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ASL (argininosuccinate lyase)

Identity

Other namesASAL
HGNC (Hugo) ASL
LocusID (NCBI) 435
Atlas_Id 52543
Location 7q11.21
Location_base_pair Starts at 65540776 and ends at 65558329 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ASL (7q11.21) / CRCP (7q11.21)ASL (7q11.21) / DIAPH1 (5q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ASL   746
Cards
Entrez_Gene (NCBI)ASL  435  argininosuccinate lyase
AliasesASAL
GeneCards (Weizmann)ASL
Ensembl hg19 (Hinxton)ENSG00000126522 [Gene_View]  chr7:65540776-65558329 [Contig_View]  ASL [Vega]
Ensembl hg38 (Hinxton)ENSG00000126522 [Gene_View]  chr7:65540776-65558329 [Contig_View]  ASL [Vega]
ICGC DataPortalENSG00000126522
TCGA cBioPortalASL
AceView (NCBI)ASL
Genatlas (Paris)ASL
WikiGenes435
SOURCE (Princeton)ASL
Genomic and cartography
GoldenPath hg19 (UCSC)ASL  -     chr7:65540776-65558329 +  7q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ASL  -     7q11.21   [Description]    (hg38-Dec_2013)
EnsemblASL - 7q11.21 [CytoView hg19]  ASL - 7q11.21 [CytoView hg38]
Mapping of homologs : NCBIASL [Mapview hg19]  ASL [Mapview hg38]
OMIM207900   608310   
Gene and transcription
Genbank (Entrez)AI469765 AK300519 AK310912 AK316334 AY203938
RefSeq transcript (Entrez)NM_000048 NM_001024943 NM_001024944 NM_001024946
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_009288 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)ASL
Cluster EST : UnigeneHs.632015 [ NCBI ]
CGAP (NCI)Hs.632015
Alternative Splicing GalleryENSG00000126522
Gene ExpressionASL [ NCBI-GEO ]   ASL [ EBI - ARRAY_EXPRESS ]   ASL [ SEEK ]   ASL [ MEM ]
Gene Expression Viewer (FireBrowse)ASL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)435
GTEX Portal (Tissue expression)ASL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04424 (Uniprot)
NextProtP04424  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04424
Splice isoforms : SwissVarP04424 (Swissvar)
Catalytic activity : Enzyme4.3.2.1 [ Enzyme-Expasy ]   4.3.2.14.3.2.1 [ IntEnz-EBI ]   4.3.2.1 [ BRENDA ]   4.3.2.1 [ KEGG ]   
PhosPhoSitePlusP04424
Domaine pattern : Prosite (Expaxy)FUMARATE_LYASES (PS00163)   
Domains : Interpro (EBI)Arg_succ_lyase_C    Argininosuccinate_lyase    Fumarase/histidase_N    Fumarate_lyase_CS    Fumarate_lyase_fam    Fumarate_lyase_N    L-Aspartase-like   
Domain families : Pfam (Sanger)ASL_C2 (PF14698)    Lyase_1 (PF00206)   
Domain families : Pfam (NCBI)pfam14698    pfam00206   
DMDM Disease mutations435
Blocks (Seattle)ASL
PDB (SRS)1AOS    1K62   
PDB (PDBSum)1AOS    1K62   
PDB (IMB)1AOS    1K62   
PDB (RSDB)1AOS    1K62   
Structural Biology KnowledgeBase1AOS    1K62   
SCOP (Structural Classification of Proteins)1AOS    1K62   
CATH (Classification of proteins structures)1AOS    1K62   
SuperfamilyP04424
Human Protein AtlasENSG00000126522
Peptide AtlasP04424
HPRD01948
IPIIPI00220267   IPI01013158   IPI00607563   IPI00607562   IPI00926659   
Protein Interaction databases
DIP (DOE-UCLA)P04424
IntAct (EBI)P04424
FunCoupENSG00000126522
BioGRIDASL
STRING (EMBL)ASL
ZODIACASL
Ontologies - Pathways
QuickGOP04424
Ontology : AmiGOurea cycle  urea cycle  urea cycle  argininosuccinate lyase activity  protein binding  cytoplasm  cytosol  cytosol  internal protein amino acid acetylation  arginine biosynthetic process  arginine catabolic process  arginine biosynthetic process via ornithine  protein tetramerization  extracellular exosome  
Ontology : EGO-EBIurea cycle  urea cycle  urea cycle  argininosuccinate lyase activity  protein binding  cytoplasm  cytosol  cytosol  internal protein amino acid acetylation  arginine biosynthetic process  arginine catabolic process  arginine biosynthetic process via ornithine  protein tetramerization  extracellular exosome  
Pathways : KEGGAlanine, aspartate and glutamate metabolism    Arginine and proline metabolism   
NDEx Network
Atlas of Cancer Signalling NetworkASL
Wikipedia pathwaysASL
Orthology - Evolution
OrthoDB435
GeneTree (enSembl)ENSG00000126522
Phylogenetic Trees/Animal Genes : TreeFamASL
Homologs : HomoloGeneASL
Homology/Alignments : Family Browser (UCSC)ASL
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerASL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ASL
dbVarASL
ClinVarASL
1000_GenomesASL 
Exome Variant ServerASL
ExAC (Exome Aggregation Consortium)ASL (select the gene name)
Genetic variants : HAPMAP435
Genomic Variants (DGV)ASL [DGVbeta]
Mutations
ICGC Data PortalASL 
TCGA Data PortalASL 
Broad Tumor PortalASL
OASIS PortalASL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICASL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ASL
DgiDB (Drug Gene Interaction Database)ASL
DoCM (Curated mutations)ASL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ASL (select a term)
intoGenASL
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:65540776-65558329  ENSG00000126522
CONAN: Copy Number AnalysisASL 
Mutations and Diseases : HGMDASL
OMIM207900    608310   
MedgenASL
Genetic Testing Registry ASL
NextProtP04424 [Medical]
TSGene435
GENETestsASL
Huge Navigator ASL [HugePedia]
snp3D : Map Gene to Disease435
BioCentury BCIQASL
ClinGenASL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD435
Chemical/Pharm GKB GenePA25046
Clinical trialASL
Miscellaneous
canSAR (ICR)ASL (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineASL
EVEXASL
GoPubMedASL
iHOPASL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 10:54:37 CEST 2016

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