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ARPC1A (actin related protein 2/3 complex subunit 1A)

Identity

Alias_namesactin related protein 2/3 complex, subunit 1A (41 kD)
actin related protein 2/3 complex subunit 1A, 41kDa
Alias_symbol (synonym)SOP2Hs
SOP2L
Arc40
Other aliasHEL-68
HEL-S-307
HGNC (Hugo) ARPC1A
LocusID (NCBI) 10552
Atlas_Id 50815
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 98923496 and ends at 98963885 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARPC1A (7q22.1) / KIF1A (2q37.3)ARPC1A (7q22.1) / PRKAG1 (12q13.12)ARPC1A (7q22.1) / SMARCC1 (3p21.31)
ARPC1A (7q22.1) / TRRAP (7q22.1)ARPC1B (7q22.1) / ARPC1A (7q22.1)TMPO (12q23.1) / ARPC1A (7q22.1)
TOMM40L (1q23.3) / ARPC1A (7q22.1)ARPC1A 7q22.1 / TRRAP 7q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARPC1A   703
Cards
Entrez_Gene (NCBI)ARPC1A  10552  actin related protein 2/3 complex subunit 1A
AliasesArc40; HEL-68; HEL-S-307; SOP2Hs; 
SOP2L
GeneCards (Weizmann)ARPC1A
Ensembl hg19 (Hinxton)ENSG00000241685 [Gene_View]  chr7:98923496-98963885 [Contig_View]  ARPC1A [Vega]
Ensembl hg38 (Hinxton)ENSG00000241685 [Gene_View]  chr7:98923496-98963885 [Contig_View]  ARPC1A [Vega]
ICGC DataPortalENSG00000241685
TCGA cBioPortalARPC1A
AceView (NCBI)ARPC1A
Genatlas (Paris)ARPC1A
WikiGenes10552
SOURCE (Princeton)ARPC1A
Genetics Home Reference (NIH)ARPC1A
Genomic and cartography
GoldenPath hg19 (UCSC)ARPC1A  -     chr7:98923496-98963885 +  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ARPC1A  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblARPC1A - 7q22.1 [CytoView hg19]  ARPC1A - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIARPC1A [Mapview hg19]  ARPC1A [Mapview hg38]
OMIM604220   
Gene and transcription
Genbank (Entrez)AB209059 AK223015 BC006445 BC039594 BC047889
RefSeq transcript (Entrez)NM_001190996 NM_006409
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)ARPC1A
Cluster EST : UnigeneHs.124126 [ NCBI ]
CGAP (NCI)Hs.124126
Alternative Splicing GalleryENSG00000241685
Gene ExpressionARPC1A [ NCBI-GEO ]   ARPC1A [ EBI - ARRAY_EXPRESS ]   ARPC1A [ SEEK ]   ARPC1A [ MEM ]
Gene Expression Viewer (FireBrowse)ARPC1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10552
GTEX Portal (Tissue expression)ARPC1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92747   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92747  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92747
Splice isoforms : SwissVarQ92747
PhosPhoSitePlusQ92747
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)ARC1A    ARPC1    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)ARPC1A
DMDM Disease mutations10552
Blocks (Seattle)ARPC1A
SuperfamilyQ92747
Human Protein AtlasENSG00000241685
Peptide AtlasQ92747
HPRD07252
IPIIPI00333068   IPI00909730   IPI00983530   IPI00927330   IPI00926706   
Protein Interaction databases
DIP (DOE-UCLA)Q92747
IntAct (EBI)Q92747
FunCoupENSG00000241685
BioGRIDARPC1A
STRING (EMBL)ARPC1A
ZODIACARPC1A
Ontologies - Pathways
QuickGOQ92747
Ontology : AmiGOactin binding  cytosol  Arp2/3 protein complex  actin cytoskeleton  actin cytoskeleton organization  Arp2/3 complex-mediated actin nucleation  muscle cell projection membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  ephrin receptor signaling pathway  actin filament binding  extracellular exosome  
Ontology : EGO-EBIactin binding  cytosol  Arp2/3 protein complex  actin cytoskeleton  actin cytoskeleton organization  Arp2/3 complex-mediated actin nucleation  muscle cell projection membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  ephrin receptor signaling pathway  actin filament binding  extracellular exosome  
Pathways : KEGGFc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    Shigellosis    Salmonella infection   
NDEx NetworkARPC1A
Atlas of Cancer Signalling NetworkARPC1A
Wikipedia pathwaysARPC1A
Orthology - Evolution
OrthoDB10552
GeneTree (enSembl)ENSG00000241685
Phylogenetic Trees/Animal Genes : TreeFamARPC1A
HOVERGENQ92747
HOGENOMQ92747
Homologs : HomoloGeneARPC1A
Homology/Alignments : Family Browser (UCSC)ARPC1A
Gene fusions - Rearrangements
Fusion : MitelmanARPC1A/TRRAP [7q22.1/7q22.1]  
Fusion: TCGAARPC1A 7q22.1 TRRAP 7q22.1 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARPC1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARPC1A
dbVarARPC1A
ClinVarARPC1A
1000_GenomesARPC1A 
Exome Variant ServerARPC1A
ExAC (Exome Aggregation Consortium)ARPC1A (select the gene name)
Genetic variants : HAPMAP10552
Genomic Variants (DGV)ARPC1A [DGVbeta]
DECIPHER (Syndromes)7:98923496-98963885  ENSG00000241685
CONAN: Copy Number AnalysisARPC1A 
Mutations
ICGC Data PortalARPC1A 
TCGA Data PortalARPC1A 
Broad Tumor PortalARPC1A
OASIS PortalARPC1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARPC1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARPC1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARPC1A
DgiDB (Drug Gene Interaction Database)ARPC1A
DoCM (Curated mutations)ARPC1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARPC1A (select a term)
intoGenARPC1A
Cancer3DARPC1A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604220   
Orphanet
MedgenARPC1A
Genetic Testing Registry ARPC1A
NextProtQ92747 [Medical]
TSGene10552
GENETestsARPC1A
Huge Navigator ARPC1A [HugePedia]
snp3D : Map Gene to Disease10552
BioCentury BCIQARPC1A
ClinGenARPC1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10552
Chemical/Pharm GKB GenePA24997
Clinical trialARPC1A
Miscellaneous
canSAR (ICR)ARPC1A (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARPC1A
EVEXARPC1A
GoPubMedARPC1A
iHOPARPC1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:56:36 CET 2017

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