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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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ASL (argininosuccinate lyase)

Identity

Other namesASAL
HGNC (Hugo) ASL
LocusID (NCBI) 435
Location 7q11.21
Location_base_pair Starts at 65540776 and ends at 65558329 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)ASL   746
Cards
Entrez_Gene (NCBI)ASL  435  argininosuccinate lyase
GeneCards (Weizmann)ASL
Ensembl hg19 (Hinxton)ENSG00000126522 [Gene_View]  chr7:65540776-65558329 [Contig_View]  ASL [Vega]
Ensembl hg38 (Hinxton)ENSG00000126522 [Gene_View]  chr7:65540776-65558329 [Contig_View]  ASL [Vega]
ICGC DataPortalENSG00000126522
cBioPortalASL
AceView (NCBI)ASL
Genatlas (Paris)ASL
WikiGenes435
SOURCE (Princeton)ASL
Genomic and cartography
GoldenPath hg19 (UCSC)ASL  -     chr7:65540776-65558329 +  7q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ASL  -     7q11.21   [Description]    (hg38-Dec_2013)
EnsemblASL - 7q11.21 [CytoView hg19]  ASL - 7q11.21 [CytoView hg38]
Mapping of homologs : NCBIASL [Mapview hg19]  ASL [Mapview hg38]
OMIM207900   608310   
Gene and transcription
Genbank (Entrez)AI469765 AK300519 AK310912 AK316334 AY203938
RefSeq transcript (Entrez)NM_000048 NM_001024943 NM_001024944 NM_001024946
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_009288 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)ASL
Cluster EST : UnigeneHs.632015 [ NCBI ]
CGAP (NCI)Hs.632015
Alternative Splicing : Fast-db (Paris)GSHG0027402
Alternative Splicing GalleryENSG00000126522
Gene ExpressionASL [ NCBI-GEO ]     ASL [ SEEK ]   ASL [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04424 (Uniprot)
NextProtP04424  [Medical]
With graphics : InterProP04424
Splice isoforms : SwissVarP04424 (Swissvar)
Catalytic activity : Enzyme4.3.2.1 [ Enzyme-Expasy ]   4.3.2.14.3.2.1 [ IntEnz-EBI ]   4.3.2.1 [ BRENDA ]   4.3.2.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)FUMARATE_LYASES (PS00163)   
Domains : Interpro (EBI)Arg_succ_lyase_C    Argininosuccinate_lyase    Fumarase/histidase_N    Fumarate_lyase_CS    Fumarate_lyase_fam    Fumarate_lyase_N    L-Aspartase-like   
Related proteins : CluSTrP04424
Domain families : Pfam (Sanger)ASL_C2 (PF14698)    Lyase_1 (PF00206)   
Domain families : Pfam (NCBI)pfam14698    pfam00206   
DMDM Disease mutations435
Blocks (Seattle)P04424
PDB (SRS)1AOS    1K62   
PDB (PDBSum)1AOS    1K62   
PDB (IMB)1AOS    1K62   
PDB (RSDB)1AOS    1K62   
Human Protein AtlasENSG00000126522
Peptide AtlasP04424
HPRD01948
IPIIPI00220267   IPI01013158   IPI00607563   IPI00607562   IPI00926659   
Protein Interaction databases
DIP (DOE-UCLA)P04424
IntAct (EBI)P04424
FunCoupENSG00000126522
BioGRIDASL
IntegromeDBASL
STRING (EMBL)ASL
Ontologies - Pathways
QuickGOP04424
Ontology : AmiGOurea cycle  urea cycle  argininosuccinate lyase activity  protein binding  cytoplasm  cytosol  internal protein amino acid acetylation  arginine catabolic process  cellular nitrogen compound metabolic process  arginine biosynthetic process via ornithine  small molecule metabolic process  extracellular exosome  
Ontology : EGO-EBIurea cycle  urea cycle  argininosuccinate lyase activity  protein binding  cytoplasm  cytosol  internal protein amino acid acetylation  arginine catabolic process  cellular nitrogen compound metabolic process  arginine biosynthetic process via ornithine  small molecule metabolic process  extracellular exosome  
Pathways : KEGGAlanine, aspartate and glutamate metabolism    Arginine and proline metabolism   
Protein Interaction DatabaseASL
DoCM (Curated mutations)ASL
Wikipedia pathwaysASL
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerASL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ASL
dbVarASL
ClinVarASL
1000_GenomesASL 
Exome Variant ServerASL
SNP (GeneSNP Utah)ASL
SNP : HGBaseASL
Genetic variants : HAPMAPASL
Genomic Variants (DGV)ASL [DGVbeta]
Mutations
ICGC Data PortalENSG00000126522 
Somatic Mutations in Cancer : COSMICASL 
CONAN: Copy Number AnalysisASL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:65540776-65558329
Mutations and Diseases : HGMDASL
OMIM207900    608310   
MedgenASL
NextProtP04424 [Medical]
GENETestsASL
Disease Genetic AssociationASL
Huge Navigator ASL [HugePedia]  ASL [HugeCancerGEM]
snp3D : Map Gene to Disease435
DGIdb (Drug Gene Interaction db)ASL
General knowledge
Homologs : HomoloGeneASL
Homology/Alignments : Family Browser (UCSC)ASL
Phylogenetic Trees/Animal Genes : TreeFamASL
Chemical/Protein Interactions : CTD435
Chemical/Pharm GKB GenePA25046
Clinical trialASL
Cancer Resource (Charite)ENSG00000126522
Other databases
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
CoreMineASL
GoPubMedASL
iHOPASL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 14:46:25 CET 2015

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