Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ARNTL (aryl hydrocarbon receptor nuclear translocator like)

Identity

Alias_symbol (synonym)MOP3
JAP3
BMAL1
PASD3
bHLHe5
Other aliasBMAL1c
TIC
HGNC (Hugo) ARNTL
LocusID (NCBI) 406
Atlas_Id 51125
Location 11p15.3  [Link to chromosome band 11p15]
Location_base_pair Starts at 13277727 and ends at 13387265 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARNTL (11p15.2) / ARNTL (11p15.2)ARNTL (11p15.2) / FN1 (2q35)ARNTL (11p15.2) / TEAD1 (11p15.3)
PHYKPL (5q35.3) / ARNTL (11p15.2)ARNTL 11p15.2 / TEAD1 11p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARNTL   701
Cards
Entrez_Gene (NCBI)ARNTL  406  aryl hydrocarbon receptor nuclear translocator like
AliasesBMAL1; BMAL1c; JAP3; MOP3; 
PASD3; TIC; bHLHe5
GeneCards (Weizmann)ARNTL
Ensembl hg19 (Hinxton)ENSG00000133794 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133794 [Gene_View]  chr11:13277727-13387265 [Contig_View]  ARNTL [Vega]
ICGC DataPortalENSG00000133794
TCGA cBioPortalARNTL
AceView (NCBI)ARNTL
Genatlas (Paris)ARNTL
WikiGenes406
SOURCE (Princeton)ARNTL
Genetics Home Reference (NIH)ARNTL
Genomic and cartography
GoldenPath hg38 (UCSC)ARNTL  -     chr11:13277727-13387265 +  11p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARNTL  -     11p15.3   [Description]    (hg19-Feb_2009)
EnsemblARNTL - 11p15.3 [CytoView hg19]  ARNTL - 11p15.3 [CytoView hg38]
Mapping of homologs : NCBIARNTL [Mapview hg19]  ARNTL [Mapview hg38]
OMIM602550   
Gene and transcription
Genbank (Entrez)AB000812 AB000814 AB000815 AB000816 AF044288
RefSeq transcript (Entrez)NM_001030272 NM_001030273 NM_001178 NM_001297719 NM_001297722 NM_001297724
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARNTL
Cluster EST : UnigeneHs.65734 [ NCBI ]
CGAP (NCI)Hs.65734
Alternative Splicing GalleryENSG00000133794
Gene ExpressionARNTL [ NCBI-GEO ]   ARNTL [ EBI - ARRAY_EXPRESS ]   ARNTL [ SEEK ]   ARNTL [ MEM ]
Gene Expression Viewer (FireBrowse)ARNTL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)406
GTEX Portal (Tissue expression)ARNTL
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00327   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00327  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00327
Splice isoforms : SwissVarO00327
PhosPhoSitePlusO00327
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)bHLH_dom    Nuc_translocat    PAC    PAS    PAS_fold   
Domain families : Pfam (Sanger)HLH (PF00010)    PAS (PF00989)   
Domain families : Pfam (NCBI)pfam00010    pfam00989   
Domain families : Smart (EMBL)HLH (SM00353)  PAC (SM00086)  PAS (SM00091)  
Conserved Domain (NCBI)ARNTL
DMDM Disease mutations406
Blocks (Seattle)ARNTL
PDB (SRS)4H10   
PDB (PDBSum)4H10   
PDB (IMB)4H10   
PDB (RSDB)4H10   
Structural Biology KnowledgeBase4H10   
SCOP (Structural Classification of Proteins)4H10   
CATH (Classification of proteins structures)4H10   
SuperfamilyO00327
Human Protein AtlasENSG00000133794
Peptide AtlasO00327
HPRD03973
IPIIPI00412162   IPI00217732   IPI00783543   IPI00413132   IPI00217734   IPI00217735   IPI00217736   IPI00910251   IPI00879656   IPI00982968   IPI00976900   IPI01025988   IPI00978435   IPI00977551   IPI00979645   IPI00981131   IPI00980333   IPI00978797   
Protein Interaction databases
DIP (DOE-UCLA)O00327
IntAct (EBI)O00327
FunCoupENSG00000133794
BioGRIDARNTL
STRING (EMBL)ARNTL
ZODIACARNTL
Ontologies - Pathways
QuickGOO00327
Ontology : AmiGOprotein import into nucleus, translocation  transcription regulatory region sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  core promoter sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II transcription factor binding  DNA binding  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  spermatogenesis  circadian rhythm  PML body  aryl hydrocarbon receptor binding  negative regulation of TOR signaling  circadian regulation of gene expression  circadian regulation of gene expression  chromatoid body  regulation of protein catabolic process  regulation of hair cycle  positive regulation of circadian rhythm  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  bHLH transcription factor binding  sequence-specific DNA binding  negative regulation of fat cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  regulation of neurogenesis  regulation of insulin secretion  regulation of cell cycle  response to redox state  Hsp90 protein binding  maternal process involved in parturition  repressing transcription factor binding  E-box binding  positive regulation of canonical Wnt signaling pathway  oxidative stress-induced premature senescence  regulation of type B pancreatic cell development  negative regulation of glucocorticoid receptor signaling pathway  regulation of cellular senescence  positive regulation of skeletal muscle cell differentiation  
Ontology : EGO-EBIprotein import into nucleus, translocation  transcription regulatory region sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  core promoter sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II transcription factor binding  DNA binding  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  spermatogenesis  circadian rhythm  PML body  aryl hydrocarbon receptor binding  negative regulation of TOR signaling  circadian regulation of gene expression  circadian regulation of gene expression  chromatoid body  regulation of protein catabolic process  regulation of hair cycle  positive regulation of circadian rhythm  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  bHLH transcription factor binding  sequence-specific DNA binding  negative regulation of fat cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  regulation of neurogenesis  regulation of insulin secretion  regulation of cell cycle  response to redox state  Hsp90 protein binding  maternal process involved in parturition  repressing transcription factor binding  E-box binding  positive regulation of canonical Wnt signaling pathway  oxidative stress-induced premature senescence  regulation of type B pancreatic cell development  negative regulation of glucocorticoid receptor signaling pathway  regulation of cellular senescence  positive regulation of skeletal muscle cell differentiation  
Pathways : BIOCARTACircadian Rhythms [Genes]   
Pathways : KEGGCircadian rhythm    Dopaminergic synapse    Herpes simplex infection   
NDEx NetworkARNTL
Atlas of Cancer Signalling NetworkARNTL
Wikipedia pathwaysARNTL
Orthology - Evolution
OrthoDB406
GeneTree (enSembl)ENSG00000133794
Phylogenetic Trees/Animal Genes : TreeFamARNTL
HOVERGENO00327
HOGENOMO00327
Homologs : HomoloGeneARNTL
Homology/Alignments : Family Browser (UCSC)ARNTL
Gene fusions - Rearrangements
Fusion : MitelmanARNTL/TEAD1 [11p15.2/11p15.3]  
Fusion: TCGAARNTL 11p15.2 TEAD1 11p15.3 BRCA HNSC
Fusion Cancer (Beijing)ARNTL [11p15.2]  -  FN1 [2q35]  [FUSC003415]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARNTL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARNTL
dbVarARNTL
ClinVarARNTL
1000_GenomesARNTL 
Exome Variant ServerARNTL
ExAC (Exome Aggregation Consortium)ARNTL (select the gene name)
Genetic variants : HAPMAP406
Genomic Variants (DGV)ARNTL [DGVbeta]
DECIPHERARNTL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARNTL 
Mutations
ICGC Data PortalARNTL 
TCGA Data PortalARNTL 
Broad Tumor PortalARNTL
OASIS PortalARNTL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARNTL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARNTL
intOGen PortalARNTL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARNTL
DgiDB (Drug Gene Interaction Database)ARNTL
DoCM (Curated mutations)ARNTL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARNTL (select a term)
intoGenARNTL
Cancer3DARNTL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602550   
Orphanet
MedgenARNTL
Genetic Testing Registry ARNTL
NextProtO00327 [Medical]
TSGene406
GENETestsARNTL
Target ValidationARNTL
Huge Navigator ARNTL [HugePedia]
snp3D : Map Gene to Disease406
BioCentury BCIQARNTL
ClinGenARNTL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD406
Chemical/Pharm GKB GenePA24996
Clinical trialARNTL
Miscellaneous
canSAR (ICR)ARNTL (select the gene name)
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARNTL
EVEXARNTL
GoPubMedARNTL
iHOPARNTL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 18:58:08 CEST 2017

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