Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ARL3 (ADP ribosylation factor like GTPase 3)

Identity

Alias (NCBI)ARFL3
JBTS35
RP83
HGNC (Hugo) ARL3
HGNC Alias symbARFL3
HGNC Previous nameADP-ribosylation factor-like 3
LocusID (NCBI) 403
Atlas_Id 706
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 102673731 and ends at 102714397 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARL3 (10q24.32) / ACO1 (9p21.1)ARL3 (10q24.32) / ACTR1A (10q24.32)MTF2 (1p22.1) / ARL3 (10q24.32)
WBP1L (10q24.32) / ARL3 (10q24.32)C10orf26 ARL3 10q24.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ARL3   694
Cards
Entrez_Gene (NCBI)ARL3    ADP ribosylation factor like GTPase 3
AliasesARFL3; JBTS35; RP83
GeneCards (Weizmann)ARL3
Ensembl hg19 (Hinxton)ENSG00000138175 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138175 [Gene_View]  ENSG00000138175 [Sequence]  chr10:102673731-102714397 [Contig_View]  ARL3 [Vega]
ICGC DataPortalENSG00000138175
TCGA cBioPortalARL3
AceView (NCBI)ARL3
Genatlas (Paris)ARL3
SOURCE (Princeton)ARL3
Genetics Home Reference (NIH)ARL3
Genomic and cartography
GoldenPath hg38 (UCSC)ARL3  -     chr10:102673731-102714397 -  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARL3  -     10q24.32   [Description]    (hg19-Feb_2009)
GoldenPathARL3 - 10q24.32 [CytoView hg19]  ARL3 - 10q24.32 [CytoView hg38]
ImmunoBaseENSG00000138175
Genome Data Viewer NCBIARL3 [Mapview hg19]  
OMIM604695   618161   618173   
Gene and transcription
Genbank (Entrez)AA325516 AF038193 AF493889 AK312525 AW269939
RefSeq transcript (Entrez)NM_004311
Consensus coding sequences : CCDS (NCBI)ARL3
Gene ExpressionARL3 [ NCBI-GEO ]   ARL3 [ EBI - ARRAY_EXPRESS ]   ARL3 [ SEEK ]   ARL3 [ MEM ]
Gene Expression Viewer (FireBrowse)ARL3 [ Firebrowse - Broad ]
GenevisibleExpression of ARL3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)403
GTEX Portal (Tissue expression)ARL3
Human Protein AtlasENSG00000138175-ARL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36405   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36405  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36405
PhosPhoSitePlusP36405
Domaine pattern : Prosite (Expaxy)ARF (PS51417)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase_ARF/SAR   
Domain families : Pfam (Sanger)Arf (PF00025)   
Domain families : Pfam (NCBI)pfam00025   
Conserved Domain (NCBI)ARL3
SuperfamilyP36405
AlphaFold pdb e-kbP36405   
Human Protein Atlas [tissue]ENSG00000138175-ARL3 [tissue]
HPRD05260
Protein Interaction databases
DIP (DOE-UCLA)P36405
IntAct (EBI)P36405
BioGRIDARL3
STRING (EMBL)ARL3
ZODIACARL3
Ontologies - Pathways
QuickGOP36405
Ontology : AmiGOGolgi membrane  mitotic cytokinesis  magnesium ion binding  kidney development  GTPase activity  protein binding  GTP binding  GTP binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  centrosome  spindle microtubule  cytoplasmic microtubule  cilium  cilium  cilium  post-Golgi vesicle-mediated transport  Golgi to plasma membrane transport  smoothened signaling pathway  small GTPase mediated signal transduction  microtubule binding  protein transport  microtubule cytoskeleton  GDP binding  midbody  positive regulation of microtubule polymerization  photoreceptor connecting cilium  GTPase activating protein binding  intraciliary transport  photoreceptor cell development  cilium assembly  cilium assembly  cilium assembly  protein localization to cilium  extracellular exosome  protein localization to ciliary membrane  
Ontology : EGO-EBIGolgi membrane  mitotic cytokinesis  magnesium ion binding  kidney development  GTPase activity  protein binding  GTP binding  GTP binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  centrosome  spindle microtubule  cytoplasmic microtubule  cilium  cilium  cilium  post-Golgi vesicle-mediated transport  Golgi to plasma membrane transport  smoothened signaling pathway  small GTPase mediated signal transduction  microtubule binding  protein transport  microtubule cytoskeleton  GDP binding  midbody  positive regulation of microtubule polymerization  photoreceptor connecting cilium  GTPase activating protein binding  intraciliary transport  photoreceptor cell development  cilium assembly  cilium assembly  cilium assembly  protein localization to cilium  extracellular exosome  protein localization to ciliary membrane  
NDEx NetworkARL3
Atlas of Cancer Signalling NetworkARL3
Wikipedia pathwaysARL3
Orthology - Evolution
OrthoDB403
GeneTree (enSembl)ENSG00000138175
Phylogenetic Trees/Animal Genes : TreeFamARL3
Homologs : HomoloGeneARL3
Homology/Alignments : Family Browser (UCSC)ARL3
Gene fusions - Rearrangements
Fusion : MitelmanARL3/ACO1 [10q24.32/9p21.1]  
Fusion : MitelmanMTF2/ARL3 [1p22.1/10q24.32]  
Fusion : MitelmanWBP1L/ARL3 [10q24.32/10q24.32]  
Fusion : QuiverARL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARL3
dbVarARL3
ClinVarARL3
MonarchARL3
1000_GenomesARL3 
Exome Variant ServerARL3
GNOMAD BrowserENSG00000138175
Varsome BrowserARL3
ACMGARL3 variants
VarityP36405
Genomic Variants (DGV)ARL3 [DGVbeta]
DECIPHERARL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARL3 
Mutations
ICGC Data PortalARL3 
TCGA Data PortalARL3 
Broad Tumor PortalARL3
OASIS PortalARL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARL3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARL3
Mutations and Diseases : HGMDARL3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARL3
DgiDB (Drug Gene Interaction Database)ARL3
DoCM (Curated mutations)ARL3
CIViC (Clinical Interpretations of Variants in Cancer)ARL3
Cancer3DARL3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604695    618161    618173   
Orphanet
DisGeNETARL3
MedgenARL3
Genetic Testing Registry ARL3
NextProtP36405 [Medical]
GENETestsARL3
Target ValidationARL3
Huge Navigator ARL3 [HugePedia]
ClinGenARL3
Clinical trials, drugs, therapy
MyCancerGenomeARL3
Protein Interactions : CTDARL3
Pharm GKB GenePA24987
PharosP36405
Clinical trialARL3
Miscellaneous
canSAR (ICR)ARL3
HarmonizomeARL3
DataMed IndexARL3
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:00:07 CEST 2021

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