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ARNT2 (aryl hydrocarbon receptor nuclear translocator 2)

Identity

Alias_symbol (synonym)KIAA0307
bHLHe1
Other aliasWEDAS
HGNC (Hugo) ARNT2
LocusID (NCBI) 9915
Atlas_Id 50423
Location 15q25.1  [Link to chromosome band 15q25]
Location_base_pair Starts at 80404350 and ends at 80597936 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARNT2 (15q25.1) / ARNT2 (15q25.1)ARNT2 (15q25.1) / MS4A3 (11q12.1)ARNT2 (15q25.1) / NDST1 (5q33.1)
ARNT2 (15q25.1) / PDLIM5 (4q22.3)ARNT2 (15q25.1) / TNFAIP8L3 (15q21.2)ARNT2 (15q25.1) / ZFAND3 (6p21.2)
CXCL8 (4q13.3) / ARNT2 (15q25.1)RORA (15q22.2) / ARNT2 (15q25.1)SRCIN1 (17q12) / ARNT2 (15q25.1)
ARNT2 15q25.1 / MS4A3 11q12.1ARNT2 15q25.1 / NDST1 5q33.1ARNT2 15q25.1 / PDLIM5 4q22.3
ARNT2 15q25.1 / TNFAIP8L3 15q21.2ARNT2 15q25.1 / ZFAND3 6p21.2RORA 15q22.2 / ARNT2 15q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARNT2   16876
Cards
Entrez_Gene (NCBI)ARNT2  9915  aryl hydrocarbon receptor nuclear translocator 2
AliasesWEDAS; bHLHe1
GeneCards (Weizmann)ARNT2
Ensembl hg19 (Hinxton)ENSG00000172379 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172379 [Gene_View]  chr15:80404350-80597936 [Contig_View]  ARNT2 [Vega]
ICGC DataPortalENSG00000172379
TCGA cBioPortalARNT2
AceView (NCBI)ARNT2
Genatlas (Paris)ARNT2
WikiGenes9915
SOURCE (Princeton)ARNT2
Genetics Home Reference (NIH)ARNT2
Genomic and cartography
GoldenPath hg38 (UCSC)ARNT2  -     chr15:80404350-80597936 +  15q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARNT2  -     15q25.1   [Description]    (hg19-Feb_2009)
EnsemblARNT2 - 15q25.1 [CytoView hg19]  ARNT2 - 15q25.1 [CytoView hg38]
Mapping of homologs : NCBIARNT2 [Mapview hg19]  ARNT2 [Mapview hg38]
OMIM606036   615926   
Gene and transcription
Genbank (Entrez)AB002305 AK295763 AM392973 BC029293 BC036099
RefSeq transcript (Entrez)NM_014862
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARNT2
Cluster EST : UnigeneHs.459070 [ NCBI ]
CGAP (NCI)Hs.459070
Alternative Splicing GalleryENSG00000172379
Gene ExpressionARNT2 [ NCBI-GEO ]   ARNT2 [ EBI - ARRAY_EXPRESS ]   ARNT2 [ SEEK ]   ARNT2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARNT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9915
GTEX Portal (Tissue expression)ARNT2
Human Protein AtlasENSG00000172379-ARNT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBZ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBZ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBZ2
Splice isoforms : SwissVarQ9HBZ2
PhosPhoSitePlusQ9HBZ2
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)bHLH_dom    Nuc_translocat    PAC    PAS    PAS_fold    PAS_fold_3   
Domain families : Pfam (Sanger)HLH (PF00010)    PAS (PF00989)    PAS_3 (PF08447)   
Domain families : Pfam (NCBI)pfam00010    pfam00989    pfam08447   
Domain families : Smart (EMBL)HLH (SM00353)  PAC (SM00086)  PAS (SM00091)  
Conserved Domain (NCBI)ARNT2
DMDM Disease mutations9915
Blocks (Seattle)ARNT2
SuperfamilyQ9HBZ2
Human Protein Atlas [tissue]ENSG00000172379-ARNT2 [tissue]
Peptide AtlasQ9HBZ2
IPIIPI00796054   IPI01015076   IPI00478506   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBZ2
IntAct (EBI)Q9HBZ2
FunCoupENSG00000172379
BioGRIDARNT2
STRING (EMBL)ARNT2
ZODIACARNT2
Ontologies - Pathways
QuickGOQ9HBZ2
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  response to hypoxia  in utero embryonic development  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription factor complex  cytoplasm  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  xenobiotic metabolic process  central nervous system development  brain development  positive regulation of cell proliferation  aryl hydrocarbon receptor binding  response to estradiol  negative regulation of apoptotic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  protein heterodimerization activity  protein heterodimerization activity  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  response to hypoxia  in utero embryonic development  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription factor complex  cytoplasm  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  xenobiotic metabolic process  central nervous system development  brain development  positive regulation of cell proliferation  aryl hydrocarbon receptor binding  response to estradiol  negative regulation of apoptotic process  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  protein heterodimerization activity  protein heterodimerization activity  
Pathways : KEGGPathways in cancer    Transcriptional misregulation in cancer    Renal cell carcinoma   
NDEx NetworkARNT2
Atlas of Cancer Signalling NetworkARNT2
Wikipedia pathwaysARNT2
Orthology - Evolution
OrthoDB9915
GeneTree (enSembl)ENSG00000172379
Phylogenetic Trees/Animal Genes : TreeFamARNT2
HOVERGENQ9HBZ2
HOGENOMQ9HBZ2
Homologs : HomoloGeneARNT2
Homology/Alignments : Family Browser (UCSC)ARNT2
Gene fusions - Rearrangements
Fusion : MitelmanARNT2/MS4A3 [15q25.1/11q12.1]  
Fusion : MitelmanARNT2/NDST1 [15q25.1/5q33.1]  [t(5;15)(q33;q25)]  
Fusion : MitelmanARNT2/PDLIM5 [15q25.1/4q22.3]  [t(4;15)(q22;q25)]  
Fusion : MitelmanARNT2/TNFAIP8L3 [15q25.1/15q21.2]  [t(15;15)(q21;q25)]  
Fusion : MitelmanARNT2/ZFAND3 [15q25.1/6p21.2]  [t(6;15)(p21;q25)]  
Fusion : MitelmanRORA/ARNT2 [15q22.2/15q25.1]  [t(15;15)(q22;q25)]  
Fusion: TCGAARNT2 15q25.1 MS4A3 11q12.1 KIRC
Fusion: TCGAARNT2 15q25.1 NDST1 5q33.1 PRAD
Fusion: TCGAARNT2 15q25.1 PDLIM5 4q22.3 BRCA
Fusion: TCGAARNT2 15q25.1 TNFAIP8L3 15q21.2 KIRC
Fusion: TCGAARNT2 15q25.1 ZFAND3 6p21.2 PRAD
Fusion: TCGARORA 15q22.2 ARNT2 15q25.1 BRCA
Fusion: Tumor Portal ARNT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARNT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARNT2
dbVarARNT2
ClinVarARNT2
1000_GenomesARNT2 
Exome Variant ServerARNT2
ExAC (Exome Aggregation Consortium)ENSG00000172379
GNOMAD BrowserENSG00000172379
Genetic variants : HAPMAP9915
Genomic Variants (DGV)ARNT2 [DGVbeta]
DECIPHERARNT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARNT2 
Mutations
ICGC Data PortalARNT2 
TCGA Data PortalARNT2 
Broad Tumor PortalARNT2
OASIS PortalARNT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARNT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARNT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARNT2
DgiDB (Drug Gene Interaction Database)ARNT2
DoCM (Curated mutations)ARNT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARNT2 (select a term)
intoGenARNT2
Cancer3DARNT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606036    615926   
Orphanet2825   
MedgenARNT2
Genetic Testing Registry ARNT2
NextProtQ9HBZ2 [Medical]
TSGene9915
GENETestsARNT2
Target ValidationARNT2
Huge Navigator ARNT2 [HugePedia]
snp3D : Map Gene to Disease9915
BioCentury BCIQARNT2
ClinGenARNT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9915
Chemical/Pharm GKB GenePA24995
Clinical trialARNT2
Miscellaneous
canSAR (ICR)ARNT2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARNT2
EVEXARNT2
GoPubMedARNT2
iHOPARNT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:41:00 CET 2017

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