ARRDC3 (arrestin domain containing 3)

2010-10-01  

Identity

HGNC
ARRDC3
LOCATION
5q14.3
LOCUSID
57561
ALIAS
TLIMP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57561
MIM: 612464
HGNC: 29263
Ensembl: ENSG00000113369

Variants:

dbSNP: 57561
ClinVar: 57561
TCGA: ENSG00000113369
COSMIC: ARRDC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113369ENST00000265138Q96B67

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
205593252010Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.83
196053642009Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.75
232085502013Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking.48
219827432011The arrestin domain-containing 3 protein regulates body mass and energy expenditure.44
206036142010ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4.42
203062912010A three-stage genome-wide association study of general cognitive ability: hunting the small effects.36
162694622006Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling.27
243794092014Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3).25
216525782012Genetic polymorphisms in androgen receptor-binding sites predict survival in prostate cancer patients receiving androgen-deprivation therapy.22
272265652016The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.17

Citation

Dessen P

ARRDC3 (arrestin domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51690/arrdc3