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ARRB1 (arrestin beta 1)

Identity

Alias_namesARR1
arrestin
Other aliasARB1
HGNC (Hugo) ARRB1
LocusID (NCBI) 408
Atlas_Id 43962
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 75260122 and ends at 75351831 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARRB1 (11q13.4) / ANKFN1 (17q22)ARRB1 (11q13.4) / CCDC90B (11q14.1)ARRB1 (11q13.4) / DLG2 (11q14.1)
ARRB1 (11q13.4) / GAB2 (11q14.1)ARRB1 (11q13.4) / GDPD5 (11q13.4)ARRB1 (11q13.4) / KLHL35 (11q13.4)
ARRB1 (11q13.4) / PAK1 (11q13.5)ARRB1 (11q13.4) / PICALM (11q14.2)ARRB1 (11q13.4) / RASSF3 (12q14.2)
ARRB1 (11q13.4) / UVRAG (11q13.5)RRP12 (10q24.1) / ARRB1 (11q13.4)TRIM44 (11p13) / ARRB1 (11q13.4)
ARRB1 11q13.4 / ANKFN1 17q22ARRB1 11q13.4 / CCDC90B 11q14.1ARRB1 11q13.4 / DLG2 11q14.1
ARRB1 11q13.4 / GAB2 11q14.1ARRB1 11q13.4 / GDPD5 11q13.4ARRB1 11q13.4 / KLHL35 11q13.4
ARRB1 11q13.4 / PAK1 11q13.5ARRB1 11q13.4 / PICALM 11q14.2ARRB1 11q13.4 / RASSF3 12q14.2
ARRB1 11q13.4 / UVRAG 11q13.5

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 10 ]
  ARRB1/GDPD5 (11q13)
ARRB1/KLHL35 (11q13)
ARRB1/UVRAG (11q13)
t(11;11)(q13;q14) ARRB1/CCDC90B
t(11;11)(q13;q14) ARRB1/DLG2
t(11;11)(q13;q14) ARRB1/GAB2
t(11;11)(q13;q14) ARRB1/PAK1
t(11;11)(q13;q14) ARRB1/PICALM
t(11;12)(q13;q14) ARRB1/RASSF3
t(11;17)(q13;q22) ARRB1/ANKFN1


External links

Nomenclature
HGNC (Hugo)ARRB1   711
Cards
Entrez_Gene (NCBI)ARRB1  408  arrestin beta 1
AliasesARB1; ARR1
GeneCards (Weizmann)ARRB1
Ensembl hg19 (Hinxton)ENSG00000137486 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137486 [Gene_View]  ENSG00000137486 [Sequence]  chr11:75260122-75351831 [Contig_View]  ARRB1 [Vega]
ICGC DataPortalENSG00000137486
TCGA cBioPortalARRB1
AceView (NCBI)ARRB1
Genatlas (Paris)ARRB1
WikiGenes408
SOURCE (Princeton)ARRB1
Genetics Home Reference (NIH)ARRB1
Genomic and cartography
GoldenPath hg38 (UCSC)ARRB1  -     chr11:75260122-75351831 -  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARRB1  -     11q13.4   [Description]    (hg19-Feb_2009)
ARRB1 - 11q13.4 [CytoView hg19]  ARRB1 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIARRB1 [Mapview hg19]  ARRB1 [Mapview hg38]
OMIM107940   
Gene and transcription
Genbank (Entrez)AF084040 AF084940 AK074660 AK289718 AK293758
RefSeq transcript (Entrez)NM_004041 NM_020251
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARRB1
Cluster EST : UnigeneHs.625320 [ NCBI ]
CGAP (NCI)Hs.625320
Alternative Splicing GalleryENSG00000137486
Gene ExpressionARRB1 [ NCBI-GEO ]   ARRB1 [ EBI - ARRAY_EXPRESS ]   ARRB1 [ SEEK ]   ARRB1 [ MEM ]
Gene Expression Viewer (FireBrowse)ARRB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)408
GTEX Portal (Tissue expression)ARRB1
Human Protein AtlasENSG00000137486-ARRB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49407   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49407  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49407
Splice isoforms : SwissVarP49407
PhosPhoSitePlusP49407
Domaine pattern : Prosite (Expaxy)ARRESTINS (PS00295)   
Domains : Interpro (EBI)Arrestin    Arrestin-like_N    Arrestin_C    Arrestin_C-like    Arrestin_CS    Arrestin_N    Ig_E-set   
Domain families : Pfam (Sanger)Arrestin_C (PF02752)    Arrestin_N (PF00339)   
Domain families : Pfam (NCBI)pfam02752    pfam00339   
Domain families : Smart (EMBL)Arrestin_C (SM01017)  
Conserved Domain (NCBI)ARRB1
DMDM Disease mutations408
Blocks (Seattle)ARRB1
PDB (RSDB)2IV8   
PDB Europe2IV8   
PDB (PDBSum)2IV8   
PDB (IMB)2IV8   
Structural Biology KnowledgeBase2IV8   
SCOP (Structural Classification of Proteins)2IV8   
CATH (Classification of proteins structures)2IV8   
SuperfamilyP49407
Human Protein Atlas [tissue]ENSG00000137486-ARRB1 [tissue]
Peptide AtlasP49407
HPRD00146
IPIIPI00293857   IPI00336017   IPI01015395   IPI00983541   IPI00982457   IPI00977795   IPI00981809   IPI00984881   
Protein Interaction databases
DIP (DOE-UCLA)P49407
IntAct (EBI)P49407
FunCoupENSG00000137486
BioGRIDARRB1
STRING (EMBL)ARRB1
ZODIACARRB1
Ontologies - Pathways
QuickGOP49407
Ontology : AmiGOGolgi membrane  activation of MAPK activity  chromatin  positive regulation of protein phosphorylation  G protein-coupled receptor internalization  positive regulation of receptor internalization  histone acetyltransferase activity  enzyme inhibitor activity  GTPase activator activity  insulin-like growth factor receptor binding  protein binding  nucleus  nucleoplasm  cytoplasm  lysosomal membrane  endosome  cytosol  plasma membrane  clathrin-coated pit  transcription by RNA polymerase II  ubiquitin-dependent protein catabolic process  apoptotic process  G protein-coupled receptor signaling pathway  phototransduction  transcription factor binding  positive regulation of cell proliferation  postsynaptic density  protein transport  basolateral plasma membrane  protein ubiquitination  histone acetylation  nuclear body  platelet activation  estrogen receptor binding  cytoplasmic vesicle membrane  pseudopodium  negative regulation of protein ubiquitination  positive regulation of protein ubiquitination  cytoplasmic vesicle  mitogen-activated protein kinase kinase binding  ubiquitin protein ligase binding  alpha-1A adrenergic receptor binding  alpha-1B adrenergic receptor binding  angiotensin receptor binding  follicle-stimulating hormone receptor binding  V2 vasopressin receptor binding  negative regulation of NF-kappaB transcription factor activity  positive regulation of protein binding  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  positive regulation of peptidyl-serine phosphorylation  negative regulation of GTPase activity  positive regulation of smooth muscle cell apoptotic process  positive regulation of Rho protein signal transduction  positive regulation of histone acetylation  AP-2 adaptor complex binding  clathrin adaptor activity  positive regulation of insulin secretion involved in cellular response to glucose stimulus  response to drug  follicle-stimulating hormone signaling pathway  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  stress fiber assembly  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  dendritic spine  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of neuron apoptotic process  positive regulation of GTPase activity  transcription regulatory region DNA binding  ion channel binding  postsynaptic membrane  protein phosphorylated amino acid binding  negative regulation of Notch signaling pathway  positive regulation of transcription by RNA polymerase II  membrane organization  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of histone H4 acetylation  arrestin family protein binding  
Ontology : EGO-EBIGolgi membrane  activation of MAPK activity  chromatin  positive regulation of protein phosphorylation  G protein-coupled receptor internalization  positive regulation of receptor internalization  histone acetyltransferase activity  enzyme inhibitor activity  GTPase activator activity  insulin-like growth factor receptor binding  protein binding  nucleus  nucleoplasm  cytoplasm  lysosomal membrane  endosome  cytosol  plasma membrane  clathrin-coated pit  transcription by RNA polymerase II  ubiquitin-dependent protein catabolic process  apoptotic process  G protein-coupled receptor signaling pathway  phototransduction  transcription factor binding  positive regulation of cell proliferation  postsynaptic density  protein transport  basolateral plasma membrane  protein ubiquitination  histone acetylation  nuclear body  platelet activation  estrogen receptor binding  cytoplasmic vesicle membrane  pseudopodium  negative regulation of protein ubiquitination  positive regulation of protein ubiquitination  cytoplasmic vesicle  mitogen-activated protein kinase kinase binding  ubiquitin protein ligase binding  alpha-1A adrenergic receptor binding  alpha-1B adrenergic receptor binding  angiotensin receptor binding  follicle-stimulating hormone receptor binding  V2 vasopressin receptor binding  negative regulation of NF-kappaB transcription factor activity  positive regulation of protein binding  negative regulation of interleukin-6 production  negative regulation of interleukin-8 production  positive regulation of peptidyl-serine phosphorylation  negative regulation of GTPase activity  positive regulation of smooth muscle cell apoptotic process  positive regulation of Rho protein signal transduction  positive regulation of histone acetylation  AP-2 adaptor complex binding  clathrin adaptor activity  positive regulation of insulin secretion involved in cellular response to glucose stimulus  response to drug  follicle-stimulating hormone signaling pathway  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  stress fiber assembly  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  dendritic spine  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of neuron apoptotic process  positive regulation of GTPase activity  transcription regulatory region DNA binding  ion channel binding  postsynaptic membrane  protein phosphorylated amino acid binding  negative regulation of Notch signaling pathway  positive regulation of transcription by RNA polymerase II  membrane organization  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of histone H4 acetylation  arrestin family protein binding  
Pathways : KEGGMAPK signaling pathway    Chemokine signaling pathway    Endocytosis    Phototransduction    Morphine addiction   
NDEx NetworkARRB1
Atlas of Cancer Signalling NetworkARRB1
Wikipedia pathwaysARRB1
Orthology - Evolution
OrthoDB408
GeneTree (enSembl)ENSG00000137486
Phylogenetic Trees/Animal Genes : TreeFamARRB1
HOGENOMP49407
Homologs : HomoloGeneARRB1
Homology/Alignments : Family Browser (UCSC)ARRB1
Gene fusions - Rearrangements
Fusion : MitelmanARRB1/ANKFN1 [11q13.4/17q22]  
Fusion : MitelmanARRB1/CCDC90B [11q13.4/11q14.1]  [t(11;11)(q13;q14)]  
Fusion : MitelmanARRB1/DLG2 [11q13.4/11q14.1]  [t(11;11)(q13;q14)]  
Fusion : MitelmanARRB1/GAB2 [11q13.4/11q14.1]  [t(11;11)(q13;q14)]  
Fusion : MitelmanARRB1/GDPD5 [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanARRB1/KLHL35 [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanARRB1/PAK1 [11q13.4/11q13.5]  [t(11;11)(q13;q14)]  
Fusion : MitelmanARRB1/PICALM [11q13.4/11q14.2]  [t(11;11)(q13;q14)]  
Fusion : MitelmanARRB1/RASSF3 [11q13.4/12q14.2]  [t(11;12)(q13;q14)]  
Fusion : MitelmanARRB1/UVRAG [11q13.4/11q13.5]  [t(11;11)(q13;q13)]  
Fusion PortalARRB1 11q13.4 ANKFN1 17q22 BRCA
Fusion PortalARRB1 11q13.4 CCDC90B 11q14.1 SKCM
Fusion PortalARRB1 11q13.4 DLG2 11q14.1 LUAD
Fusion PortalARRB1 11q13.4 GAB2 11q14.1 BRCA
Fusion PortalARRB1 11q13.4 GDPD5 11q13.4 BRCA LUAD
Fusion PortalARRB1 11q13.4 KLHL35 11q13.4 LUAD
Fusion PortalARRB1 11q13.4 PAK1 11q13.5 BRCA
Fusion PortalARRB1 11q13.4 PICALM 11q14.2 BRCA
Fusion PortalARRB1 11q13.4 RASSF3 12q14.2 BRCA
Fusion PortalARRB1 11q13.4 UVRAG 11q13.5 BRCA
Fusion : QuiverARRB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARRB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARRB1
dbVarARRB1
ClinVarARRB1
1000_GenomesARRB1 
Exome Variant ServerARRB1
ExAC (Exome Aggregation Consortium)ENSG00000137486
GNOMAD BrowserENSG00000137486
Varsome BrowserARRB1
Genetic variants : HAPMAP408
Genomic Variants (DGV)ARRB1 [DGVbeta]
DECIPHERARRB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARRB1 
Mutations
ICGC Data PortalARRB1 
TCGA Data PortalARRB1 
Broad Tumor PortalARRB1
OASIS PortalARRB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARRB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARRB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARRB1
DgiDB (Drug Gene Interaction Database)ARRB1
DoCM (Curated mutations)ARRB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARRB1 (select a term)
intoGenARRB1
Cancer3DARRB1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107940   
Orphanet
DisGeNETARRB1
MedgenARRB1
Genetic Testing Registry ARRB1
NextProtP49407 [Medical]
TSGene408
GENETestsARRB1
Target ValidationARRB1
Huge Navigator ARRB1 [HugePedia]
snp3D : Map Gene to Disease408
BioCentury BCIQARRB1
ClinGenARRB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD408
Chemical/Pharm GKB GenePA59
Clinical trialARRB1
Miscellaneous
canSAR (ICR)ARRB1 (select the gene name)
DataMed IndexARRB1
Probes
Litterature
PubMed241 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARRB1
EVEXARRB1
GoPubMedARRB1
iHOPARRB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 21 15:36:48 CET 2019

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