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ARPC3 (actin related protein 2/3 complex, subunit 3, 21kDa)

Identity

Alias_namesactin related protein 2/3 complex, subunit 3 (21 kD)
actin related protein 2/3 complex subunit 3, 21kDa
Alias_symbol (synonym)p21-Arc
ARC21
Other alias
HGNC (Hugo) ARPC3
LocusID (NCBI) 10094
Atlas_Id 60521
Location 12q24.11  [Link to chromosome band 12q24]
Location_base_pair Starts at 110872695 and ends at 110888216 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANXA1 (9q21.13) / ARPC3 (12q24.11)ARPC3 (12q24.11) / ARPC3 (12q24.11)ARPC3 (12q24.11) / DPYSL5 (2p23.3)
GPN3 (12q24.11) / ARPC3 (12q24.11)SEPT7 (7p14.2) / ARPC3 (12q24.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARPC3   706
Cards
Entrez_Gene (NCBI)ARPC3  10094  actin related protein 2/3 complex, subunit 3, 21kDa
AliasesARC21; p21-Arc
GeneCards (Weizmann)ARPC3
Ensembl hg19 (Hinxton)ENSG00000111229 [Gene_View]  chr12:110872695-110888216 [Contig_View]  ARPC3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111229 [Gene_View]  chr12:110872695-110888216 [Contig_View]  ARPC3 [Vega]
ICGC DataPortalENSG00000111229
TCGA cBioPortalARPC3
AceView (NCBI)ARPC3
Genatlas (Paris)ARPC3
WikiGenes10094
SOURCE (Princeton)ARPC3
Genetics Home Reference (NIH)ARPC3
Genomic and cartography
GoldenPath hg19 (UCSC)ARPC3  -     chr12:110872695-110888216 -  12q24.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ARPC3  -     12q24.11   [Description]    (hg38-Dec_2013)
EnsemblARPC3 - 12q24.11 [CytoView hg19]  ARPC3 - 12q24.11 [CytoView hg38]
Mapping of homologs : NCBIARPC3 [Mapview hg19]  ARPC3 [Mapview hg38]
OMIM604225   
Gene and transcription
Genbank (Entrez)AF004561 AF006086 AI144468 AK297309 AK311789
RefSeq transcript (Entrez)NM_001278556 NM_001287222
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929385
Consensus coding sequences : CCDS (NCBI)ARPC3
Cluster EST : UnigeneHs.524741 [ NCBI ]
CGAP (NCI)Hs.524741
Alternative Splicing GalleryENSG00000111229
Gene ExpressionARPC3 [ NCBI-GEO ]   ARPC3 [ EBI - ARRAY_EXPRESS ]   ARPC3 [ SEEK ]   ARPC3 [ MEM ]
Gene Expression Viewer (FireBrowse)ARPC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10094
GTEX Portal (Tissue expression)ARPC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15145   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15145  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15145
Splice isoforms : SwissVarO15145
PhosPhoSitePlusO15145
Domains : Interpro (EBI)ARPC3   
Domain families : Pfam (Sanger)P21-Arc (PF04062)   
Domain families : Pfam (NCBI)pfam04062   
Conserved Domain (NCBI)ARPC3
DMDM Disease mutations10094
Blocks (Seattle)ARPC3
SuperfamilyO15145
Human Protein AtlasENSG00000111229
Peptide AtlasO15145
HPRD09175
IPIIPI00005162   IPI00911088   IPI01022848   IPI00796102   
Protein Interaction databases
DIP (DOE-UCLA)O15145
IntAct (EBI)O15145
FunCoupENSG00000111229
BioGRIDARPC3
STRING (EMBL)ARPC3
ZODIACARPC3
Ontologies - Pathways
QuickGOO15145
Ontology : AmiGOstructural constituent of cytoskeleton  protein binding  cytosol  Arp2/3 protein complex  focal adhesion  movement of cell or subcellular component  small GTPase mediated signal transduction  axon guidance  actin cytoskeleton  membrane  lamellipodium  Arp2/3 complex-mediated actin nucleation  Fc-gamma receptor signaling pathway involved in phagocytosis  innate immune response  ephrin receptor signaling pathway  actin filament binding  extracellular exosome  
Ontology : EGO-EBIstructural constituent of cytoskeleton  protein binding  cytosol  Arp2/3 protein complex  focal adhesion  movement of cell or subcellular component  small GTPase mediated signal transduction  axon guidance  actin cytoskeleton  membrane  lamellipodium  Arp2/3 complex-mediated actin nucleation  Fc-gamma receptor signaling pathway involved in phagocytosis  innate immune response  ephrin receptor signaling pathway  actin filament binding  extracellular exosome  
Pathways : KEGGFc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    Shigellosis    Salmonella infection   
NDEx NetworkARPC3
Atlas of Cancer Signalling NetworkARPC3
Wikipedia pathwaysARPC3
Orthology - Evolution
OrthoDB10094
GeneTree (enSembl)ENSG00000111229
Phylogenetic Trees/Animal Genes : TreeFamARPC3
HOVERGENO15145
HOGENOMO15145
Homologs : HomoloGeneARPC3
Homology/Alignments : Family Browser (UCSC)ARPC3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARPC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARPC3
dbVarARPC3
ClinVarARPC3
1000_GenomesARPC3 
Exome Variant ServerARPC3
ExAC (Exome Aggregation Consortium)ARPC3 (select the gene name)
Genetic variants : HAPMAP10094
Genomic Variants (DGV)ARPC3 [DGVbeta]
DECIPHER (Syndromes)12:110872695-110888216  ENSG00000111229
CONAN: Copy Number AnalysisARPC3 
Mutations
ICGC Data PortalARPC3 
TCGA Data PortalARPC3 
Broad Tumor PortalARPC3
OASIS PortalARPC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARPC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARPC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARPC3
DgiDB (Drug Gene Interaction Database)ARPC3
DoCM (Curated mutations)ARPC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARPC3 (select a term)
intoGenARPC3
Cancer3DARPC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604225   
Orphanet
MedgenARPC3
Genetic Testing Registry ARPC3
NextProtO15145 [Medical]
TSGene10094
GENETestsARPC3
Huge Navigator ARPC3 [HugePedia]
snp3D : Map Gene to Disease10094
BioCentury BCIQARPC3
ClinGenARPC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10094
Chemical/Pharm GKB GenePA25000
Clinical trialARPC3
Miscellaneous
canSAR (ICR)ARPC3 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARPC3
EVEXARPC3
GoPubMedARPC3
iHOPARPC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 11:55:02 CET 2017

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