ARL3 (ADP ribosylation factor like GTPase 3)

2003-11-01  

Identity

HGNC
ARL3
LOCATION
10q24.32
LOCUSID
403
ALIAS
ARFL3,JBTS35,RP83
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 403
MIM: 604695
HGNC: 694
Ensembl: ENSG00000138175

Variants:

dbSNP: 403
ClinVar: 403
TCGA: ENSG00000138175
COSMIC: ARL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138175ENST00000260746P36405

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
Trafficking of myristoylated proteins to the ciliumREACTOMER-HSA-5624138

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
220027212011Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.96
165250222006Arl2 and Arl3 regulate different microtubule-dependent processes.75
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
201068692010The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium.50
229606332012Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.47
185888842008Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.30
235486552013Molecular views of Arf-like small GTPases in cilia and ciliopathies.20
269368252016ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.19
274819432016Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.16
284873612017Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).15

Citation

Dessen P

ARL3 (ADP ribosylation factor like GTPase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/706/arl3