ASB2 (ankyrin repeat and SOCS box containing 2)

2003-12-01 Affiliation

Identity

HGNC

ASB2

LOCATION

14q32.12

LOCUSID

51676

ALIAS

ASB-2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51676
MIM: 605759
HGNC: 16012
Ensembl: ENSG00000100628

Variants:

dbSNP: 51676
ClinVar: 51676
TCGA: ENSG00000100628
COSMIC: ASB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100628	ENST00000315988	Q96Q27
ENSG00000100628	ENST00000555019	Q96Q27
ENSG00000100628	ENST00000555019	A0A024R6E7
ENSG00000100628	ENST00000555287	G3V484
ENSG00000100628	ENST00000555507	G3V2Z2
ENSG00000100628	ENST00000556062	G3V4B2
ENSG00000100628	ENST00000557613	G3V3P8

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

References

Pubmed ID	Year	Title	Citations
18799729	2008	ASB2 targets filamins A and B to proteasomal degradation.	36
22174154	2012	ECSASB2 mediates MLL degradation during hematopoietic differentiation.	25
21119685	2011	Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.	22
21737450	2011	Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells.	8
24052262	2013	ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain.	7
22916308	2012	Filamins but not Janus kinases are substrates of the ASB2α cullin-ring E3 ubiquitin ligase in hematopoietic cells.	4
26537633	2015	Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells.	3
24044920	2013	Phosphorylation of serine 323 of ASB2α is pivotal for the targeting of filamin A to degradation.	1
29955039	2018	High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2.	1
30116272	2018	The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells.	1

Citation

Dessen P

ASB2 (ankyrin repeat and SOCS box containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/711/asb2