Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ARL8A (ADP ribosylation factor like GTPase 8A)

Identity

Alias (NCBI)ARL10B
GIE2
HGNC (Hugo) ARL8A
HGNC Alias symbFLJ45195
Gie2
HGNC Previous nameARL10B
HGNC Previous nameADP-ribosylation factor-like 10B
 ADP-ribosylation factor-like 8A
LocusID (NCBI) 127829
Atlas_Id 60504
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 202133404 and ends at 202144743 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARL8A (1q32.1) / ARL8A (1q32.1)MIDN (19p13.3) / ARL8A (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ARL8A   25192
Cards
Entrez_Gene (NCBI)ARL8A    ADP ribosylation factor like GTPase 8A
AliasesARL10B; GIE2
GeneCards (Weizmann)ARL8A
Ensembl hg19 (Hinxton)ENSG00000143862 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143862 [Gene_View]  ENSG00000143862 [Sequence]  chr1:202133404-202144743 [Contig_View]  ARL8A [Vega]
ICGC DataPortalENSG00000143862
TCGA cBioPortalARL8A
AceView (NCBI)ARL8A
Genatlas (Paris)ARL8A
SOURCE (Princeton)ARL8A
Genetics Home Reference (NIH)ARL8A
Genomic and cartography
GoldenPath hg38 (UCSC)ARL8A  -     chr1:202133404-202144743 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARL8A  -     1q32.1   [Description]    (hg19-Feb_2009)
GoldenPathARL8A - 1q32.1 [CytoView hg19]  ARL8A - 1q32.1 [CytoView hg38]
ImmunoBaseENSG00000143862
genome Data Viewer NCBIARL8A [Mapview hg19]  
OMIM616597   
Gene and transcription
Genbank (Entrez)AB118752 AK127138 AK313122 AW090198 BC015408
RefSeq transcript (Entrez)NM_001256129 NM_138795
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARL8A
Alternative Splicing GalleryENSG00000143862
Gene ExpressionARL8A [ NCBI-GEO ]   ARL8A [ EBI - ARRAY_EXPRESS ]   ARL8A [ SEEK ]   ARL8A [ MEM ]
Gene Expression Viewer (FireBrowse)ARL8A [ Firebrowse - Broad ]
GenevisibleExpression of ARL8A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)127829
GTEX Portal (Tissue expression)ARL8A
Human Protein AtlasENSG00000143862-ARL8A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BM9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BM9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BM9
Splice isoforms : SwissVarQ96BM9
PhosPhoSitePlusQ96BM9
Domaine pattern : Prosite (Expaxy)ARF (PS51417)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase_ARF/SAR   
Domain families : Pfam (Sanger)Arf (PF00025)   
Domain families : Pfam (NCBI)pfam00025   
Conserved Domain (NCBI)ARL8A
Blocks (Seattle)ARL8A
PDB (RSDB)1ZD9    2H18    4ILE   
PDB Europe1ZD9    2H18    4ILE   
PDB (PDBSum)1ZD9    2H18    4ILE   
PDB (IMB)1ZD9    2H18    4ILE   
Structural Biology KnowledgeBase1ZD9    2H18    4ILE   
SCOP (Structural Classification of Proteins)1ZD9    2H18    4ILE   
CATH (Classification of proteins structures)1ZD9    2H18    4ILE   
SuperfamilyQ96BM9
Human Protein Atlas [tissue]ENSG00000143862-ARL8A [tissue]
Peptide AtlasQ96BM9
HPRD09807
IPIIPI00060031   
Protein Interaction databases
DIP (DOE-UCLA)Q96BM9
IntAct (EBI)Q96BM9
BioGRIDARL8A
STRING (EMBL)ARL8A
ZODIACARL8A
Ontologies - Pathways
QuickGOQ96BM9
Ontology : AmiGOGTPase activity  protein binding  GTP binding  cytoplasm  lysosomal membrane  lysosomal membrane  vacuolar membrane  plasma membrane  cell cycle  chromosome segregation  anterograde axonal transport  protein transport  membrane  cell junction  midbody  late endosome membrane  azurophil granule membrane  alpha-tubulin binding  neutrophil degranulation  synapse  beta-tubulin binding  spindle midzone  cell division  extracellular exosome  ficolin-1-rich granule membrane  axon cytoplasm  
Ontology : EGO-EBIGTPase activity  protein binding  GTP binding  cytoplasm  lysosomal membrane  lysosomal membrane  vacuolar membrane  plasma membrane  cell cycle  chromosome segregation  anterograde axonal transport  protein transport  membrane  cell junction  midbody  late endosome membrane  azurophil granule membrane  alpha-tubulin binding  neutrophil degranulation  synapse  beta-tubulin binding  spindle midzone  cell division  extracellular exosome  ficolin-1-rich granule membrane  axon cytoplasm  
NDEx NetworkARL8A
Atlas of Cancer Signalling NetworkARL8A
Wikipedia pathwaysARL8A
Orthology - Evolution
OrthoDB127829
GeneTree (enSembl)ENSG00000143862
Phylogenetic Trees/Animal Genes : TreeFamARL8A
HOGENOMQ96BM9
Homologs : HomoloGeneARL8A
Homology/Alignments : Family Browser (UCSC)ARL8A
Gene fusions - Rearrangements
Fusion : QuiverARL8A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARL8A [hg38]
dbVarARL8A
ClinVarARL8A
MonarchARL8A
1000_GenomesARL8A 
Exome Variant ServerARL8A
GNOMAD BrowserENSG00000143862
Varsome BrowserARL8A
Genomic Variants (DGV)ARL8A [DGVbeta]
DECIPHERARL8A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARL8A 
Mutations
ICGC Data PortalARL8A 
TCGA Data PortalARL8A 
Broad Tumor PortalARL8A
OASIS PortalARL8A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARL8A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARL8A
Mutations and Diseases : HGMDARL8A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARL8A
DgiDB (Drug Gene Interaction Database)ARL8A
DoCM (Curated mutations)ARL8A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARL8A (select a term)
intoGenARL8A
Cancer3DARL8A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616597   
Orphanet
DisGeNETARL8A
MedgenARL8A
Genetic Testing Registry ARL8A
NextProtQ96BM9 [Medical]
GENETestsARL8A
Target ValidationARL8A
Huge Navigator ARL8A [HugePedia]
ClinGenARL8A
Clinical trials, drugs, therapy
MyCancerGenomeARL8A
Protein Interactions : CTD
Pharm GKB GenePA134905021
Clinical trialARL8A
Miscellaneous
canSAR (ICR)ARL8A (select the gene name)
HarmonizomeARL8A
DataMed IndexARL8A
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARL8A
EVEXARL8A
GoPubMedARL8A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 16:46:16 CET 2020
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