ARNTL2 (aryl hydrocarbon receptor nuclear translocator like 2)

2012-04-01  

Identity

HGNC
LOCATION
12p11.23
LOCUSID
ALIAS
BMAL2,CLIF,MOP9,PASD9,bHLHe6
FUSION GENES

Other Information

Locus ID:

NCBI: 56938
MIM: 614517
HGNC: 18984
Ensembl: ENSG00000029153

Variants:

dbSNP: 56938
ClinVar: 56938
TCGA: ENSG00000029153
COSMIC: ARNTL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000029153ENST00000261178Q8WYA1
ENSG00000029153ENST00000266503Q8WYA1
ENSG00000029153ENST00000311001Q8WYA1
ENSG00000029153ENST00000395901Q8WYA1
ENSG00000029153ENST00000457040H0Y5R1
ENSG00000029153ENST00000542388Q8WYA1
ENSG00000029153ENST00000544915Q8WYA1
ENSG00000029153ENST00000546179Q8WYA1

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
182285282008Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.60
198399952009Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.49
205546942010Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.45
194701682009NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.42
221986372012ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer.39
203689932010ARNTL (BMAL1) and NPAS2 gene variants contribute to fertility and seasonality.32
196938012010PER2 variantion is associated with depression vulnerability.31
186632402008Genetic differences in human circadian clock genes among worldwide populations.30

Citation

Dessen P

ARNTL2 (aryl hydrocarbon receptor nuclear translocator like 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52688/arntl2