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ARPC2 (actin related protein 2/3 complex subunit 2)

Identity

Alias_namesactin related protein 2/3 complex, subunit 2 (34 kD)
actin related protein 2/3 complex subunit 2, 34kDa
Alias_symbol (synonym)p34-Arc
ARC34
Other aliasPNAS-139
PRO2446
HGNC (Hugo) ARPC2
LocusID (NCBI) 10109
Atlas_Id 46295
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218217397 and ends at 218254348 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AAMP (2q35) / ARPC2 (2q35)ARPC2 (2q35) / ARPC2 (2q35)ARPC2 (2q35) / CHDH (3p21.1)
ARPC2 (2q35) / CRTAP (3p22.3)ARPC2 (2q35) / TIMP2 (17q25.3)CDC20B (5q11.2) / ARPC2 (2q35)
LTBP3 (11q13.1) / ARPC2 (2q35)SNRPN (15q11.2) / ARPC2 (2q35)TXNDC15 (5q31.1) / ARPC2 (2q35)
URM1 (9q34.11) / ARPC2 (2q35)USP31 (16p12.2) / ARPC2 (2q35)TXNDC15 5q31.1 / ARPC2 2q35

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARPC2   705
Cards
Entrez_Gene (NCBI)ARPC2  10109  actin related protein 2/3 complex subunit 2
AliasesARC34; PNAS-139; PRO2446; p34-Arc
GeneCards (Weizmann)ARPC2
Ensembl hg19 (Hinxton)ENSG00000163466 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163466 [Gene_View]  chr2:218217397-218254348 [Contig_View]  ARPC2 [Vega]
ICGC DataPortalENSG00000163466
TCGA cBioPortalARPC2
AceView (NCBI)ARPC2
Genatlas (Paris)ARPC2
WikiGenes10109
SOURCE (Princeton)ARPC2
Genetics Home Reference (NIH)ARPC2
Genomic and cartography
GoldenPath hg38 (UCSC)ARPC2  -     chr2:218217397-218254348 +  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARPC2  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblARPC2 - 2q35 [CytoView hg19]  ARPC2 - 2q35 [CytoView hg38]
Mapping of homologs : NCBIARPC2 [Mapview hg19]  ARPC2 [Mapview hg38]
OMIM604224   
Gene and transcription
Genbank (Entrez)AF006085 AF279893 AK092520 AK093625 AK290268
RefSeq transcript (Entrez)NM_005731 NM_152862
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARPC2
Cluster EST : UnigeneHs.529303 [ NCBI ]
CGAP (NCI)Hs.529303
Alternative Splicing GalleryENSG00000163466
Gene ExpressionARPC2 [ NCBI-GEO ]   ARPC2 [ EBI - ARRAY_EXPRESS ]   ARPC2 [ SEEK ]   ARPC2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARPC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10109
GTEX Portal (Tissue expression)ARPC2
Human Protein AtlasENSG00000163466-ARPC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15144   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15144  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15144
Splice isoforms : SwissVarO15144
PhosPhoSitePlusO15144
Domains : Interpro (EBI)ARPC2   
Domain families : Pfam (Sanger)P34-Arc (PF04045)   
Domain families : Pfam (NCBI)pfam04045   
Conserved Domain (NCBI)ARPC2
DMDM Disease mutations10109
Blocks (Seattle)ARPC2
SuperfamilyO15144
Human Protein Atlas [tissue]ENSG00000163466-ARPC2 [tissue]
Peptide AtlasO15144
HPRD10367
IPIIPI00005161   IPI00000477   IPI00926315   IPI00925705   IPI00925920   IPI00927156   
Protein Interaction databases
DIP (DOE-UCLA)O15144
IntAct (EBI)O15144
FunCoupENSG00000163466
BioGRIDARPC2
STRING (EMBL)ARPC2
ZODIACARPC2
Ontologies - Pathways
QuickGOO15144
Ontology : AmiGOstructural constituent of cytoskeleton  protein binding  endosome  cytosol  Arp2/3 protein complex  focal adhesion  movement of cell or subcellular component  positive regulation of lamellipodium assembly  actin cytoskeleton  actin filament polymerization  cell leading edge  Arp2/3 complex-mediated actin nucleation  muscle cell projection membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  neuron projection  synapse  ephrin receptor signaling pathway  actin filament binding  membrane organization  extracellular exosome  positive regulation of substrate adhesion-dependent cell spreading  
Ontology : EGO-EBIstructural constituent of cytoskeleton  protein binding  endosome  cytosol  Arp2/3 protein complex  focal adhesion  movement of cell or subcellular component  positive regulation of lamellipodium assembly  actin cytoskeleton  actin filament polymerization  cell leading edge  Arp2/3 complex-mediated actin nucleation  muscle cell projection membrane  Fc-gamma receptor signaling pathway involved in phagocytosis  neuron projection  synapse  ephrin receptor signaling pathway  actin filament binding  membrane organization  extracellular exosome  positive regulation of substrate adhesion-dependent cell spreading  
Pathways : KEGGFc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    Shigellosis    Salmonella infection   
NDEx NetworkARPC2
Atlas of Cancer Signalling NetworkARPC2
Wikipedia pathwaysARPC2
Orthology - Evolution
OrthoDB10109
GeneTree (enSembl)ENSG00000163466
Phylogenetic Trees/Animal Genes : TreeFamARPC2
HOVERGENO15144
HOGENOMO15144
Homologs : HomoloGeneARPC2
Homology/Alignments : Family Browser (UCSC)ARPC2
Gene fusions - Rearrangements
Fusion : MitelmanTXNDC15/ARPC2 [5q31.1/2q35]  [t(2;5)(q35;q31)]  
Fusion: TCGATXNDC15 5q31.1 ARPC2 2q35 GBM
Fusion: Tumor Portal ARPC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARPC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARPC2
dbVarARPC2
ClinVarARPC2
1000_GenomesARPC2 
Exome Variant ServerARPC2
ExAC (Exome Aggregation Consortium)ENSG00000163466
GNOMAD BrowserENSG00000163466
Genetic variants : HAPMAP10109
Genomic Variants (DGV)ARPC2 [DGVbeta]
DECIPHERARPC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARPC2 
Mutations
ICGC Data PortalARPC2 
TCGA Data PortalARPC2 
Broad Tumor PortalARPC2
OASIS PortalARPC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARPC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARPC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARPC2
DgiDB (Drug Gene Interaction Database)ARPC2
DoCM (Curated mutations)ARPC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARPC2 (select a term)
intoGenARPC2
Cancer3DARPC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604224   
Orphanet
MedgenARPC2
Genetic Testing Registry ARPC2
NextProtO15144 [Medical]
TSGene10109
GENETestsARPC2
Target ValidationARPC2
Huge Navigator ARPC2 [HugePedia]
snp3D : Map Gene to Disease10109
BioCentury BCIQARPC2
ClinGenARPC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10109
Chemical/Pharm GKB GenePA24999
Clinical trialARPC2
Miscellaneous
canSAR (ICR)ARPC2 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARPC2
EVEXARPC2
GoPubMedARPC2
iHOPARPC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:41:01 CET 2017

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