Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1)

Written2012-02Hisataka Sabe, Yasuhito Onodera, Ari Hashimoto, Shigeru Hashimoto
Hokkaido University Graduate School of Medicine, Department of Molecular Biology, Sapporo, Japan

(Note : for Links provided by Atlas : click)


HGNC Alias symbPAP
HGNC Alias namecentaurin, beta 4
HGNC Previous nameDDEF1
HGNC Previous namedevelopment and differentiation enhancing factor 1
LocusID (NCBI) 50807
Atlas_Id 44351
Location 8q24.21  [Link to chromosome band 8q24]
Location_base_pair Starts at 130052105 and ends at 130443674 bp from pter ( according to hg19-Feb_2009)  [Mapping ASAP1.png]
  The ASAP1 gene maps on chromosome 8, at 8q24.1-q24.2 according to Entrez Gene (adapted from GeneCards).
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKS1B (12q23.1) / ASAP1 (8q24.21)ASAP1 (8q24.21) / ASAP1 (8q24.21)ASAP1 (8q24.21) / CLVS1 (8q12.2)
ASAP1 (8q24.21) / CLVS1 (8q12.3)ASAP1 (8q24.21) / FAM19A5 (22q13.32)ASAP1 (8q24.21) / KCNH1 (1q32.2)
ASAP1 (8q24.21) / LRRCC1 (8q21.2)ASAP1 (8q24.21) / MALAT1 (11q13.1)ASAP1 (8q24.21) / MDGA2 (14q21.3)
ASAP1 (8q24.21) / P4HA3 (11q13.4)ASAP1 (8q24.21) / PSMD3 (17q21.1)ASAP1 (8q24.21) / RAD51B (14q24.1)
ASAP1 (8q24.21) / ROBO2 (3p12.3)ASAP1 (8q24.21) / SAMD12 (8q24.11)ASAP1 (8q24.21) / SAMD12 (8q24.12)
EFR3A (8q24.22) / ASAP1 (8q24.21)FAM49B (8q24.21) / ASAP1 (8q24.21)MARF1 (16p13.11) / ASAP1 (8q24.21)
PNPT1 (2p16.1) / ASAP1 (8q24.21)PVT1 (8q24.21) / ASAP1 (8q24.21)


Description The ASAP1 locus spans 391,75 kb, on the minus strand of chromosome 8 from 131456099 to 131064346.
Transcription Transcription produces 16 different mRNAs, 12 alternatively spliced variants and 4 unspliced forms.
There are 9 probable alternative promotors, 6 non overlapping alternative last exons and 5 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 15 cassette exons, overlapping exons with different boundaries (NCBI).


Expression Epithelial cells, fibroblasts, macrophages, brain (for references see above), and endothelial cells (Hashimoto et al., 2011). Not determined with the other types of cells.
Localisation Intracellular tubulovesicular structures and vesicles, plasma membrane protrusions and leading edges, and invadopodia/podosome structures (Hashimoto et al., 2004; Hashimoto et al., 2005; Onodera et al., 2005).
Function ASAP1 has an ArfGAP zinc-finger domain and exhibits phosphatidylinositol 4,5-bisphosphate-dependent GAP activities for Arf1 and Arf5 but 102- to 103-fold less activity for Arf6 (Brown et al., 1998; Andreev et al., 1999). ASAP1 was shown to enhance cell motility, and this activity was proposed to be mediated by its GAP activity towards Arf1 (Furman et al., 2002). ASAP1 was also shown to associate with focal adhesion kinase (FAK) and contribute to focal adhesion assembly (Liu et al., 2002). Hashimoto et al. (2004 and 2005) have shown that AMAP1 and AMAP2 have the ability to bind stably with GTP-Arf6, but not GDP-Arf6 or other GTP-/GDP-Arf isoforms, in vitro and in vivo. Through this binding, AMAP1 and AMAP2 appear to function as downstream effectors for GTP-Arf6 (Hashimoto et al., 2004; Hashimoto et al., 2005; Onodera et al., 2005). AMAP1 binds to paxillin and cortactin, which are essential components of the invadopodia of MDA-MB-231 breast cancer cells, and acts to recruit these proteins to the sites of Arf6 activation to form invadopodia (Onodera et al., 2005). AMAP1 is hence essential for invasion and metastasis of some breast cancer cells, while AMAP2 is not a component of invadopodia (Onodera et al., 2005; Hashimoto et al., 2006; Nam et al., 2007; Morishige et al., 2008; Sabe et al., 2009). AMAP1 appears to be a useful diagnostic marker as well as therapeutic target of different types of human cancers (see below).

Implicated in

Entity Breast cancer
Note In primary breast cancers, AMAP1 protein, but not AMAP2 protein, is abnormally overexpressed in their significant population in a manner independent of the transcriptional upregulation of the AMAP1 gene, and levels of AMAP1 protein expression correlates well with the malignant phenotypes (Onodera et al., 2005).
Entity Melanoma
Note With the name DDEF1, this gene was identified to be located in an amplified region of chromosome 8q24.12, and the amplification of chromosome 8q in uveal melanomas was found to correlate most strongly with the expression of this gene in melanomas (Ehlers et al., 2005).
Entity Colorectal cancer
Note Protein expression of ASAP1 is upregulated in colorectal cancer cells, and this expression correlates with poor metastasis-free survival and prognosis in colorectal cancer patients (Müller et al., 2010). It is worth noting, on the other hand, that a previous study on the copy number changes at 8q11-24 in colorectal carcinomas showed that although the MYC gene, located at 8q24.12-q24.13, is indeed amplified and correlates with the advanced stages of colorectal carcinoma, the DDEF1 gene was not amplified (Buffart et al., 2005).
Entity Prostate cancer
Note Additional gene copies of ASAP1 were also detected in a large population of primary prostate cancers, and ASAP1 protein staining was found to be elevated in 80% of primary prostate cancers with substantially higher amounts observed in metastatic lesions compared with benign prostate tissue (Lin et al., 2008).
Entity Pancreatic ductal adenocarcinoma
Note DDEF1 gene was found to be frequently amplified, most likely to be oncogenic, in pancreatic ductal adenocarcinomas, accompanied by enhanced expression of this gene (Harada et al., 2009).
Entity VEGF- and tumor-induced angiogenesis
Note AMAP1 protein is highly expressed in endothelial cells upon their treatment with vascular endothelial growth factor (VEGF), and an essential component of VEGF- and tumor-induced angiogenesis, and also choroidal neovascularization (Hashimoto et al., 2011).


Identification of a new Pyk2 target protein with Arf-GAP activity.
Andreev J, Simon JP, Sabatini DD, Kam J, Plowman G, Randazzo PA, Schlessinger J.
Mol Cell Biol. 1999 Mar;19(3):2338-50.
PMID 10022920
ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.
Brown MT, Andrade J, Radhakrishna H, Donaldson JG, Cooper JA, Randazzo PA.
Mol Cell Biol. 1998 Dec;18(12):7038-51.
PMID 9819391
DNA copy number changes at 8q11-24 in metastasized colorectal cancer.
Buffart TE, Coffa J, Hermsen MA, Carvalho B, van der Sijp JR, Ylstra B, Pals G, Schouten JP, Meijer GA.
Cell Oncol. 2005;27(1):57-65.
PMID 15750208
DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma.
Ehlers JP, Worley L, Onken MD, Harbour JW.
Clin Cancer Res. 2005 May 15;11(10):3609-13.
PMID 15897555
DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.
Furman C, Short SM, Subramanian RR, Zetter BR, Roberts TM.
J Biol Chem. 2002 Mar 8;277(10):7962-9. Epub 2001 Dec 31.
PMID 11773070
Genome-wide analysis of pancreatic cancer using microarray-based techniques.
Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR.
Pancreatology. 2009;9(1-2):13-24. Epub 2008 Dec 12. (REVIEW)
PMID 19077451
GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.
Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, Hirose M, Menju T, Morishige M, Manabe T, Toda Y, Ishida S, Sabe H.
PLoS One. 2011;6(8):e23359. Epub 2011 Aug 15.
PMID 21858086
Assays and properties of the ArfGAPs, AMAP1 and AMAP2, in Arf6 function.
Hashimoto S, Hashimoto A, Yamada A, Onodera Y, Sabe H.
Methods Enzymol. 2005;404:216-31.
PMID 16413272
The ARF Family.
Kahn RA.
ARF Family GTPases, R.A. Kahn ed., Kluwer Acadmic Publishers, 2004.
DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines.
King FJ, Hu E, Harris DF, Sarraf P, Spiegelman BM, Roberts TM.
Mol Cell Biol. 1999 Mar;19(3):2330-7.
PMID 10022919
A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration.
Kondo A, Hashimoto S, Yano H, Nagayama K, Mazaki Y, Sabe H.
Mol Biol Cell. 2000 Apr;11(4):1315-27.
PMID 10749932
ASAP1, a gene at 8q24, is associated with prostate cancer metastasis.
Lin D, Watahiki A, Bayani J, Zhang F, Liu L, Ling V, Sadar MD, English J, Fazli L, So A, Gout PW, Gleave M, Squire JA, Wang YZ.
Cancer Res. 2008 Jun 1;68(11):4352-9.
PMID 18519696
The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.
Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT.
Mol Biol Cell. 2002 Jun;13(6):2147-56.
PMID 12058076
An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization.
Mazaki Y, Hashimoto S, Okawa K, Tsubouchi A, Nakamura K, Yagi R, Yano H, Kondo A, Iwamatsu A, Mizoguchi A, Sabe H.
Mol Biol Cell. 2001 Mar;12(3):645-62.
PMID 11251077
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.
Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, Wei S, Hashimoto A, Yamada A, Yano H, Mazaki Y, Kodama H, Nio Y, Manabe T, Wada H, Kobayashi H, Sabe H.
Nat Cell Biol. 2008 Jan;10(1):85-92. Epub 2007 Dec 16.
PMID 18084281
ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients.
Muller T, Stein U, Poletti A, Garzia L, Rothley M, Plaumann D, Thiele W, Bauer M, Galasso A, Schlag P, Pankratz M, Zollo M, Sleeman JP.
Oncogene. 2010 Apr 22;29(16):2393-403. Epub 2010 Feb 15.
PMID 20154719
CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.
Nam JM, Onodera Y, Mazaki Y, Miyoshi H, Hashimoto S, Sabe H.
EMBO J. 2007 Feb 7;26(3):647-56. Epub 2007 Jan 25.
PMID 17255943
Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.
Onodera Y, Hashimoto S, Hashimoto A, Morishige M, Mazaki Y, Yamada A, Ogawa E, Adachi M, Sakurai T, Manabe T, Wada H, Matsuura N, Sabe H.
EMBO J. 2005 Mar 9;24(5):963-73. Epub 2005 Feb 17.
PMID 15719014
The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.
Sabe H, Hashimoto S, Morishige M, Ogawa E, Hashimoto A, Nam JM, Miura K, Yano H, Onodera Y.
Traffic. 2009 Aug;10(8):982-93. Epub 2009 Apr 21. (REVIEW)
PMID 19416474
ArfGAP family proteins in cell adhesion, migration and tumor invasion.
Sabe H, Onodera Y, Mazaki Y, Hashimoto S.
Curr Opin Cell Biol. 2006 Oct;18(5):558-64. Epub 2006 Aug 9. (REVIEW)
PMID 16904307


This paper should be referenced as such :
Sabe, H ; Onodera, Y ; Hashimoto, A ; Hashimoto, S
ASAP1 (ArfGAP with SH3 domain, ankyrin repeat, PH domain 1)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(7):443-445.
Free journal version : [ pdf ]   [ DOI ]

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;8)(q24;q24) PVT1/ASAP1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  t(1;8)(q32;q24) ASAP1/KCNH1
t(8;8)(q12;q24) ASAP1/CLVS1
t(8;8)(q21;q24) ASAP1/LRRCC1
ASAP1/SAMD12 (8q24)
EFR3A/ASAP1 (8q24)
FAM49B/ASAP1 (8q24)
t(8;11)(q24;q13) ASAP1/MALAT1
t(8;14)(q24;q24) ASAP1/RAD51B

External links

HGNC (Hugo)ASAP1   2720
Entrez_Gene (NCBI)ASAP1  50807  ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
AliasesAMAP1; CENTB4; DDEF1; PAG2; 
GeneCards (Weizmann)ASAP1
Ensembl hg19 (Hinxton)ENSG00000153317 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153317 [Gene_View]  ENSG00000153317 [Sequence]  chr8:130052105-130443674 [Contig_View]  ASAP1 [Vega]
ICGC DataPortalENSG00000153317
TCGA cBioPortalASAP1
Genatlas (Paris)ASAP1
SOURCE (Princeton)ASAP1
Genetics Home Reference (NIH)ASAP1
Genomic and cartography
GoldenPath hg38 (UCSC)ASAP1  -     chr8:130052105-130443674 -  8q24.21-q24.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ASAP1  -     8q24.21-q24.22   [Description]    (hg19-Feb_2009)
GoldenPathASAP1 - 8q24.21-q24.22 [CytoView hg19]  ASAP1 - 8q24.21-q24.22 [CytoView hg38]
genome Data Viewer NCBIASAP1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB033075 AF222859 AI494058 AI656533 AK056811
RefSeq transcript (Entrez)NM_001247996 NM_001362924 NM_001362925 NM_001362926 NM_018482
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ASAP1
Alternative Splicing GalleryENSG00000153317
Gene ExpressionASAP1 [ NCBI-GEO ]   ASAP1 [ EBI - ARRAY_EXPRESS ]   ASAP1 [ SEEK ]   ASAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)ASAP1 [ Firebrowse - Broad ]
GenevisibleExpression of ASAP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50807
GTEX Portal (Tissue expression)ASAP1
Human Protein AtlasENSG00000153317-ASAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULH1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULH1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULH1
Splice isoforms : SwissVarQ9ULH1
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    ARFGAP (PS50115)    PH_DOMAIN (PS50003)    SH3 (PS50002)   
Domains : Interpro (EBI)AH/BAR_dom_sf    Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    ARFGAP/RecO    ArfGAP_dom    ArfGAP_dom_sf    ASAP1_BAR    ASAP1_SH3    PH-like_dom_sf    PH_ASAP    PH_domain    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    ArfGap (PF01412)    PH (PF00169)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam12796    pfam01412    pfam00169    pfam00018   
Domain families : Smart (EMBL)ANK (SM00248)  ArfGap (SM00105)  PH (SM00233)  SH3 (SM00326)  
Conserved Domain (NCBI)ASAP1
DMDM Disease mutations50807
Blocks (Seattle)ASAP1
PDB (RSDB)2D1X    2DA0    2ED1    2RQT    2RQU   
PDB Europe2D1X    2DA0    2ED1    2RQT    2RQU   
PDB (PDBSum)2D1X    2DA0    2ED1    2RQT    2RQU   
PDB (IMB)2D1X    2DA0    2ED1    2RQT    2RQU   
Structural Biology KnowledgeBase2D1X    2DA0    2ED1    2RQT    2RQU   
SCOP (Structural Classification of Proteins)2D1X    2DA0    2ED1    2RQT    2RQU   
CATH (Classification of proteins structures)2D1X    2DA0    2ED1    2RQT    2RQU   
Human Protein Atlas [tissue]ENSG00000153317-ASAP1 [tissue]
Peptide AtlasQ9ULH1
IPIIPI00873747   IPI00376976   IPI00383062   IPI00020541   IPI00974171   IPI00983032   IPI00985418   IPI01010246   IPI00974332   
Protein Interaction databases
IntAct (EBI)Q9ULH1
Ontologies - Pathways
Ontology : AmiGOphosphatidylserine binding  podosome  GTPase activator activity  protein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytosol  cell projection membrane  dendritic spine  positive regulation of GTPase activity  cadherin binding  metal ion binding  cilium assembly  cilium assembly  negative regulation of dendritic spine development  positive regulation of podosome assembly  positive regulation of membrane tubulation  
Ontology : EGO-EBIphosphatidylserine binding  podosome  GTPase activator activity  protein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytosol  cell projection membrane  dendritic spine  positive regulation of GTPase activity  cadherin binding  metal ion binding  cilium assembly  cilium assembly  negative regulation of dendritic spine development  positive regulation of podosome assembly  positive regulation of membrane tubulation  
Pathways : KEGGEndocytosis    Fc gamma R-mediated phagocytosis   
REACTOMEQ9ULH1 [protein]
REACTOME PathwaysR-HSA-5620916 [pathway]   
NDEx NetworkASAP1
Atlas of Cancer Signalling NetworkASAP1
Wikipedia pathwaysASAP1
Orthology - Evolution
GeneTree (enSembl)ENSG00000153317
Phylogenetic Trees/Animal Genes : TreeFamASAP1
Homologs : HomoloGeneASAP1
Homology/Alignments : Family Browser (UCSC)ASAP1
Gene fusions - Rearrangements
Fusion : MitelmanASAP1/CLVS1 [8q24.21/8q12.3]  
Fusion : MitelmanASAP1/KCNH1 [8q24.21/1q32.2]  
Fusion : MitelmanASAP1/LRRCC1 [8q24.21/8q21.2]  
Fusion : MitelmanASAP1/MALAT1 [8q24.21/11q13.1]  
Fusion : MitelmanASAP1/RAD51B [8q24.21/14q24.1]  
Fusion : MitelmanASAP1/SAMD12 [8q24.21/8q24.12]  
Fusion : MitelmanEFR3A/ASAP1 [8q24.22/8q24.21]  
Fusion : MitelmanFAM49B/ASAP1 [8q24.21/8q24.21]  
Fusion : MitelmanPVT1/ASAP1 [8q24.21/8q24.21]  
Fusion PortalASAP1 8q24.21 CLVS1 8q12.3 BRCA
Fusion PortalASAP1 8q24.21 KCNH1 1q32.2 BRCA
Fusion PortalASAP1 8q24.21 LRRCC1 8q21.2 LUAD
Fusion PortalASAP1 8q24.21 RAD51B 14q24.1 LUAD
Fusion PortalASAP1 8q24.21 SAMD12 8q24.12 LUAD
Fusion PortalEFR3A 8q24.22 ASAP1 8q24.21 BRCA
Fusion PortalFAM49B 8q24.21 ASAP1 8q24.21 BRCA
Fusion : Fusion_HubADCY8--ASAP1    ANKS1B--ASAP1    ASAP1--ADCY2    ASAP1--AGO4    ASAP1--ASAP1    ASAP1--ASPH    ASAP1--BTBD1    ASAP1--CDH19    ASAP1--CDKN2B    ASAP1--CHRAC1    ASAP1--CKLF    ASAP1--CLVS1    ASAP1--COX7A2L    ASAP1--CPQ    ASAP1--CTNNB1   
ASAP1--EEF1D    ASAP1--EFR3A    ASAP1--EGLN3    ASAP1--FAM19A5    ASAP1--FBXO32    ASAP1--FGF12    ASAP1--GSPT1    ASAP1--HECTD2    ASAP1--HIGD1A    ASAP1--HOXC5    ASAP1--HSP90AA1    ASAP1--IFLTD1    ASAP1--IMPA2    ASAP1--INO80    ASAP1--KCNH1   
ASAP1--RAD51B    ASAP1--RARS    ASAP1--RHEB    ASAP1--RIMS2    ASAP1--ROBO2    ASAP1--SAMD12    ASAP1--SH2D3C    ASAP1--SLC15A4    ASAP1--STAU2    ASAP1--TBC1D22A    ASAP1--TG    ASAP1--TRAPPC9    ASAP1--WWP1    BACH1--ASAP1    CPQ--ASAP1   
EFR3A--ASAP1    EXT1--ASAP1    FAM49B--ASAP1    KIAA0430--ASAP1    OXR1--ASAP1    PDIK1L--ASAP1    PNISR--ASAP1    PNPT1--ASAP1    SSR2--ASAP1    TRA@--ASAP1    TTC13--ASAP1    UBAC1--ASAP1   
Fusion : QuiverASAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerASAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ASAP1
Exome Variant ServerASAP1
GNOMAD BrowserENSG00000153317
Varsome BrowserASAP1
Genetic variants : HAPMAP50807
Genomic Variants (DGV)ASAP1 [DGVbeta]
DECIPHERASAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisASAP1 
ICGC Data PortalASAP1 
TCGA Data PortalASAP1 
Broad Tumor PortalASAP1
OASIS PortalASAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICASAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DASAP1
Mutations and Diseases : HGMDASAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ASAP1
DgiDB (Drug Gene Interaction Database)ASAP1
DoCM (Curated mutations)ASAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ASAP1 (select a term)
NCG6 (London) select ASAP1
Cancer3DASAP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry ASAP1
NextProtQ9ULH1 [Medical]
Target ValidationASAP1
Huge Navigator ASAP1 [HugePedia]
snp3D : Map Gene to Disease50807
BioCentury BCIQASAP1
Clinical trials, drugs, therapy
Protein Interactions : CTD50807
Pharm GKB GenePA164716055
Clinical trialASAP1
canSAR (ICR)ASAP1 (select the gene name)
DataMed IndexASAP1
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:41:16 CEST 2020

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us