ASPN (asporin)

2010-02-01  

Identity

HGNC
ASPN
LOCATION
9q22.31
LOCUSID
54829
ALIAS
OS3,PLAP-1,PLAP1,SLRR1C

Other Information

Locus ID:

NCBI: 54829
MIM: 608135
HGNC: 14872
Ensembl: ENSG00000106819

Variants:

dbSNP: 54829
ClinVar: 54829
TCGA: ENSG00000106819
COSMIC: ASPN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106819ENST00000375543Q5TBF2
ENSG00000106819ENST00000375544Q9BXN1
ENSG00000106819ENST00000650794A0A494C1J0
ENSG00000106819ENST00000651738A0A494C084

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
ECM proteoglycansREACTOMER-HSA-3000178

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
156408002005An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.129
171952162007Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee.53
178271582007Mechanisms for asporin function and regulation in articular cartilage.51
195891272009Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization.39
183044942008Association of the asporin D14 allele with lumbar-disc degeneration in Asians.33
183044942008Association of the asporin D14 allele with lumbar-disc degeneration in Asians.33
244410392015Asporin activates coordinated invasion of scirrhous gastric cancer and cancer-associated fibroblasts.29
170243132006Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese.25
170243132006Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese.25
175176962007Meta-analysis of association between the ASPN D-repeat and osteoarthritis.25

Citation

Dessen P

ASPN (asporin)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51344/aspn