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ASCL2 (achaete-scute family bHLH transcription factor 2)

Identity

Alias_namesachaete-scute complex (Drosophila) homolog-like 2
achaete-scute complex-like 2 (Drosophila)
achaete-scute complex homolog 2 (Drosophila)
Alias_symbol (synonym)ASH2
HASH2
bHLHa45
Other aliasMASH2
HGNC (Hugo) ASCL2
LocusID (NCBI) 430
Atlas_Id 45922
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 2268498 and ends at 2270952 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ASCL2   739
Cards
Entrez_Gene (NCBI)ASCL2  430  achaete-scute family bHLH transcription factor 2
AliasesASH2; HASH2; MASH2; bHLHa45
GeneCards (Weizmann)ASCL2
Ensembl hg19 (Hinxton)ENSG00000183734 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183734 [Gene_View]  chr11:2268498-2270952 [Contig_View]  ASCL2 [Vega]
ICGC DataPortalENSG00000183734
TCGA cBioPortalASCL2
AceView (NCBI)ASCL2
Genatlas (Paris)ASCL2
WikiGenes430
SOURCE (Princeton)ASCL2
Genetics Home Reference (NIH)ASCL2
Genomic and cartography
GoldenPath hg38 (UCSC)ASCL2  -     chr11:2268498-2270952 -  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ASCL2  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblASCL2 - 11p15.5 [CytoView hg19]  ASCL2 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIASCL2 [Mapview hg19]  ASCL2 [Mapview hg38]
OMIM601886   
Gene and transcription
Genbank (Entrez)BC028140 BC057801 BC136561 BC136567
RefSeq transcript (Entrez)NM_005170
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ASCL2
Cluster EST : UnigeneHs.152475 [ NCBI ]
CGAP (NCI)Hs.152475
Alternative Splicing GalleryENSG00000183734
Gene ExpressionASCL2 [ NCBI-GEO ]   ASCL2 [ EBI - ARRAY_EXPRESS ]   ASCL2 [ SEEK ]   ASCL2 [ MEM ]
Gene Expression Viewer (FireBrowse)ASCL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)430
GTEX Portal (Tissue expression)ASCL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99929   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99929  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99929
Splice isoforms : SwissVarQ99929
PhosPhoSitePlusQ99929
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)Achaete-scute-rel    bHLH_dom   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)ASCL2
DMDM Disease mutations430
Blocks (Seattle)ASCL2
SuperfamilyQ99929
Human Protein AtlasENSG00000183734
Peptide AtlasQ99929
HPRD03533
IPIIPI00019112   
Protein Interaction databases
DIP (DOE-UCLA)Q99929
IntAct (EBI)Q99929
FunCoupENSG00000183734
BioGRIDASCL2
STRING (EMBL)ASCL2
ZODIACASCL2
Ontologies - Pathways
QuickGOQ99929
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  response to hypoxia  placenta development  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  negative regulation of Schwann cell proliferation  somatic stem cell population maintenance  protein dimerization activity  regulation of neurogenesis  spongiotrophoblast differentiation  spongiotrophoblast layer development  E-box binding  RNA polymerase II transcription factor complex  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  response to hypoxia  placenta development  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  negative regulation of Schwann cell proliferation  somatic stem cell population maintenance  protein dimerization activity  regulation of neurogenesis  spongiotrophoblast differentiation  spongiotrophoblast layer development  E-box binding  RNA polymerase II transcription factor complex  
NDEx NetworkASCL2
Atlas of Cancer Signalling NetworkASCL2
Wikipedia pathwaysASCL2
Orthology - Evolution
OrthoDB430
GeneTree (enSembl)ENSG00000183734
Phylogenetic Trees/Animal Genes : TreeFamASCL2
HOVERGENQ99929
HOGENOMQ99929
Homologs : HomoloGeneASCL2
Homology/Alignments : Family Browser (UCSC)ASCL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerASCL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ASCL2
dbVarASCL2
ClinVarASCL2
1000_GenomesASCL2 
Exome Variant ServerASCL2
ExAC (Exome Aggregation Consortium)ASCL2 (select the gene name)
Genetic variants : HAPMAP430
Genomic Variants (DGV)ASCL2 [DGVbeta]
DECIPHERASCL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisASCL2 
Mutations
ICGC Data PortalASCL2 
TCGA Data PortalASCL2 
Broad Tumor PortalASCL2
OASIS PortalASCL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICASCL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDASCL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ASCL2
DgiDB (Drug Gene Interaction Database)ASCL2
DoCM (Curated mutations)ASCL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ASCL2 (select a term)
intoGenASCL2
Cancer3DASCL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601886   
Orphanet
MedgenASCL2
Genetic Testing Registry ASCL2
NextProtQ99929 [Medical]
TSGene430
GENETestsASCL2
Target ValidationASCL2
Huge Navigator ASCL2 [HugePedia]
snp3D : Map Gene to Disease430
BioCentury BCIQASCL2
ClinGenASCL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD430
Chemical/Pharm GKB GenePA25039
Clinical trialASCL2
Miscellaneous
canSAR (ICR)ASCL2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineASCL2
EVEXASCL2
GoPubMedASCL2
iHOPASCL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:55:32 CEST 2017

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