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ARL2 (ADP ribosylation factor like GTPase 2)

Identity

Alias_namesADP-ribosylation factor-like 2
Alias_symbol (synonym)ARFL2
Other alias
HGNC (Hugo) ARL2
LocusID (NCBI) 402
Atlas_Id 43156
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65014113 and ends at 65022185 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAPN1 (11q13.1) / ARL2 (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARL2   693
Cards
Entrez_Gene (NCBI)ARL2  402  ADP ribosylation factor like GTPase 2
AliasesARFL2
GeneCards (Weizmann)ARL2
Ensembl hg19 (Hinxton)ENSG00000213465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213465 [Gene_View]  chr11:65014113-65022185 [Contig_View]  ARL2 [Vega]
ICGC DataPortalENSG00000213465
TCGA cBioPortalARL2
AceView (NCBI)ARL2
Genatlas (Paris)ARL2
WikiGenes402
SOURCE (Princeton)ARL2
Genetics Home Reference (NIH)ARL2
Genomic and cartography
GoldenPath hg38 (UCSC)ARL2  -     chr11:65014113-65022185 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARL2  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblARL2 - 11q13.1 [CytoView hg19]  ARL2 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIARL2 [Mapview hg19]  ARL2 [Mapview hg38]
OMIM601175   
Gene and transcription
Genbank (Entrez)AF493888 AI076058 AI631767 AK223502 AK294580
RefSeq transcript (Entrez)NM_001199745 NM_001667
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARL2
Cluster EST : UnigeneHs.502836 [ NCBI ]
CGAP (NCI)Hs.502836
Alternative Splicing GalleryENSG00000213465
Gene ExpressionARL2 [ NCBI-GEO ]   ARL2 [ EBI - ARRAY_EXPRESS ]   ARL2 [ SEEK ]   ARL2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)402
GTEX Portal (Tissue expression)ARL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36404   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36404  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36404
Splice isoforms : SwissVarP36404
PhosPhoSitePlusP36404
Domaine pattern : Prosite (Expaxy)ARF (PS51417)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase_ARF    Small_GTPase_ARF/SAR   
Domain families : Pfam (Sanger)Arf (PF00025)   
Domain families : Pfam (NCBI)pfam00025   
Conserved Domain (NCBI)ARL2
DMDM Disease mutations402
Blocks (Seattle)ARL2
PDB (SRS)3DOE    3DOF   
PDB (PDBSum)3DOE    3DOF   
PDB (IMB)3DOE    3DOF   
PDB (RSDB)3DOE    3DOF   
Structural Biology KnowledgeBase3DOE    3DOF   
SCOP (Structural Classification of Proteins)3DOE    3DOF   
CATH (Classification of proteins structures)3DOE    3DOF   
SuperfamilyP36404
Human Protein AtlasENSG00000213465
Peptide AtlasP36404
HPRD11869
IPIIPI00003326   IPI00908403   
Protein Interaction databases
DIP (DOE-UCLA)P36404
IntAct (EBI)P36404
FunCoupENSG00000213465
BioGRIDARL2
STRING (EMBL)ARL2
ZODIACARL2
Ontologies - Pathways
QuickGOP36404
Ontology : AmiGOGTPase activity  GTPase inhibitor activity  protein binding  GTP binding  nucleus  nucleolus  mitochondrial intermembrane space  mitochondrial matrix  Golgi apparatus  centrosome  cytosol  cytosol  focal adhesion  cilium  tubulin complex assembly  centrosome cycle  small GTPase mediated signal transduction  positive regulation of cell-substrate adhesion  lateral plasma membrane  GDP binding  regulation of microtubule polymerization  positive regulation of microtubule polymerization  negative regulation of GTPase activity  regulation of insulin secretion  maintenance of protein location in nucleus  extracellular exosome  bicellular tight junction assembly  
Ontology : EGO-EBIGTPase activity  GTPase inhibitor activity  protein binding  GTP binding  nucleus  nucleolus  mitochondrial intermembrane space  mitochondrial matrix  Golgi apparatus  centrosome  cytosol  cytosol  focal adhesion  cilium  tubulin complex assembly  centrosome cycle  small GTPase mediated signal transduction  positive regulation of cell-substrate adhesion  lateral plasma membrane  GDP binding  regulation of microtubule polymerization  positive regulation of microtubule polymerization  negative regulation of GTPase activity  regulation of insulin secretion  maintenance of protein location in nucleus  extracellular exosome  bicellular tight junction assembly  
NDEx NetworkARL2
Atlas of Cancer Signalling NetworkARL2
Wikipedia pathwaysARL2
Orthology - Evolution
OrthoDB402
GeneTree (enSembl)ENSG00000213465
Phylogenetic Trees/Animal Genes : TreeFamARL2
HOVERGENP36404
HOGENOMP36404
Homologs : HomoloGeneARL2
Homology/Alignments : Family Browser (UCSC)ARL2
Gene fusions - Rearrangements
Fusion : MitelmanCAPN1/ARL2 [11q13.1/11q13.1]  [t(11;11)(q13;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARL2
dbVarARL2
ClinVarARL2
1000_GenomesARL2 
Exome Variant ServerARL2
ExAC (Exome Aggregation Consortium)ARL2 (select the gene name)
Genetic variants : HAPMAP402
Genomic Variants (DGV)ARL2 [DGVbeta]
DECIPHERARL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARL2 
Mutations
ICGC Data PortalARL2 
TCGA Data PortalARL2 
Broad Tumor PortalARL2
OASIS PortalARL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARL2
DgiDB (Drug Gene Interaction Database)ARL2
DoCM (Curated mutations)ARL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARL2 (select a term)
intoGenARL2
Cancer3DARL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601175   
Orphanet
MedgenARL2
Genetic Testing Registry ARL2
NextProtP36404 [Medical]
TSGene402
GENETestsARL2
Target ValidationARL2
Huge Navigator ARL2 [HugePedia]
snp3D : Map Gene to Disease402
BioCentury BCIQARL2
ClinGenARL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD402
Chemical/Pharm GKB GenePA24986
Clinical trialARL2
Miscellaneous
canSAR (ICR)ARL2 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARL2
EVEXARL2
GoPubMedARL2
iHOPARL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:55:26 CEST 2017

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