| Nomenclature |
|---|
| HGNC (Hugo) | ARNTL 701 |
| Cards |
|---|
| Entrez_Gene (NCBI) | ARNTL 406 aryl hydrocarbon receptor nuclear translocator like |
| Aliases | BMAL1; BMAL1c; JAP3; MOP3; |
| PASD3; TIC; bHLHe5 |
| GeneCards (Weizmann) | ARNTL |
| Ensembl hg19 (Hinxton) | ENSG00000133794 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000133794 [Gene_View] ENSG00000133794 [Sequence] chr11:13277727-13387265 [Contig_View] ARNTL [Vega] |
| ICGC DataPortal | ENSG00000133794 |
| TCGA cBioPortal | ARNTL |
| AceView (NCBI) | ARNTL |
| Genatlas (Paris) | ARNTL |
| WikiGenes | 406 |
| SOURCE (Princeton) | ARNTL |
| Genetics Home Reference (NIH) | ARNTL |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | ARNTL - chr11:13277727-13387265 + 11p15.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | ARNTL - 11p15.3 [Description] (hg19-Feb_2009) |
| Ensembl | ARNTL - 11p15.3 [CytoView hg19] ARNTL - 11p15.3 [CytoView hg38] |
| Mapping of homologs : NCBI | ARNTL [Mapview hg19] ARNTL [Mapview hg38] |
| OMIM | 602550 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB000812 AB000814 AB000815 AB000816 AF044288 |
| RefSeq transcript (Entrez) | NM_001030272 NM_001030273 NM_001178 NM_001297719 NM_001297722 NM_001297724 NM_001351804 NM_001351805 NM_001351806 NM_001351807 NM_001351808 NM_001351809 NM_001351810 NM_001351811 NM_001351812 NM_001351813 NM_001351814 NM_001351815 NM_001351816 NM_001351817 NM_001351818 NM_001351819 NM_001351820 NM_001351821 NM_001351822 NM_001351823 NM_001351824 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | ARNTL |
| Cluster EST : Unigene | Hs.65734 [ NCBI ] |
| CGAP (NCI) | Hs.65734 |
| Alternative Splicing Gallery | ENSG00000133794 |
| Gene Expression | ARNTL [ NCBI-GEO ] ARNTL [ EBI - ARRAY_EXPRESS ]
ARNTL [ SEEK ] ARNTL [ MEM ] |
| Gene Expression Viewer (FireBrowse) | ARNTL [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 406 |
| GTEX Portal (Tissue expression) | ARNTL |
| Human Protein Atlas | ENSG00000133794-ARNTL [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O00327 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O00327 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O00327 |
| Splice isoforms : SwissVar | O00327 |
| PhosPhoSitePlus | O00327 |
| Domaine pattern : Prosite (Expaxy) | BHLH (PS50888) PAS (PS50112) |
| Domains : Interpro (EBI) | bHLH_dom HLH_DNA-bd_sf Nuc_translocat PAC PAS PAS-like_dom_sf PAS_fold |
| Domain families : Pfam (Sanger) | HLH (PF00010) PAS (PF00989) |
| Domain families : Pfam (NCBI) | pfam00010 pfam00989 |
| Domain families : Smart (EMBL) | HLH (SM00353) PAC (SM00086) PAS (SM00091) |
| Conserved Domain (NCBI) | ARNTL |
| DMDM Disease mutations | 406 |
| Blocks (Seattle) | ARNTL |
| PDB (SRS) | 4H10 |
| PDB (PDBSum) | 4H10 |
| PDB (IMB) | 4H10 |
| PDB (RSDB) | 4H10 |
| Structural Biology KnowledgeBase | 4H10 |
| SCOP (Structural Classification of Proteins) | 4H10 |
| CATH (Classification of proteins structures) | 4H10 |
| Superfamily | O00327 |
| Human Protein Atlas [tissue] | ENSG00000133794-ARNTL [tissue] |
| Peptide Atlas | O00327 |
| HPRD | 03973 |
| IPI | IPI00412162 IPI00217732 IPI00783543 IPI00413132 IPI00217734 IPI00217735 IPI00217736 IPI00910251 IPI00879656 IPI00982968 IPI00976900 IPI01025988 IPI00978435 IPI00977551 IPI00979645 IPI00981131 IPI00980333 IPI00978797 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O00327 |
| IntAct (EBI) | O00327 |
| FunCoup | ENSG00000133794 |
| BioGRID | ARNTL |
| STRING (EMBL) | ARNTL |
| ZODIAC | ARNTL |
| Ontologies - Pathways |
|---|
| QuickGO | O00327 |
| Ontology : AmiGO | protein import into nucleus, translocation transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA binding protein binding nucleus nucleoplasm nucleoplasm transcription factor complex regulation of transcription, DNA-templated spermatogenesis circadian rhythm PML body aryl hydrocarbon receptor binding negative regulation of TOR signaling circadian regulation of gene expression circadian regulation of gene expression chromatoid body regulation of protein catabolic process regulation of hair cycle positive regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle bHLH transcription factor binding sequence-specific DNA binding negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein heterodimerization activity regulation of neurogenesis regulation of insulin secretion regulation of cell cycle response to redox state Hsp90 protein binding maternal process involved in parturition repressing transcription factor binding E-box binding positive regulation of canonical Wnt signaling pathway oxidative stress-induced premature senescence negative regulation of cold-induced thermogenesis positive regulation of protein acetylation regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway regulation of cellular senescence positive regulation of skeletal muscle cell differentiation |
| Ontology : EGO-EBI | protein import into nucleus, translocation transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA binding protein binding nucleus nucleoplasm nucleoplasm transcription factor complex regulation of transcription, DNA-templated spermatogenesis circadian rhythm PML body aryl hydrocarbon receptor binding negative regulation of TOR signaling circadian regulation of gene expression circadian regulation of gene expression chromatoid body regulation of protein catabolic process regulation of hair cycle positive regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle bHLH transcription factor binding sequence-specific DNA binding negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein heterodimerization activity regulation of neurogenesis regulation of insulin secretion regulation of cell cycle response to redox state Hsp90 protein binding maternal process involved in parturition repressing transcription factor binding E-box binding positive regulation of canonical Wnt signaling pathway oxidative stress-induced premature senescence negative regulation of cold-induced thermogenesis positive regulation of protein acetylation regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway regulation of cellular senescence positive regulation of skeletal muscle cell differentiation |
| Pathways : KEGG | Circadian rhythm Dopaminergic synapse Herpes simplex infection |
| NDEx Network | ARNTL |
| Atlas of Cancer Signalling Network | ARNTL |
| Wikipedia pathways | ARNTL |
| Orthology - Evolution |
|---|
| OrthoDB | 406 |
| GeneTree (enSembl) | ENSG00000133794 |
| Phylogenetic Trees/Animal Genes : TreeFam | ARNTL |
| HOVERGEN | O00327 |
| HOGENOM | O00327 |
| Homologs : HomoloGene | ARNTL |
| Homology/Alignments : Family Browser (UCSC) | ARNTL |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | ARNTL/TEAD1 [11p15.2/11p15.3] |
| Fusion Portal | ARNTL 11p15.2 TEAD1 11p15.3 BRCA HNSC |
| Fusion Cancer (Beijing) | ARNTL [11p15.2] - FN1 [2q35] [FUSC003415] |
| Fusion : Quiver | ARNTL |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | ARNTL [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | ARNTL |
| dbVar | ARNTL |
| ClinVar | ARNTL |
| 1000_Genomes | ARNTL |
| Exome Variant Server | ARNTL |
| ExAC (Exome Aggregation Consortium) | ENSG00000133794 |
| GNOMAD Browser | ENSG00000133794 |
| Varsome Browser | ARNTL |
| Genetic variants : HAPMAP | 406 |
| Genomic Variants (DGV) | ARNTL [DGVbeta] |
| DECIPHER | ARNTL [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | ARNTL |
| Mutations |
|---|
| ICGC Data Portal | ARNTL |
| TCGA Data Portal | ARNTL |
| Broad Tumor Portal | ARNTL |
| OASIS Portal | ARNTL [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | ARNTL [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | ARNTL |
| intOGen Portal | ARNTL |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search ARNTL |
| DgiDB (Drug Gene Interaction Database) | ARNTL |
| DoCM (Curated mutations) | ARNTL (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | ARNTL (select a term) |
| intoGen | ARNTL |
| Cancer3D | ARNTL(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602550 |
| Orphanet | |
| DisGeNET | ARNTL |
| Medgen | ARNTL |
| Genetic Testing Registry | ARNTL
|
| NextProt | O00327 [Medical] |
| TSGene | 406 |
| GENETests | ARNTL |
| Target Validation | ARNTL |
| Huge Navigator |
ARNTL [HugePedia] |
| snp3D : Map Gene to Disease | 406 |
| BioCentury BCIQ | ARNTL |
| ClinGen | ARNTL |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 406 |
| Chemical/Pharm GKB Gene | PA24996 |
| Clinical trial | ARNTL |
| Miscellaneous |
|---|
| canSAR (ICR) | ARNTL (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 149 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | ARNTL |
| EVEX | ARNTL |
| GoPubMed | ARNTL |
| iHOP | ARNTL |
