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ARL2 (ADP ribosylation factor like GTPase 2)

Identity

Alias (NCBI)ARFL2
MRCS1
HGNC (Hugo) ARL2
HGNC Alias symbARFL2
HGNC Previous nameADP-ribosylation factor-like 2
LocusID (NCBI) 402
Atlas_Id 43156
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65014160 and ends at 65022184 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAPN1 (11q13.1) / ARL2 (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ARL2   693
Cards
Entrez_Gene (NCBI)ARL2    ADP ribosylation factor like GTPase 2
AliasesARFL2; MRCS1
GeneCards (Weizmann)ARL2
Ensembl hg19 (Hinxton)ENSG00000213465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213465 [Gene_View]  ENSG00000213465 [Sequence]  chr11:65014160-65022184 [Contig_View]  ARL2 [Vega]
ICGC DataPortalENSG00000213465
TCGA cBioPortalARL2
AceView (NCBI)ARL2
Genatlas (Paris)ARL2
SOURCE (Princeton)ARL2
Genetics Home Reference (NIH)ARL2
Genomic and cartography
GoldenPath hg38 (UCSC)ARL2  -     chr11:65014160-65022184 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARL2  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathARL2 - 11q13.1 [CytoView hg19]  ARL2 - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000213465
Genome Data Viewer NCBIARL2 [Mapview hg19]  
OMIM601175   619082   
Gene and transcription
Genbank (Entrez)AF493888 AI076058 AI631767 AK223502 AK294580
RefSeq transcript (Entrez)NM_001199745 NM_001667
Consensus coding sequences : CCDS (NCBI)ARL2
Gene ExpressionARL2 [ NCBI-GEO ]   ARL2 [ EBI - ARRAY_EXPRESS ]   ARL2 [ SEEK ]   ARL2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARL2 [ Firebrowse - Broad ]
GenevisibleExpression of ARL2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)402
GTEX Portal (Tissue expression)ARL2
Human Protein AtlasENSG00000213465-ARL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36404   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36404  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36404
PhosPhoSitePlusP36404
Domaine pattern : Prosite (Expaxy)ARF (PS51417)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase_ARF/SAR   
Domain families : Pfam (Sanger)Arf (PF00025)   
Domain families : Pfam (NCBI)pfam00025   
Conserved Domain (NCBI)ARL2
PDB (RSDB)3DOE    3DOF   
PDB Europe3DOE    3DOF   
PDB (PDBSum)3DOE    3DOF   
PDB (IMB)3DOE    3DOF   
Structural Biology KnowledgeBase3DOE    3DOF   
SCOP (Structural Classification of Proteins)3DOE    3DOF   
CATH (Classification of proteins structures)3DOE    3DOF   
SuperfamilyP36404
AlphaFold pdb e-kbP36404   
Human Protein Atlas [tissue]ENSG00000213465-ARL2 [tissue]
HPRD11869
Protein Interaction databases
DIP (DOE-UCLA)P36404
IntAct (EBI)P36404
BioGRIDARL2
STRING (EMBL)ARL2
ZODIACARL2
Ontologies - Pathways
QuickGOP36404
Ontology : AmiGOMAPK cascade  GTPase activity  GTPase inhibitor activity  protein binding  GTP binding  GTP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrial intermembrane space  mitochondrial matrix  Golgi apparatus  centrosome  cytosol  cytosol  focal adhesion  cilium  tubulin complex assembly  centrosome cycle  positive regulation of cell-substrate adhesion  microtubule cytoskeleton  lateral plasma membrane  GDP binding  regulation of microtubule polymerization  positive regulation of microtubule polymerization  positive regulation of microtubule polymerization  negative regulation of GTPase activity  maintenance of protein location in nucleus  bicellular tight junction assembly  
Ontology : EGO-EBIMAPK cascade  GTPase activity  GTPase inhibitor activity  protein binding  GTP binding  GTP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrial intermembrane space  mitochondrial matrix  Golgi apparatus  centrosome  cytosol  cytosol  focal adhesion  cilium  tubulin complex assembly  centrosome cycle  positive regulation of cell-substrate adhesion  microtubule cytoskeleton  lateral plasma membrane  GDP binding  regulation of microtubule polymerization  positive regulation of microtubule polymerization  positive regulation of microtubule polymerization  negative regulation of GTPase activity  maintenance of protein location in nucleus  bicellular tight junction assembly  
NDEx NetworkARL2
Atlas of Cancer Signalling NetworkARL2
Wikipedia pathwaysARL2
Orthology - Evolution
OrthoDB402
GeneTree (enSembl)ENSG00000213465
Phylogenetic Trees/Animal Genes : TreeFamARL2
Homologs : HomoloGeneARL2
Homology/Alignments : Family Browser (UCSC)ARL2
Gene fusions - Rearrangements
Fusion : MitelmanCAPN1/ARL2 [11q13.1/11q13.1]  
Fusion : QuiverARL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARL2
dbVarARL2
ClinVarARL2
MonarchARL2
1000_GenomesARL2 
Exome Variant ServerARL2
GNOMAD BrowserENSG00000213465
Varsome BrowserARL2
ACMGARL2 variants
VarityP36404
Genomic Variants (DGV)ARL2 [DGVbeta]
DECIPHERARL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARL2 
Mutations
ICGC Data PortalARL2 
TCGA Data PortalARL2 
Broad Tumor PortalARL2
OASIS PortalARL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARL2
Mutations and Diseases : HGMDARL2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARL2
DgiDB (Drug Gene Interaction Database)ARL2
DoCM (Curated mutations)ARL2
CIViC (Clinical Interpretations of Variants in Cancer)ARL2
Cancer3DARL2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601175    619082   
Orphanet
DisGeNETARL2
MedgenARL2
Genetic Testing Registry ARL2
NextProtP36404 [Medical]
GENETestsARL2
Target ValidationARL2
Huge Navigator ARL2 [HugePedia]
ClinGenARL2
Clinical trials, drugs, therapy
MyCancerGenomeARL2
Protein Interactions : CTDARL2
Pharm GKB GenePA24986
PharosP36404
Clinical trialARL2
Miscellaneous
canSAR (ICR)ARL2
HarmonizomeARL2
DataMed IndexARL2
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:00:07 CEST 2021

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