Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ARRB2 (arrestin beta 2)

Identity

Alias_namesARR2
arrestin
Alias_symbol (synonym)BARR2
DKFZp686L0365
Other aliasARB2
HGNC (Hugo) ARRB2
LocusID (NCBI) 409
Atlas_Id 708
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 4710494 and ends at 4721500 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		ARRB2 (17p13.2) / ANO7 (2q37.3)ARRB2 (17p13.2) / ARRB2 (17p13.2)CEP295 (11q21) / ARRB2 (17p13.2)
TYK2 (19p13.2) / ARRB2 (17p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ARRB2   712
Cards
Entrez_Gene (NCBI)ARRB2  409  arrestin beta 2
AliasesARB2; ARR2; BARR2
GeneCards (Weizmann)ARRB2
Ensembl hg19 (Hinxton)ENSG00000141480 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141480 [Gene_View]  chr17:4710494-4721500 [Contig_View]  ARRB2 [Vega]
ICGC DataPortalENSG00000141480
TCGA cBioPortalARRB2
AceView (NCBI)ARRB2
Genatlas (Paris)ARRB2
WikiGenes409
SOURCE (Princeton)ARRB2
Genetics Home Reference (NIH)ARRB2
Genomic and cartography
GoldenPath hg38 (UCSC)ARRB2  -     chr17:4710494-4721500 +  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARRB2  -     17p13.2   [Description]    (hg19-Feb_2009)
EnsemblARRB2 - 17p13.2 [CytoView hg19]  ARRB2 - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBIARRB2 [Mapview hg19]  ARRB2 [Mapview hg38]
OMIM107941   
Gene and transcription
Genbank (Entrez)AB209786 AF106941 AK097542 AK290951 AK297059
RefSeq transcript (Entrez)NM_001257328 NM_001257329 NM_001257330 NM_001257331 NM_001330064 NM_004313 NM_199004
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARRB2
Cluster EST : UnigeneHs.435811 [ NCBI ]
CGAP (NCI)Hs.435811
Alternative Splicing GalleryENSG00000141480
Gene ExpressionARRB2 [ NCBI-GEO ]   ARRB2 [ EBI - ARRAY_EXPRESS ]   ARRB2 [ SEEK ]   ARRB2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARRB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)409
GTEX Portal (Tissue expression)ARRB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32121   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32121  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32121
Splice isoforms : SwissVarP32121
PhosPhoSitePlusP32121
Domaine pattern : Prosite (Expaxy)ARRESTINS (PS00295)   
Domains : Interpro (EBI)Arrestin    Arrestin-like_N    Arrestin_C    Arrestin_C-like    Arrestin_CS    Arrestin_N    Ig_E-set   
Domain families : Pfam (Sanger)Arrestin_C (PF02752)    Arrestin_N (PF00339)   
Domain families : Pfam (NCBI)pfam02752    pfam00339   
Domain families : Smart (EMBL)Arrestin_C (SM01017)  
Conserved Domain (NCBI)ARRB2
DMDM Disease mutations409
Blocks (Seattle)ARRB2
SuperfamilyP32121
Human Protein AtlasENSG00000141480
Peptide AtlasP32121
HPRD00147
IPIIPI00180375   IPI00783893   IPI00786904   IPI00908307   IPI01013365   IPI00395607   
Protein Interaction databases
DIP (DOE-UCLA)P32121
IntAct (EBI)P32121
FunCoupENSG00000141480
BioGRIDARRB2
STRING (EMBL)ARRB2
ZODIACARRB2
Ontologies - Pathways
QuickGOP32121
Ontology : AmiGOG-protein coupled receptor binding  negative regulation of protein phosphorylation  G-protein coupled receptor internalization  G-protein coupled receptor internalization  G-protein coupled receptor internalization  desensitization of G-protein coupled receptor protein signaling pathway by arrestin  positive regulation of receptor internalization  receptor binding  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  clathrin-coated pit  transcription from RNA polymerase II promoter  transforming growth factor beta receptor signaling pathway  dopamine receptor signaling pathway  brain development  adult walking behavior  positive regulation of gene expression  postsynaptic density  protein transport  basolateral plasma membrane  protein ubiquitination  protein deubiquitination  enzyme binding  protein domain specific binding  endocytic vesicle  platelet activation  negative regulation of protein ubiquitination  positive regulation of protein ubiquitination  cytoplasmic vesicle  receptor internalization  ubiquitin protein ligase binding  alpha-1A adrenergic receptor binding  alpha-1B adrenergic receptor binding  angiotensin receptor binding  type 1 angiotensin receptor binding  D1 dopamine receptor binding  follicle-stimulating hormone receptor binding  type 2A serotonin receptor binding  platelet activating factor receptor binding  negative regulation of NF-kappaB transcription factor activity  positive regulation of synaptic transmission, dopaminergic  protein complex binding  negative regulation of interleukin-1 beta production  negative regulation of interleukin-12 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  protein complex scaffold  positive regulation of peptidyl-serine phosphorylation  negative regulation of toll-like receptor signaling pathway  negative regulation of GTPase activity  negative regulation of smooth muscle cell apoptotic process  follicle-stimulating hormone signaling pathway  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  dendritic spine  intracellular membrane-bounded organelle  protein kinase B binding  postsynaptic membrane  negative regulation of natural killer cell mediated cytotoxicity  positive regulation of peptidyl-tyrosine phosphorylation  detection of temperature stimulus involved in sensory perception of pain  mitogen-activated protein kinase binding  positive regulation of protein kinase B signaling  negative regulation of protein kinase B signaling  positive regulation of calcium ion transport  Wnt signaling pathway, planar cell polarity pathway  cell chemotaxis  regulation of androgen receptor signaling pathway  membrane organization  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  14-3-3 protein binding  negative regulation of release of cytochrome c from mitochondria  chemical synaptic transmission, postsynaptic  positive regulation of DNA biosynthetic process  positive regulation of cardiac muscle cell differentiation  
Ontology : EGO-EBIG-protein coupled receptor binding  negative regulation of protein phosphorylation  G-protein coupled receptor internalization  G-protein coupled receptor internalization  G-protein coupled receptor internalization  desensitization of G-protein coupled receptor protein signaling pathway by arrestin  positive regulation of receptor internalization  receptor binding  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  clathrin-coated pit  transcription from RNA polymerase II promoter  transforming growth factor beta receptor signaling pathway  dopamine receptor signaling pathway  brain development  adult walking behavior  positive regulation of gene expression  postsynaptic density  protein transport  basolateral plasma membrane  protein ubiquitination  protein deubiquitination  enzyme binding  protein domain specific binding  endocytic vesicle  platelet activation  negative regulation of protein ubiquitination  positive regulation of protein ubiquitination  cytoplasmic vesicle  receptor internalization  ubiquitin protein ligase binding  alpha-1A adrenergic receptor binding  alpha-1B adrenergic receptor binding  angiotensin receptor binding  type 1 angiotensin receptor binding  D1 dopamine receptor binding  follicle-stimulating hormone receptor binding  type 2A serotonin receptor binding  platelet activating factor receptor binding  negative regulation of NF-kappaB transcription factor activity  positive regulation of synaptic transmission, dopaminergic  protein complex binding  negative regulation of interleukin-1 beta production  negative regulation of interleukin-12 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  protein complex scaffold  positive regulation of peptidyl-serine phosphorylation  negative regulation of toll-like receptor signaling pathway  negative regulation of GTPase activity  negative regulation of smooth muscle cell apoptotic process  follicle-stimulating hormone signaling pathway  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  dendritic spine  intracellular membrane-bounded organelle  protein kinase B binding  postsynaptic membrane  negative regulation of natural killer cell mediated cytotoxicity  positive regulation of peptidyl-tyrosine phosphorylation  detection of temperature stimulus involved in sensory perception of pain  mitogen-activated protein kinase binding  positive regulation of protein kinase B signaling  negative regulation of protein kinase B signaling  positive regulation of calcium ion transport  Wnt signaling pathway, planar cell polarity pathway  cell chemotaxis  regulation of androgen receptor signaling pathway  membrane organization  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  14-3-3 protein binding  negative regulation of release of cytochrome c from mitochondria  chemical synaptic transmission, postsynaptic  positive regulation of DNA biosynthetic process  positive regulation of cardiac muscle cell differentiation  
Pathways : KEGGMAPK signaling pathway    Chemokine signaling pathway    Endocytosis    Dopaminergic synapse    Olfactory transduction    Phototransduction    Morphine addiction   
NDEx NetworkARRB2
Atlas of Cancer Signalling NetworkARRB2
Wikipedia pathwaysARRB2
Orthology - Evolution
OrthoDB409
GeneTree (enSembl)ENSG00000141480
Phylogenetic Trees/Animal Genes : TreeFamARRB2
HOVERGENP32121
HOGENOMP32121
Homologs : HomoloGeneARRB2
Homology/Alignments : Family Browser (UCSC)ARRB2
Gene fusions - Rearrangements
Fusion Cancer (Beijing)ARRB2 [17p13.2]  -  ANO7 [2q37.3]  [FUSC004224]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARRB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARRB2
dbVarARRB2
ClinVarARRB2
1000_GenomesARRB2 
Exome Variant ServerARRB2
ExAC (Exome Aggregation Consortium)ARRB2 (select the gene name)
Genetic variants : HAPMAP409
Genomic Variants (DGV)ARRB2 [DGVbeta]
DECIPHERARRB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARRB2 
Mutations
ICGC Data PortalARRB2 
TCGA Data PortalARRB2 
Broad Tumor PortalARRB2
OASIS PortalARRB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARRB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARRB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARRB2
DgiDB (Drug Gene Interaction Database)ARRB2
DoCM (Curated mutations)ARRB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARRB2 (select a term)
intoGenARRB2
Cancer3DARRB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107941   
Orphanet
MedgenARRB2
Genetic Testing Registry ARRB2
NextProtP32121 [Medical]
TSGene409
GENETestsARRB2
Target ValidationARRB2
Huge Navigator ARRB2 [HugePedia]
snp3D : Map Gene to Disease409
BioCentury BCIQARRB2
ClinGenARRB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD409
Chemical/Pharm GKB GenePA60
Clinical trialARRB2
Miscellaneous
canSAR (ICR)ARRB2 (select the gene name)
Probes
Litterature
PubMed275 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARRB2
EVEXARRB2
GoPubMedARRB2
iHOPARRB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:55:30 CEST 2017
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