Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ARL6 (ADP ribosylation factor like GTPase 6)

Identity

Alias_namesBBS3
ADP-ribosylation factor-like 6
Alias_symbol (synonym)RP55
Other alias
HGNC (Hugo) ARL6
LocusID (NCBI) 84100
Atlas_Id 43157
Location 3q11.2  [Link to chromosome band 3q11]
Location_base_pair Starts at 97764521 and ends at 97801242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AC110491.1 () / ARL6 (3q11.2)ARL6 (3q11.2) / KIAA1324L (7q21.12)ZNF660 (3p21.31) / ARL6 (3q11.2)
AC110491.1 ARL6 3q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARL6   13210
Cards
Entrez_Gene (NCBI)ARL6  84100  ADP ribosylation factor like GTPase 6
AliasesBBS3; RP55
GeneCards (Weizmann)ARL6
Ensembl hg19 (Hinxton)ENSG00000113966 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113966 [Gene_View]  chr3:97764521-97801242 [Contig_View]  ARL6 [Vega]
ICGC DataPortalENSG00000113966
TCGA cBioPortalARL6
AceView (NCBI)ARL6
Genatlas (Paris)ARL6
WikiGenes84100
SOURCE (Princeton)ARL6
Genetics Home Reference (NIH)ARL6
Genomic and cartography
GoldenPath hg38 (UCSC)ARL6  -     chr3:97764521-97801242 +  3q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARL6  -     3q11.2   [Description]    (hg19-Feb_2009)
EnsemblARL6 - 3q11.2 [CytoView hg19]  ARL6 - 3q11.2 [CytoView hg38]
Mapping of homologs : NCBIARL6 [Mapview hg19]  ARL6 [Mapview hg38]
OMIM209900   268000   600151   608845   613575   
Gene and transcription
Genbank (Entrez)AK292958 AK310829 AK311281 AL136815 AL138043
RefSeq transcript (Entrez)NM_001278293 NM_001323513 NM_001323514 NM_032146 NM_177976
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARL6
Cluster EST : UnigeneHs.682062 [ NCBI ]
CGAP (NCI)Hs.682062
Alternative Splicing GalleryENSG00000113966
Gene ExpressionARL6 [ NCBI-GEO ]   ARL6 [ EBI - ARRAY_EXPRESS ]   ARL6 [ SEEK ]   ARL6 [ MEM ]
Gene Expression Viewer (FireBrowse)ARL6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84100
GTEX Portal (Tissue expression)ARL6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H0F7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H0F7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H0F7
Splice isoforms : SwissVarQ9H0F7
PhosPhoSitePlusQ9H0F7
Domaine pattern : Prosite (Expaxy)ARF (PS51417)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase_ARF    Small_GTPase_ARF/SAR   
Domain families : Pfam (Sanger)Arf (PF00025)   
Domain families : Pfam (NCBI)pfam00025   
Conserved Domain (NCBI)ARL6
DMDM Disease mutations84100
Blocks (Seattle)ARL6
PDB (SRS)2H57   
PDB (PDBSum)2H57   
PDB (IMB)2H57   
PDB (RSDB)2H57   
Structural Biology KnowledgeBase2H57   
SCOP (Structural Classification of Proteins)2H57   
CATH (Classification of proteins structures)2H57   
SuperfamilyQ9H0F7
Human Protein AtlasENSG00000113966
Peptide AtlasQ9H0F7
HPRD10588
IPIIPI00021685   IPI00974545   IPI00789499   IPI00946662   
Protein Interaction databases
DIP (DOE-UCLA)Q9H0F7
IntAct (EBI)Q9H0F7
FunCoupENSG00000113966
BioGRIDARL6
STRING (EMBL)ARL6
ZODIACARL6
Ontologies - Pathways
QuickGOQ9H0F7
Ontology : AmiGOprotein binding  GTP binding  phospholipid binding  cytoplasm  cytosol  axonemal microtubule  plasma membrane  cilium  cilium  cilium  axoneme  protein targeting to membrane  small GTPase mediated signal transduction  determination of left/right symmetry  brain development  visual perception  regulation of smoothened signaling pathway  retina layer formation  membrane  Wnt signaling pathway  membrane coat  melanosome transport  BBSome  fat cell differentiation  metal ion binding  protein polymerization  cilium assembly  cilium assembly  protein localization to cilium  extracellular exosome  protein localization to non-motile cilium  protein transport from ciliary membrane to plasma membrane  
Ontology : EGO-EBIprotein binding  GTP binding  phospholipid binding  cytoplasm  cytosol  axonemal microtubule  plasma membrane  cilium  cilium  cilium  axoneme  protein targeting to membrane  small GTPase mediated signal transduction  determination of left/right symmetry  brain development  visual perception  regulation of smoothened signaling pathway  retina layer formation  membrane  Wnt signaling pathway  membrane coat  melanosome transport  BBSome  fat cell differentiation  metal ion binding  protein polymerization  cilium assembly  cilium assembly  protein localization to cilium  extracellular exosome  protein localization to non-motile cilium  protein transport from ciliary membrane to plasma membrane  
NDEx NetworkARL6
Atlas of Cancer Signalling NetworkARL6
Wikipedia pathwaysARL6
Orthology - Evolution
OrthoDB84100
GeneTree (enSembl)ENSG00000113966
Phylogenetic Trees/Animal Genes : TreeFamARL6
HOVERGENQ9H0F7
HOGENOMQ9H0F7
Homologs : HomoloGeneARL6
Homology/Alignments : Family Browser (UCSC)ARL6
Gene fusions - Rearrangements
Fusion: TCGAAC110491.1 ARL6 3q11.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARL6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARL6
dbVarARL6
ClinVarARL6
1000_GenomesARL6 
Exome Variant ServerARL6
ExAC (Exome Aggregation Consortium)ARL6 (select the gene name)
Genetic variants : HAPMAP84100
Genomic Variants (DGV)ARL6 [DGVbeta]
DECIPHERARL6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARL6 
Mutations
ICGC Data PortalARL6 
TCGA Data PortalARL6 
Broad Tumor PortalARL6
OASIS PortalARL6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARL6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARL6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
LOVD (Leiden Open Variation Database)EURO-WABB PROJECT OPEN VARIATION DATABASE
BioMutasearch ARL6
DgiDB (Drug Gene Interaction Database)ARL6
DoCM (Curated mutations)ARL6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARL6 (select a term)
intoGenARL6
Cancer3DARL6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM209900    268000    600151    608845    613575   
Orphanet659    3244   
MedgenARL6
Genetic Testing Registry ARL6
NextProtQ9H0F7 [Medical]
TSGene84100
GENETestsARL6
Target ValidationARL6
Huge Navigator ARL6 [HugePedia]
snp3D : Map Gene to Disease84100
BioCentury BCIQARL6
ClinGenARL6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84100
Chemical/Pharm GKB GenePA134931939
Clinical trialARL6
Miscellaneous
canSAR (ICR)ARL6 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARL6
EVEXARL6
GoPubMedARL6
iHOPARL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:55:27 CEST 2017

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