Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ASIC1 (acid sensing ion channel subunit 1)

Identity

Alias (NCBI)ACCN2
ASIC
BNaC2
HGNC (Hugo) ASIC1
HGNC Alias symbBNaC2
hBNaC2
HGNC Previous nameACCN2
HGNC Previous nameamiloride-sensitive cation channel 2, neuronal
 acid-sensing (proton-gated) ion channel 1
 acid sensing (proton gated) ion channel 1
LocusID (NCBI) 41
Atlas_Id 47525
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 50057596 and ends at 50083611 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ASIC1   100
Cards
Entrez_Gene (NCBI)ASIC1    acid sensing ion channel subunit 1
AliasesACCN2; ASIC; BNaC2
GeneCards (Weizmann)ASIC1
Ensembl hg19 (Hinxton)ENSG00000110881 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110881 [Gene_View]  ENSG00000110881 [Sequence]  chr12:50057596-50083611 [Contig_View]  ASIC1 [Vega]
ICGC DataPortalENSG00000110881
TCGA cBioPortalASIC1
AceView (NCBI)ASIC1
Genatlas (Paris)ASIC1
SOURCE (Princeton)ASIC1
Genetics Home Reference (NIH)ASIC1
Genomic and cartography
GoldenPath hg38 (UCSC)ASIC1  -     chr12:50057596-50083611 +  12q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ASIC1  -     12q13.12   [Description]    (hg19-Feb_2009)
GoldenPathASIC1 - 12q13.12 [CytoView hg19]  ASIC1 - 12q13.12 [CytoView hg38]
ImmunoBaseENSG00000110881
genome Data Viewer NCBIASIC1 [Mapview hg19]  
OMIM602866   
Gene and transcription
Genbank (Entrez)AK290010 AK293960 AK311047 AW451342 BC013891
RefSeq transcript (Entrez)NM_001095 NM_001256830 NM_020039
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ASIC1
Alternative Splicing GalleryENSG00000110881
Gene ExpressionASIC1 [ NCBI-GEO ]   ASIC1 [ EBI - ARRAY_EXPRESS ]   ASIC1 [ SEEK ]   ASIC1 [ MEM ]
Gene Expression Viewer (FireBrowse)ASIC1 [ Firebrowse - Broad ]
GenevisibleExpression of ASIC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)41
GTEX Portal (Tissue expression)ASIC1
Human Protein AtlasENSG00000110881-ASIC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78348   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78348  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78348
Splice isoforms : SwissVarP78348
PhosPhoSitePlusP78348
Domaine pattern : Prosite (Expaxy)ASC (PS01206)   
Domains : Interpro (EBI)ENaC    ENaC_chordates    ENaC_CS   
Domain families : Pfam (Sanger)ASC (PF00858)   
Domain families : Pfam (NCBI)pfam00858   
Conserved Domain (NCBI)ASIC1
Blocks (Seattle)ASIC1
PDB (RSDB)6L6I    7CFS    7CFT   
PDB Europe6L6I    7CFS    7CFT   
PDB (PDBSum)6L6I    7CFS    7CFT   
PDB (IMB)6L6I    7CFS    7CFT   
Structural Biology KnowledgeBase6L6I    7CFS    7CFT   
SCOP (Structural Classification of Proteins)6L6I    7CFS    7CFT   
CATH (Classification of proteins structures)6L6I    7CFS    7CFT   
SuperfamilyP78348
Human Protein Atlas [tissue]ENSG00000110881-ASIC1 [tissue]
Peptide AtlasP78348
HPRD04182
IPIIPI00293398   IPI00293399   IPI00796169   IPI01022600   IPI01022429   IPI00973761   
Protein Interaction databases
DIP (DOE-UCLA)P78348
IntAct (EBI)P78348
BioGRIDASIC1
STRING (EMBL)ASIC1
ZODIACASIC1
Ontologies - Pathways
QuickGOP78348
Ontology : AmiGObehavioral fear response  response to amphetamine  protein binding  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  sodium ion transport  signal transduction  memory  associative learning  response to pH  cell surface  response to acidic pH  ligand-gated sodium channel activity  ion gated channel activity  ion transmembrane transport  sodium ion transmembrane transport  sodium ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  acid-sensing ion channel activity  acid-sensing ion channel activity  acid-sensing ion channel activity  synapse  negative regulation of neurotransmitter secretion  sensory perception of sour taste  protein homotrimerization  calcium ion transmembrane transport  cellular response to pH  
Ontology : EGO-EBIbehavioral fear response  response to amphetamine  protein binding  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  sodium ion transport  signal transduction  memory  associative learning  response to pH  cell surface  response to acidic pH  ligand-gated sodium channel activity  ion gated channel activity  ion transmembrane transport  sodium ion transmembrane transport  sodium ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  acid-sensing ion channel activity  acid-sensing ion channel activity  acid-sensing ion channel activity  synapse  negative regulation of neurotransmitter secretion  sensory perception of sour taste  protein homotrimerization  calcium ion transmembrane transport  cellular response to pH  
NDEx NetworkASIC1
Atlas of Cancer Signalling NetworkASIC1
Wikipedia pathwaysASIC1
Orthology - Evolution
OrthoDB41
GeneTree (enSembl)ENSG00000110881
Phylogenetic Trees/Animal Genes : TreeFamASIC1
HOGENOMP78348
Homologs : HomoloGeneASIC1
Homology/Alignments : Family Browser (UCSC)ASIC1
Gene fusions - Rearrangements
Fusion : QuiverASIC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerASIC1 [hg38]
dbVarASIC1
ClinVarASIC1
MonarchASIC1
1000_GenomesASIC1 
Exome Variant ServerASIC1
GNOMAD BrowserENSG00000110881
Varsome BrowserASIC1
Genomic Variants (DGV)ASIC1 [DGVbeta]
DECIPHERASIC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisASIC1 
Mutations
ICGC Data PortalASIC1 
TCGA Data PortalASIC1 
Broad Tumor PortalASIC1
OASIS PortalASIC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICASIC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DASIC1
Mutations and Diseases : HGMDASIC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ASIC1
DgiDB (Drug Gene Interaction Database)ASIC1
DoCM (Curated mutations)ASIC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ASIC1 (select a term)
intoGenASIC1
Cancer3DASIC1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602866   
Orphanet
DisGeNETASIC1
MedgenASIC1
Genetic Testing Registry ASIC1
NextProtP78348 [Medical]
GENETestsASIC1
Target ValidationASIC1
Huge Navigator ASIC1 [HugePedia]
ClinGenASIC1
Clinical trials, drugs, therapy
MyCancerGenomeASIC1
Protein Interactions : CTD
Pharm GKB GenePA24434
PharosP78348
Clinical trialASIC1
Miscellaneous
canSAR (ICR)ASIC1 (select the gene name)
HarmonizomeASIC1
DataMed IndexASIC1
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXASIC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:11:51 CET 2021
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