ASF1B (anti-silencing function 1B histone chaperone)

2007-02-01  

Identity

HGNC
LOCATION
19p13.12
LOCUSID
ALIAS
CIA-II
FUSION GENES

Other Information

Locus ID:

NCBI: 55723
MIM: 609190
HGNC: 20996
Ensembl: ENSG00000105011

Variants:

dbSNP: 55723
ClinVar: 55723
TCGA: ENSG00000105011
COSMIC: ASF1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105011ENST00000263382Q9NVP2
ENSG00000105011ENST00000263382A0A024R7G4
ENSG00000105011ENST00000474890K7ELW9
ENSG00000105011ENST00000589468K7EM93
ENSG00000105011ENST00000590835K7EIL9
ENSG00000105011ENST00000592798K7ES22

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180968072007Regulation of replication fork progression through histone supply and demand.196
202273762010Replication stress interferes with histone recycling and predeposition marking of new histones.117
118976622002Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway.111
244130542014Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.101
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
211790052011Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer.58
231002762013Restoration of microRNA-214 expression reduces growth of myeloma cells through positive regulation of P53 and inhibition of DNA replication.31
201337882010Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components.29
231784552013Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1.27
245988212014Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.24

Citation

Dessen P

ASF1B (anti-silencing function 1B histone chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43879/asf1b