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ASIC1 (acid sensing ion channel subunit 1)

Identity

Alias_namesACCN2
amiloride-sensitive cation channel 2, neuronal
acid-sensing (proton-gated) ion channel 1
acid sensing (proton gated) ion channel 1
Alias_symbol (synonym)BNaC2
hBNaC2
Other aliasASIC
HGNC (Hugo) ASIC1
LocusID (NCBI) 41
Atlas_Id 47525
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 50057637 and ends at 50083622 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ASIC1   100
Cards
Entrez_Gene (NCBI)ASIC1  41  acid sensing ion channel subunit 1
AliasesACCN2; ASIC; BNaC2
GeneCards (Weizmann)ASIC1
Ensembl hg19 (Hinxton)ENSG00000110881 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110881 [Gene_View]  chr12:50057637-50083622 [Contig_View]  ASIC1 [Vega]
ICGC DataPortalENSG00000110881
TCGA cBioPortalASIC1
AceView (NCBI)ASIC1
Genatlas (Paris)ASIC1
WikiGenes41
SOURCE (Princeton)ASIC1
Genetics Home Reference (NIH)ASIC1
Genomic and cartography
GoldenPath hg38 (UCSC)ASIC1  -     chr12:50057637-50083622 +  12q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ASIC1  -     12q13.12   [Description]    (hg19-Feb_2009)
EnsemblASIC1 - 12q13.12 [CytoView hg19]  ASIC1 - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBIASIC1 [Mapview hg19]  ASIC1 [Mapview hg38]
OMIM602866   
Gene and transcription
Genbank (Entrez)AK290010 AK293960 AK311047 AW451342 BC013891
RefSeq transcript (Entrez)NM_001095 NM_001256830 NM_020039
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ASIC1
Cluster EST : UnigeneHs.274361 [ NCBI ]
CGAP (NCI)Hs.274361
Alternative Splicing GalleryENSG00000110881
Gene ExpressionASIC1 [ NCBI-GEO ]   ASIC1 [ EBI - ARRAY_EXPRESS ]   ASIC1 [ SEEK ]   ASIC1 [ MEM ]
Gene Expression Viewer (FireBrowse)ASIC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)41
GTEX Portal (Tissue expression)ASIC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78348   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78348  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78348
Splice isoforms : SwissVarP78348
PhosPhoSitePlusP78348
Domaine pattern : Prosite (Expaxy)ASC (PS01206)   
Domains : Interpro (EBI)ENaC    Na+channel_ASC    Na+channel_ASC_CS   
Domain families : Pfam (Sanger)ASC (PF00858)   
Domain families : Pfam (NCBI)pfam00858   
Conserved Domain (NCBI)ASIC1
DMDM Disease mutations41
Blocks (Seattle)ASIC1
SuperfamilyP78348
Human Protein AtlasENSG00000110881
Peptide AtlasP78348
HPRD04182
IPIIPI00293398   IPI00293399   IPI00796169   IPI01022600   IPI01022429   IPI00973761   
Protein Interaction databases
DIP (DOE-UCLA)P78348
IntAct (EBI)P78348
FunCoupENSG00000110881
BioGRIDASIC1
STRING (EMBL)ASIC1
ZODIACASIC1
Ontologies - Pathways
QuickGOP78348
Ontology : AmiGOprotein binding  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  transport  sodium ion transport  signal transduction  memory  associative learning  response to pH  cell surface  response to acidic pH  ligand-gated sodium channel activity  ion gated channel activity  ion transmembrane transport  sodium ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  acid-sensing ion channel activity  acid-sensing ion channel activity  acid-sensing ion channel activity  synapse  negative regulation of neurotransmitter secretion  sensory perception of sour taste  protein homotrimerization  calcium ion transmembrane transport  cellular response to pH  
Ontology : EGO-EBIprotein binding  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  transport  sodium ion transport  signal transduction  memory  associative learning  response to pH  cell surface  response to acidic pH  ligand-gated sodium channel activity  ion gated channel activity  ion transmembrane transport  sodium ion transmembrane transport  sodium ion transmembrane transport  regulation of membrane potential  acid-sensing ion channel activity  acid-sensing ion channel activity  acid-sensing ion channel activity  synapse  negative regulation of neurotransmitter secretion  sensory perception of sour taste  protein homotrimerization  calcium ion transmembrane transport  cellular response to pH  
NDEx NetworkASIC1
Atlas of Cancer Signalling NetworkASIC1
Wikipedia pathwaysASIC1
Orthology - Evolution
OrthoDB41
GeneTree (enSembl)ENSG00000110881
Phylogenetic Trees/Animal Genes : TreeFamASIC1
HOVERGENP78348
HOGENOMP78348
Homologs : HomoloGeneASIC1
Homology/Alignments : Family Browser (UCSC)ASIC1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerASIC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ASIC1
dbVarASIC1
ClinVarASIC1
1000_GenomesASIC1 
Exome Variant ServerASIC1
ExAC (Exome Aggregation Consortium)ASIC1 (select the gene name)
Genetic variants : HAPMAP41
Genomic Variants (DGV)ASIC1 [DGVbeta]
DECIPHERASIC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisASIC1 
Mutations
ICGC Data PortalASIC1 
TCGA Data PortalASIC1 
Broad Tumor PortalASIC1
OASIS PortalASIC1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDASIC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ASIC1
DgiDB (Drug Gene Interaction Database)ASIC1
DoCM (Curated mutations)ASIC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ASIC1 (select a term)
intoGenASIC1
Cancer3DASIC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602866   
Orphanet
MedgenASIC1
Genetic Testing Registry ASIC1
NextProtP78348 [Medical]
TSGene41
GENETestsASIC1
Target ValidationASIC1
Huge Navigator ASIC1 [HugePedia]
snp3D : Map Gene to Disease41
BioCentury BCIQASIC1
ClinGenASIC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD41
Chemical/Pharm GKB GenePA24434
Clinical trialASIC1
Miscellaneous
canSAR (ICR)ASIC1 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineASIC1
EVEXASIC1
GoPubMedASIC1
iHOPASIC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:47:23 CEST 2017

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