ARL2 (ADP ribosylation factor like GTPase 2)

2006-10-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
ARFL2,MRCS1
FUSION GENES

Other Information

Locus ID:

NCBI: 402
MIM: 601175
HGNC: 693
Ensembl: ENSG00000213465

Variants:

dbSNP: 402
ClinVar: 402
TCGA: ENSG00000213465
COSMIC: ARL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213465ENST00000246747P36404
ENSG00000213465ENST00000246747Q53YD8
ENSG00000213465ENST00000529384P36404
ENSG00000213465ENST00000529384Q53YD8
ENSG00000213465ENST00000533729P36404

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220027212011Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.96
165250222006Arl2 and Arl3 regulate different microtubule-dependent processes.75
185888842008Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.30
120159662002The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis.23
238072242013MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells.22
207406042010Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity.21
193688932009Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.20
249112112014The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.20
171882652007ADP ribosylation factor like 2 (Arl2) protein influences microtubule dynamics in breast cancer cells.17
274819432016Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.16

Citation

Dessen P

ARL2 (ADP ribosylation factor like GTPase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43156/arl2