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ASL (argininosuccinate lyase)

Identity

Other namesASAL
HGNC (Hugo) ASL
LocusID (NCBI) 435
Location 7q11.21
Location_base_pair Starts at 65540776 and ends at 65558329 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)ASL   746
Cards
Entrez_Gene (NCBI)ASL  435  argininosuccinate lyase
GeneCards (Weizmann)ASL
Ensembl (Hinxton)ENSG00000126522 [Gene_View]  chr7:65540776-65558329 [Contig_View]  ASL [Vega]
ICGC DataPortalENSG00000126522
cBioPortalASL
AceView (NCBI)ASL
Genatlas (Paris)ASL
WikiGenes435
SOURCE (Princeton)NM_000048 NM_001024943 NM_001024944 NM_001024946
Genomic and cartography
GoldenPath (UCSC)ASL  -  7q11.21   chr7:65540776-65558329 +  7q11.21   [Description]    (hg19-Feb_2009)
EnsemblASL - 7q11.21 [CytoView]
Mapping of homologs : NCBIASL [Mapview]
OMIM207900   608310   
Gene and transcription
Genbank (Entrez)AI469765 AK300519 AK310912 AK316334 AY203938
RefSeq transcript (Entrez)NM_000048 NM_001024943 NM_001024944 NM_001024946
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_009288 NT_007933 NW_001839038 NW_004929332
Consensus coding sequences : CCDS (NCBI)ASL
Cluster EST : UnigeneHs.632015 [ NCBI ]
CGAP (NCI)Hs.632015
Alternative Splicing : Fast-db (Paris)GSHG0027402
Alternative Splicing GalleryENSG00000126522
Gene ExpressionASL [ NCBI-GEO ]     ASL [ SEEK ]   ASL [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04424 (Uniprot)
NextProtP04424  [Medical]
With graphics : InterProP04424
Splice isoforms : SwissVarP04424 (Swissvar)
Catalytic activity : Enzyme4.3.2.1 [ Enzyme-Expasy ]   4.3.2.14.3.2.1 [ IntEnz-EBI ]   4.3.2.1 [ BRENDA ]   4.3.2.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)FUMARATE_LYASES (PS00163)   
Domains : Interpro (EBI)Arg_succ_lyase_C [organisation]   Argininosuccinate_lyase [organisation]   Fumarase/histidase_N [organisation]   Fumarate_lyase_CS [organisation]   Fumarate_lyase_fam [organisation]   Fumarate_lyase_N [organisation]   L-Aspartase-like [organisation]  
Related proteins : CluSTrP04424
Domain families : Pfam (Sanger)ASL_C2 (PF14698)    Lyase_1 (PF00206)   
Domain families : Pfam (NCBI)pfam14698    pfam00206   
DMDM Disease mutations435
Blocks (Seattle)P04424
PDB (SRS)1AOS    1K62   
PDB (PDBSum)1AOS    1K62   
PDB (IMB)1AOS    1K62   
PDB (RSDB)1AOS    1K62   
Human Protein AtlasENSG00000126522 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP04424
HPRD01948
IPIIPI00220267   IPI01013158   IPI00607563   IPI00607562   IPI00926659   
Protein Interaction databases
DIP (DOE-UCLA)P04424
IntAct (EBI)P04424
FunCoupENSG00000126522
BioGRIDASL
InParanoidP04424
Interologous Interaction database P04424
IntegromeDBASL
STRING (EMBL)ASL
Ontologies - Pathways
Ontology : AmiGOurea cycle  urea cycle  argininosuccinate lyase activity  cytoplasm  cytosol  internal protein amino acid acetylation  arginine catabolic process  cellular nitrogen compound metabolic process  arginine biosynthetic process via ornithine  small molecule metabolic process  extracellular vesicular exosome  
Ontology : EGO-EBIurea cycle  urea cycle  argininosuccinate lyase activity  cytoplasm  cytosol  internal protein amino acid acetylation  arginine catabolic process  cellular nitrogen compound metabolic process  arginine biosynthetic process via ornithine  small molecule metabolic process  extracellular vesicular exosome  
Pathways : KEGGAlanine, aspartate and glutamate metabolism    Arginine and proline metabolism   
Protein Interaction DatabaseASL
Wikipedia pathwaysASL
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ASL
snp3D : Map Gene to Disease435
SNP (GeneSNP Utah)ASL
SNP : HGBaseASL
Genetic variants : HAPMAPASL
Exome VariantASL
1000_GenomesASL 
ICGC programENSG00000126522 
Somatic Mutations in Cancer : COSMICASL 
CONAN: Copy Number AnalysisASL 
Mutations and Diseases : HGMDASL
Genomic VariantsASL  ASL [DGVbeta]
dbVarASL
ClinVarASL
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM207900    608310   
MedgenASL
GENETestsASL
Disease Genetic AssociationASL
Huge Navigator ASL [HugePedia]  ASL [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneASL
Homology/Alignments : Family Browser (UCSC)ASL
Phylogenetic Trees/Animal Genes : TreeFamASL
Chemical/Protein Interactions : CTD435
Chemical/Pharm GKB GenePA25046
Clinical trialASL
Cancer Resource (Charite)ENSG00000126522
Other databases
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
CoreMineASL
iHOPASL
OncoSearchASL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:24:35 CEST 2014

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