEST 2021

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