ARL8B (ADP ribosylation factor like GTPase 8B)

2018-02-01  

Identity

HGNC
ARL8B
LOCATION
3p26.1
LOCUSID
55207
ALIAS
ARL10C,Gie1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55207
MIM: 616596
HGNC: 25564
Ensembl: ENSG00000134108

Variants:

dbSNP: 55207
ClinVar: 55207
TCGA: ENSG00000134108
COSMIC: ARL8B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134108ENST00000256496Q9NVJ2
ENSG00000134108ENST00000256496A0A024R2D4
ENSG00000134108ENST00000419534Q9NVJ2
ENSG00000134108ENST00000429403F8WAW5
ENSG00000134108ENST00000455168F2Z344
ENSG00000134108ENST00000611208Q9NVJ2
ENSG00000134108ENST00000611208A0A024R2D4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
218023202011Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.51
193985762009Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.46
259088472015The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes.33
166503812006The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes.29
240885712013Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.24
218242482011Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.22
289934672017LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.19
153316352004Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation.14
271055402016The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo.11
278084812016RNF167 targets Arl8B for degradation to regulate lysosome positioning and endocytic trafficking.3

Citation

Dessen P

ARL8B (ADP ribosylation factor like GTPase 8B)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57373/arl8b