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ASIC2 (acid sensing ion channel subunit 2)

Identity

Alias_namesACCN
ACCN1
amiloride-sensitive cation channel 1, neuronal
acid-sensing (proton-gated) ion channel 2
Alias_symbol (synonym)ASIC2a
BNC1
BNaC1
hBNaC1
MDEG
Other alias
HGNC (Hugo) ASIC2
LocusID (NCBI) 40
Atlas_Id 551
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 31340106 and ends at 32483825 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ASIC2 (17q11.2) / PFDN2 (1q23.3)FIP1L1 (4q12) / ASIC2 (17q11.2)MYO1D (17q11.2) / ASIC2 (17q11.2)
NBPF1 (1p36.13) / ASIC2 (17q11.2)NF1 (17q11.2) / ASIC2 (17q11.2)TMIGD1 (17q11.2) / ASIC2 (17q11.2)
NF1 17q11.2 / ASIC2 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ASIC2   99
Cards
Entrez_Gene (NCBI)ASIC2  40  acid sensing ion channel subunit 2
AliasesACCN; ACCN1; ASIC2a; BNC1; 
BNaC1; MDEG; hBNaC1
GeneCards (Weizmann)ASIC2
Ensembl hg19 (Hinxton)ENSG00000108684 [Gene_View]  chr17:31340106-32483825 [Contig_View]  ASIC2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000108684 [Gene_View]  chr17:31340106-32483825 [Contig_View]  ASIC2 [Vega]
ICGC DataPortalENSG00000108684
TCGA cBioPortalASIC2
AceView (NCBI)ASIC2
Genatlas (Paris)ASIC2
WikiGenes40
SOURCE (Princeton)ASIC2
Genetics Home Reference (NIH)ASIC2
Genomic and cartography
GoldenPath hg19 (UCSC)ASIC2  -     chr17:31340106-32483825 -  17q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ASIC2  -     17q11.2   [Description]    (hg38-Dec_2013)
EnsemblASIC2 - 17q11.2 [CytoView hg19]  ASIC2 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBIASIC2 [Mapview hg19]  ASIC2 [Mapview hg38]
OMIM601784   
Gene and transcription
Genbank (Entrez)AK127748 AK313043 AL834182 BC075042 BC075043
RefSeq transcript (Entrez)NM_001094 NM_183377
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_029763 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)ASIC2
Cluster EST : UnigeneHs.368417 [ NCBI ]
CGAP (NCI)Hs.368417
Alternative Splicing GalleryENSG00000108684
Gene ExpressionASIC2 [ NCBI-GEO ]   ASIC2 [ EBI - ARRAY_EXPRESS ]   ASIC2 [ SEEK ]   ASIC2 [ MEM ]
Gene Expression Viewer (FireBrowse)ASIC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)40
GTEX Portal (Tissue expression)ASIC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16515   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16515  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16515
Splice isoforms : SwissVarQ16515
PhosPhoSitePlusQ16515
Domaine pattern : Prosite (Expaxy)ASC (PS01206)   
Domains : Interpro (EBI)ENaC    Na+channel_ASC    Na+channel_ASC_CS   
Domain families : Pfam (Sanger)ASC (PF00858)   
Domain families : Pfam (NCBI)pfam00858   
Conserved Domain (NCBI)ASIC2
DMDM Disease mutations40
Blocks (Seattle)ASIC2
SuperfamilyQ16515
Human Protein AtlasENSG00000108684
Peptide AtlasQ16515
HPRD03471
IPIIPI00002807   IPI00333823   
Protein Interaction databases
DIP (DOE-UCLA)Q16515
IntAct (EBI)Q16515
FunCoupENSG00000108684
BioGRIDASIC2
STRING (EMBL)ASIC2
ZODIACASIC2
Ontologies - Pathways
QuickGOQ16515
Ontology : AmiGOregulation of systemic arterial blood pressure by aortic arch baroreceptor feedback  protein binding  plasma membrane  integral component of plasma membrane  synaptic transmission  central nervous system development  peripheral nervous system development  phototransduction  sensory perception of sound  response to acidic pH  regulation of gene expression  ligand-gated sodium channel activity  monovalent inorganic cation transport  regulation of vasoconstriction  ion gated channel activity  regulation of blood coagulation  ion transmembrane transport  regulation of ion transmembrane transport  protein localization to synapse  sodium ion transmembrane transport  regulation of membrane potential  neuronal cell body  negative regulation of apoptotic process  dendritic spine  acid-sensing ion channel activity  sensory perception of sour taste  detection of mechanical stimulus involved in sensory perception  positive regulation of synapse assembly  
Ontology : EGO-EBIregulation of systemic arterial blood pressure by aortic arch baroreceptor feedback  protein binding  plasma membrane  integral component of plasma membrane  synaptic transmission  central nervous system development  peripheral nervous system development  phototransduction  sensory perception of sound  response to acidic pH  regulation of gene expression  ligand-gated sodium channel activity  monovalent inorganic cation transport  regulation of vasoconstriction  ion gated channel activity  regulation of blood coagulation  ion transmembrane transport  regulation of ion transmembrane transport  protein localization to synapse  sodium ion transmembrane transport  regulation of membrane potential  neuronal cell body  negative regulation of apoptotic process  dendritic spine  acid-sensing ion channel activity  sensory perception of sour taste  detection of mechanical stimulus involved in sensory perception  positive regulation of synapse assembly  
Pathways : KEGGTaste transduction   
NDEx NetworkASIC2
Atlas of Cancer Signalling NetworkASIC2
Wikipedia pathwaysASIC2
Orthology - Evolution
OrthoDB40
GeneTree (enSembl)ENSG00000108684
Phylogenetic Trees/Animal Genes : TreeFamASIC2
HOVERGENQ16515
HOGENOMQ16515
Homologs : HomoloGeneASIC2
Homology/Alignments : Family Browser (UCSC)ASIC2
Gene fusions - Rearrangements
Fusion : MitelmanASIC2/PFDN2 [17q11.2/1q23.3]  
Fusion : MitelmanMYO1D/ASIC2 [17q11.2/17q11.2]  [t(17;17)(q11;q12)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerASIC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ASIC2
dbVarASIC2
ClinVarASIC2
1000_GenomesASIC2 
Exome Variant ServerASIC2
ExAC (Exome Aggregation Consortium)ASIC2 (select the gene name)
Genetic variants : HAPMAP40
Genomic Variants (DGV)ASIC2 [DGVbeta]
DECIPHER (Syndromes)17:31340106-32483825  ENSG00000108684
CONAN: Copy Number AnalysisASIC2 
Mutations
ICGC Data PortalASIC2 
TCGA Data PortalASIC2 
Broad Tumor PortalASIC2
OASIS PortalASIC2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDASIC2
BioMutasearch ASIC2
DgiDB (Drug Gene Interaction Database)ASIC2
DoCM (Curated mutations)ASIC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ASIC2 (select a term)
intoGenASIC2
Cancer3DASIC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601784   
Orphanet
MedgenASIC2
Genetic Testing Registry ASIC2
NextProtQ16515 [Medical]
TSGene40
GENETestsASIC2
Huge Navigator ASIC2 [HugePedia]
snp3D : Map Gene to Disease40
BioCentury BCIQASIC2
ClinGenASIC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD40
Chemical/Pharm GKB GenePA24433
Clinical trialASIC2
Miscellaneous
canSAR (ICR)ASIC2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineASIC2
EVEXASIC2
GoPubMedASIC2
iHOPASIC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:53:13 CEST 2017

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