ARL1 (ADP ribosylation factor like GTPase 1)

2006-10-01  

Identity

HGNC
LOCATION
12q23.2
LOCUSID
ALIAS
ARFL1

Other Information

Locus ID:

NCBI: 400
MIM: 603425
HGNC: 692
Ensembl: ENSG00000120805

Variants:

dbSNP: 400
ClinVar: 400
TCGA: ENSG00000120805
COSMIC: ARL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120805ENST00000261636P40616
ENSG00000120805ENST00000536227P40616
ENSG00000120805ENST00000539055B4DZG7
ENSG00000120805ENST00000548070F8VP99
ENSG00000120805ENST00000551092F8VP63
ENSG00000120805ENST00000551671F8VYN9
ENSG00000120805ENST00000551688F8W1Z8
ENSG00000120805ENST00000551828P40616

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152692792004Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network.66
212394832011Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs.24
248354602014Rab4 orchestrates a small GTPase cascade for recruitment of adaptor proteins to early endosomes.22
233454392013Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p.20
192249222009Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes.18
171276202006Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.17
197034032009The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1.16
226790202012Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.12
273731592016Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.8
315756032019ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.1

Citation

Dessen P

ARL1 (ADP ribosylation factor like GTPase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43155/arl1