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ARPC4 (actin related protein 2/3 complex subunit 4)

Identity

Alias_namesactin related protein 2/3 complex, subunit 4 (20 kD)
actin related protein 2/3 complex subunit 4, 20kDa
Alias_symbol (synonym)p20-Arc
ARC20
Other aliasP20-ARC
HGNC (Hugo) ARPC4
LocusID (NCBI) 10093
Atlas_Id 53405
Location 3p25.3  [Link to chromosome band 3p25]
Location_base_pair Starts at 9792495 and ends at 9807105 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARPC4 (3p25.3) / RNF144A (2p25.2)ARPC4 (3p25.3) / TTLL3 (3p25.3)IL17RC (3p25.3) / ARPC4 (3p25.3)
LMF2 (22q13.33) / ARPC4 (3p25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARPC4   707
Cards
Entrez_Gene (NCBI)ARPC4  10093  actin related protein 2/3 complex subunit 4
AliasesARC20; P20-ARC
GeneCards (Weizmann)ARPC4
Ensembl hg19 (Hinxton)ENSG00000241553 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000241553 [Gene_View]  chr3:9792495-9807105 [Contig_View]  ARPC4 [Vega]
ICGC DataPortalENSG00000241553
TCGA cBioPortalARPC4
AceView (NCBI)ARPC4
Genatlas (Paris)ARPC4
WikiGenes10093
SOURCE (Princeton)ARPC4
Genetics Home Reference (NIH)ARPC4
Genomic and cartography
GoldenPath hg38 (UCSC)ARPC4  -     chr3:9792495-9807105 +  3p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARPC4  -     3p25.3   [Description]    (hg19-Feb_2009)
EnsemblARPC4 - 3p25.3 [CytoView hg19]  ARPC4 - 3p25.3 [CytoView hg38]
Mapping of homologs : NCBIARPC4 [Mapview hg19]  ARPC4 [Mapview hg38]
OMIM604226   
Gene and transcription
Genbank (Entrez)AF006087 AF019888 AI612891 AK074205 AW408422
RefSeq transcript (Entrez)NM_001024959 NM_001024960 NM_001198780 NM_005718
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARPC4
Cluster EST : UnigeneHs.323342 [ NCBI ]
CGAP (NCI)Hs.323342
Alternative Splicing GalleryENSG00000241553
Gene ExpressionARPC4 [ NCBI-GEO ]   ARPC4 [ EBI - ARRAY_EXPRESS ]   ARPC4 [ SEEK ]   ARPC4 [ MEM ]
Gene Expression Viewer (FireBrowse)ARPC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10093
GTEX Portal (Tissue expression)ARPC4
Human Protein AtlasENSG00000241553-ARPC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP59998   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP59998  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP59998
Splice isoforms : SwissVarP59998
PhosPhoSitePlusP59998
Domains : Interpro (EBI)ARPC4   
Domain families : Pfam (Sanger)ARPC4 (PF05856)   
Domain families : Pfam (NCBI)pfam05856   
Conserved Domain (NCBI)ARPC4
DMDM Disease mutations10093
Blocks (Seattle)ARPC4
SuperfamilyP59998
Human Protein Atlas [tissue]ENSG00000241553-ARPC4 [tissue]
Peptide AtlasP59998
HPRD10368
Protein Interaction databases
DIP (DOE-UCLA)P59998
IntAct (EBI)P59998
FunCoupENSG00000241553
BioGRIDARPC4
STRING (EMBL)ARPC4
ZODIACARPC4
Ontologies - Pathways
QuickGOP59998
Ontology : AmiGOstructural constituent of cytoskeleton  protein binding  cytosol  Arp2/3 protein complex  enzyme binding  actin filament polymerization  protein binding, bridging  Arp2/3 complex-mediated actin nucleation  Fc-gamma receptor signaling pathway involved in phagocytosis  cell projection  actin nucleation  ephrin receptor signaling pathway  actin filament binding  actin filament binding  membrane organization  extracellular exosome  
Ontology : EGO-EBIstructural constituent of cytoskeleton  protein binding  cytosol  Arp2/3 protein complex  enzyme binding  actin filament polymerization  protein binding, bridging  Arp2/3 complex-mediated actin nucleation  Fc-gamma receptor signaling pathway involved in phagocytosis  cell projection  actin nucleation  ephrin receptor signaling pathway  actin filament binding  actin filament binding  membrane organization  extracellular exosome  
Pathways : KEGGFc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    Shigellosis    Salmonella infection   
NDEx NetworkARPC4
Atlas of Cancer Signalling NetworkARPC4
Wikipedia pathwaysARPC4
Orthology - Evolution
OrthoDB10093
GeneTree (enSembl)ENSG00000241553
Phylogenetic Trees/Animal Genes : TreeFamARPC4
HOVERGENP59998
HOGENOMP59998
Homologs : HomoloGeneARPC4
Homology/Alignments : Family Browser (UCSC)ARPC4
Gene fusions - Rearrangements
Tumor Fusion PortalARPC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARPC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARPC4
dbVarARPC4
ClinVarARPC4
1000_GenomesARPC4 
Exome Variant ServerARPC4
ExAC (Exome Aggregation Consortium)ENSG00000241553
GNOMAD BrowserENSG00000241553
Genetic variants : HAPMAP10093
Genomic Variants (DGV)ARPC4 [DGVbeta]
DECIPHERARPC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARPC4 
Mutations
ICGC Data PortalARPC4 
TCGA Data PortalARPC4 
Broad Tumor PortalARPC4
OASIS PortalARPC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARPC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARPC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARPC4
DgiDB (Drug Gene Interaction Database)ARPC4
DoCM (Curated mutations)ARPC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARPC4 (select a term)
intoGenARPC4
Cancer3DARPC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604226   
Orphanet
DisGeNETARPC4
MedgenARPC4
Genetic Testing Registry ARPC4
NextProtP59998 [Medical]
TSGene10093
GENETestsARPC4
Target ValidationARPC4
Huge Navigator ARPC4 [HugePedia]
snp3D : Map Gene to Disease10093
BioCentury BCIQARPC4
ClinGenARPC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10093
Chemical/Pharm GKB GenePA25002
Clinical trialARPC4
Miscellaneous
canSAR (ICR)ARPC4 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARPC4
EVEXARPC4
GoPubMedARPC4
iHOPARPC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:03:50 CET 2017

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