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ARNTL2 (aryl hydrocarbon receptor nuclear translocator like 2)

Identity

Alias_symbol (synonym)BMAL2
MOP9
CLIF
PASD9
bHLHe6
Other alias
HGNC (Hugo) ARNTL2
LocusID (NCBI) 56938
Atlas_Id 52688
Location 12p11.23  [Link to chromosome band 12p11]
Location_base_pair Starts at 27332854 and ends at 27425813 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARNTL2 (12p11.23) / ITPR2 (12p12.1)RNF115 (1q21.1) / ARNTL2 (12p11.23)STAT5A (17q21.2) / ARNTL2 (12p11.23)
ARNTL2 12p11.23 / ITPR2 12p12.1STAT5A 17q21.2 / ARNTL2 12p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARNTL2   18984
Cards
Entrez_Gene (NCBI)ARNTL2  56938  aryl hydrocarbon receptor nuclear translocator like 2
AliasesBMAL2; CLIF; MOP9; PASD9; 
bHLHe6
GeneCards (Weizmann)ARNTL2
Ensembl hg19 (Hinxton)ENSG00000029153 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000029153 [Gene_View]  chr12:27332854-27425813 [Contig_View]  ARNTL2 [Vega]
ICGC DataPortalENSG00000029153
TCGA cBioPortalARNTL2
AceView (NCBI)ARNTL2
Genatlas (Paris)ARNTL2
WikiGenes56938
SOURCE (Princeton)ARNTL2
Genetics Home Reference (NIH)ARNTL2
Genomic and cartography
GoldenPath hg38 (UCSC)ARNTL2  -     chr12:27332854-27425813 +  12p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARNTL2  -     12p11.23   [Description]    (hg19-Feb_2009)
EnsemblARNTL2 - 12p11.23 [CytoView hg19]  ARNTL2 - 12p11.23 [CytoView hg38]
Mapping of homologs : NCBIARNTL2 [Mapview hg19]  ARNTL2 [Mapview hg38]
OMIM614517   
Gene and transcription
Genbank (Entrez)AB039921 AF231338 AF231339 AF246960 AF246961
RefSeq transcript (Entrez)NM_001248002 NM_001248003 NM_001248004 NM_001248005 NM_020183
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARNTL2
Cluster EST : UnigeneHs.445447 [ NCBI ]
CGAP (NCI)Hs.445447
Alternative Splicing GalleryENSG00000029153
Gene ExpressionARNTL2 [ NCBI-GEO ]   ARNTL2 [ EBI - ARRAY_EXPRESS ]   ARNTL2 [ SEEK ]   ARNTL2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARNTL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56938
GTEX Portal (Tissue expression)ARNTL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WYA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WYA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WYA1
Splice isoforms : SwissVarQ8WYA1
PhosPhoSitePlusQ8WYA1
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)bHLH_dom    Nuc_translocat    PAS    PAS_fold   
Domain families : Pfam (Sanger)HLH (PF00010)    PAS (PF00989)   
Domain families : Pfam (NCBI)pfam00010    pfam00989   
Domain families : Smart (EMBL)HLH (SM00353)  PAS (SM00091)  
Conserved Domain (NCBI)ARNTL2
DMDM Disease mutations56938
Blocks (Seattle)ARNTL2
PDB (SRS)2KDK   
PDB (PDBSum)2KDK   
PDB (IMB)2KDK   
PDB (RSDB)2KDK   
Structural Biology KnowledgeBase2KDK   
SCOP (Structural Classification of Proteins)2KDK   
CATH (Classification of proteins structures)2KDK   
SuperfamilyQ8WYA1
Human Protein AtlasENSG00000029153
Peptide AtlasQ8WYA1
HPRD16507
IPIIPI00142781   IPI00163662   IPI00789255   IPI00795339   IPI00465306   IPI00788724   IPI00827866   IPI00827897   IPI00744129   IPI01009213   
Protein Interaction databases
DIP (DOE-UCLA)Q8WYA1
IntAct (EBI)Q8WYA1
FunCoupENSG00000029153
BioGRIDARNTL2
STRING (EMBL)ARNTL2
ZODIACARNTL2
Ontologies - Pathways
QuickGOQ8WYA1
Ontology : AmiGOtranscription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  transcription factor complex  nucleolus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  circadian rhythm  entrainment of circadian clock  positive regulation of circadian rhythm  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  E-box binding  
Ontology : EGO-EBItranscription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  transcription factor complex  nucleolus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  circadian rhythm  entrainment of circadian clock  positive regulation of circadian rhythm  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  E-box binding  
NDEx NetworkARNTL2
Atlas of Cancer Signalling NetworkARNTL2
Wikipedia pathwaysARNTL2
Orthology - Evolution
OrthoDB56938
GeneTree (enSembl)ENSG00000029153
Phylogenetic Trees/Animal Genes : TreeFamARNTL2
HOVERGENQ8WYA1
HOGENOMQ8WYA1
Homologs : HomoloGeneARNTL2
Homology/Alignments : Family Browser (UCSC)ARNTL2
Gene fusions - Rearrangements
Fusion : MitelmanARNTL2/ITPR2 [12p11.23/12p12.1]  
Fusion : MitelmanSTAT5A/ARNTL2 [17q21.2/12p11.23]  [t(12;17)(p11;q21)]  
Fusion: TCGAARNTL2 12p11.23 ITPR2 12p12.1 BRCA
Fusion: TCGASTAT5A 17q21.2 ARNTL2 12p11.23 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARNTL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARNTL2
dbVarARNTL2
ClinVarARNTL2
1000_GenomesARNTL2 
Exome Variant ServerARNTL2
ExAC (Exome Aggregation Consortium)ARNTL2 (select the gene name)
Genetic variants : HAPMAP56938
Genomic Variants (DGV)ARNTL2 [DGVbeta]
DECIPHERARNTL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARNTL2 
Mutations
ICGC Data PortalARNTL2 
TCGA Data PortalARNTL2 
Broad Tumor PortalARNTL2
OASIS PortalARNTL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARNTL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARNTL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARNTL2
DgiDB (Drug Gene Interaction Database)ARNTL2
DoCM (Curated mutations)ARNTL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARNTL2 (select a term)
intoGenARNTL2
Cancer3DARNTL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614517   
Orphanet
MedgenARNTL2
Genetic Testing Registry ARNTL2
NextProtQ8WYA1 [Medical]
TSGene56938
GENETestsARNTL2
Target ValidationARNTL2
Huge Navigator ARNTL2 [HugePedia]
snp3D : Map Gene to Disease56938
BioCentury BCIQARNTL2
ClinGenARNTL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56938
Chemical/Pharm GKB GenePA134896555
Clinical trialARNTL2
Miscellaneous
canSAR (ICR)ARNTL2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARNTL2
EVEXARNTL2
GoPubMedARNTL2
iHOPARNTL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 18:58:08 CEST 2017

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