Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ARSB (arylsulfatase B)

Identity

Other aliasASB
G4S
MPS6
HGNC (Hugo) ARSB
LocusID (NCBI) 411
Atlas_Id 54136
Location 5q14.1  [Link to chromosome band 5q14]
Location_base_pair Starts at 78777211 and ends at 78986534 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARSB (5q14.1) / DENND2A (7q34)ARSB (5q14.1) / DMGDH (5q14.1)ARSB (5q14.1) / NALCN (13q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARSB   714
Cards
Entrez_Gene (NCBI)ARSB  411  arylsulfatase B
AliasesASB; G4S; MPS6
GeneCards (Weizmann)ARSB
Ensembl hg19 (Hinxton)ENSG00000113273 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113273 [Gene_View]  chr5:78777211-78986534 [Contig_View]  ARSB [Vega]
ICGC DataPortalENSG00000113273
TCGA cBioPortalARSB
AceView (NCBI)ARSB
Genatlas (Paris)ARSB
WikiGenes411
SOURCE (Princeton)ARSB
Genetics Home Reference (NIH)ARSB
Genomic and cartography
GoldenPath hg38 (UCSC)ARSB  -     chr5:78777211-78986534 -  5q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARSB  -     5q14.1   [Description]    (hg19-Feb_2009)
EnsemblARSB - 5q14.1 [CytoView hg19]  ARSB - 5q14.1 [CytoView hg38]
Mapping of homologs : NCBIARSB [Mapview hg19]  ARSB [Mapview hg38]
OMIM253200   611542   
Gene and transcription
Genbank (Entrez)AI244301 AI457798 AI821478 AK026942 AK290865
RefSeq transcript (Entrez)NM_000046 NM_198709
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARSB
Cluster EST : UnigeneHs.604199 [ NCBI ]
CGAP (NCI)Hs.604199
Alternative Splicing GalleryENSG00000113273
Gene ExpressionARSB [ NCBI-GEO ]   ARSB [ EBI - ARRAY_EXPRESS ]   ARSB [ SEEK ]   ARSB [ MEM ]
Gene Expression Viewer (FireBrowse)ARSB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)411
GTEX Portal (Tissue expression)ARSB
Human Protein AtlasENSG00000113273-ARSB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15848   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15848  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15848
Splice isoforms : SwissVarP15848
Catalytic activity : Enzyme3.1.6.12 [ Enzyme-Expasy ]   3.1.6.123.1.6.12 [ IntEnz-EBI ]   3.1.6.12 [ BRENDA ]   3.1.6.12 [ KEGG ]   
PhosPhoSitePlusP15848
Domaine pattern : Prosite (Expaxy)SULFATASE_1 (PS00523)    SULFATASE_2 (PS00149)   
Domains : Interpro (EBI)Alkaline_Pase-like_a/b/a    Alkaline_phosphatase_core    Sulfatase_CS    Sulfatase_N   
Domain families : Pfam (Sanger)Sulfatase (PF00884)   
Domain families : Pfam (NCBI)pfam00884   
Conserved Domain (NCBI)ARSB
DMDM Disease mutations411
Blocks (Seattle)ARSB
PDB (SRS)1FSU   
PDB (PDBSum)1FSU   
PDB (IMB)1FSU   
PDB (RSDB)1FSU   
Structural Biology KnowledgeBase1FSU   
SCOP (Structural Classification of Proteins)1FSU   
CATH (Classification of proteins structures)1FSU   
SuperfamilyP15848
Human Protein Atlas [tissue]ENSG00000113273-ARSB [tissue]
Peptide AtlasP15848
HPRD08358
IPIIPI00306576   IPI00413690   IPI00983897   
Protein Interaction databases
DIP (DOE-UCLA)P15848
IntAct (EBI)P15848
FunCoupENSG00000113273
BioGRIDARSB
STRING (EMBL)ARSB
ZODIACARSB
Ontologies - Pathways
QuickGOP15848
Ontology : AmiGON-acetylgalactosamine-4-sulfatase activity  N-acetylgalactosamine-4-sulfatase activity  arylsulfatase activity  extracellular region  mitochondrion  lysosome  endoplasmic reticulum lumen  rough endoplasmic reticulum  Golgi apparatus  glycosphingolipid metabolic process  autophagy  lysosome organization  lysosomal transport  central nervous system development  response to nutrient  response to pH  cell surface  regulation of epithelial cell migration  positive regulation of neuron projection development  chondroitin sulfate catabolic process  azurophil granule lumen  lysosomal lumen  neutrophil degranulation  response to estrogen  post-translational protein modification  metal ion binding  response to methylmercury  colon epithelial cell migration  extracellular exosome  ficolin-1-rich granule lumen  
Ontology : EGO-EBIN-acetylgalactosamine-4-sulfatase activity  N-acetylgalactosamine-4-sulfatase activity  arylsulfatase activity  extracellular region  mitochondrion  lysosome  endoplasmic reticulum lumen  rough endoplasmic reticulum  Golgi apparatus  glycosphingolipid metabolic process  autophagy  lysosome organization  lysosomal transport  central nervous system development  response to nutrient  response to pH  cell surface  regulation of epithelial cell migration  positive regulation of neuron projection development  chondroitin sulfate catabolic process  azurophil granule lumen  lysosomal lumen  neutrophil degranulation  response to estrogen  post-translational protein modification  metal ion binding  response to methylmercury  colon epithelial cell migration  extracellular exosome  ficolin-1-rich granule lumen  
Pathways : KEGGGlycosaminoglycan degradation    Lysosome   
NDEx NetworkARSB
Atlas of Cancer Signalling NetworkARSB
Wikipedia pathwaysARSB
Orthology - Evolution
OrthoDB411
GeneTree (enSembl)ENSG00000113273
Phylogenetic Trees/Animal Genes : TreeFamARSB
HOVERGENP15848
HOGENOMP15848
Homologs : HomoloGeneARSB
Homology/Alignments : Family Browser (UCSC)ARSB
Gene fusions - Rearrangements
Fusion : MitelmanARSB/DMGDH [5q14.1/5q14.1]  
Tumor Fusion PortalARSB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARSB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARSB
dbVarARSB
ClinVarARSB
1000_GenomesARSB 
Exome Variant ServerARSB
ExAC (Exome Aggregation Consortium)ENSG00000113273
GNOMAD BrowserENSG00000113273
Genetic variants : HAPMAP411
Genomic Variants (DGV)ARSB [DGVbeta]
DECIPHERARSB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARSB 
Mutations
ICGC Data PortalARSB 
TCGA Data PortalARSB 
Broad Tumor PortalARSB
OASIS PortalARSB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARSB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARSB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARSB
DgiDB (Drug Gene Interaction Database)ARSB
DoCM (Curated mutations)ARSB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARSB (select a term)
intoGenARSB
Cancer3DARSB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM253200    611542   
Orphanet20357    20356   
DisGeNETARSB
MedgenARSB
Genetic Testing Registry ARSB
NextProtP15848 [Medical]
TSGene411
GENETestsARSB
Target ValidationARSB
Huge Navigator ARSB [HugePedia]
snp3D : Map Gene to Disease411
BioCentury BCIQARSB
ClinGenARSB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD411
Chemical/Pharm GKB GenePA25006
Clinical trialARSB
Miscellaneous
canSAR (ICR)ARSB (select the gene name)
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARSB
EVEXARSB
GoPubMedARSB
iHOPARSB
Genes in titleautomatic search yn PujM%d
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:03:52 CET 2017

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