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ASRGL1 (asparaginase and isoaspartyl peptidase 1)

Identity

Alias_namesasparaginase like 1
Alias_symbol (synonym)FLJ22316
ALP1
ALP
Other aliasCRASH
HGNC (Hugo) ASRGL1
LocusID (NCBI) 80150
Atlas_Id 51011
Location 11q12.3  [Link to chromosome band 11q12]
Location_base_pair Starts at 62337302 and ends at 62393415 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASRGL1 (11q12.3) / ASRGL1 (11q12.3)ASRGL1 (11q12.3) / ASTN1 (1q25.2)ASRGL1 (11q12.3) / MYBL2 (20q13.12)
ATP2B4 (1q32.1) / ASRGL1 (11q12.3)NUCKS1 (1q32.1) / ASRGL1 (11q12.3)PFKFB3 (10p15.1) / ASRGL1 (11q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ASRGL1   16448
Cards
Entrez_Gene (NCBI)ASRGL1  80150  asparaginase and isoaspartyl peptidase 1
AliasesALP; ALP1; CRASH
GeneCards (Weizmann)ASRGL1
Ensembl hg19 (Hinxton)ENSG00000162174 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162174 [Gene_View]  ENSG00000162174 [Sequence]  chr11:62337302-62393415 [Contig_View]  ASRGL1 [Vega]
ICGC DataPortalENSG00000162174
TCGA cBioPortalASRGL1
AceView (NCBI)ASRGL1
Genatlas (Paris)ASRGL1
WikiGenes80150
SOURCE (Princeton)ASRGL1
Genetics Home Reference (NIH)ASRGL1
Genomic and cartography
GoldenPath hg38 (UCSC)ASRGL1  -     chr11:62337302-62393415 +  11q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ASRGL1  -     11q12.3   [Description]    (hg19-Feb_2009)
GoldenPathASRGL1 - 11q12.3 [CytoView hg19]  ASRGL1 - 11q12.3 [CytoView hg38]
ImmunoBaseENSG00000162174
Mapping of homologs : NCBIASRGL1 [Mapview hg19]  ASRGL1 [Mapview hg38]
OMIM609212   
Gene and transcription
Genbank (Entrez)AF411076 AK090908 AK091894 AK225802 AK297158
RefSeq transcript (Entrez)NM_001083926 NM_025080
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ASRGL1
Alternative Splicing GalleryENSG00000162174
Gene ExpressionASRGL1 [ NCBI-GEO ]   ASRGL1 [ EBI - ARRAY_EXPRESS ]   ASRGL1 [ SEEK ]   ASRGL1 [ MEM ]
Gene Expression Viewer (FireBrowse)ASRGL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80150
GTEX Portal (Tissue expression)ASRGL1
Human Protein AtlasENSG00000162174-ASRGL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L266   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L266  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L266
Splice isoforms : SwissVarQ7L266
PhosPhoSitePlusQ7L266
Domains : Interpro (EBI)ASRGL1_meta    Ntn_hydrolases_N    Peptidase_T2   
Domain families : Pfam (Sanger)Asparaginase_2 (PF01112)   
Domain families : Pfam (NCBI)pfam01112   
Conserved Domain (NCBI)ASRGL1
DMDM Disease mutations80150
Blocks (Seattle)ASRGL1
PDB (RSDB)3TKJ    4ET0    4O0C    4O0D    4O0E    4O0F    4O0G    4O0H    4OSX    4OSY    4PVP    4PVQ    4PVR    4PVS    4ZM9   
PDB Europe3TKJ    4ET0    4O0C    4O0D    4O0E    4O0F    4O0G    4O0H    4OSX    4OSY    4PVP    4PVQ    4PVR    4PVS    4ZM9   
PDB (PDBSum)3TKJ    4ET0    4O0C    4O0D    4O0E    4O0F    4O0G    4O0H    4OSX    4OSY    4PVP    4PVQ    4PVR    4PVS    4ZM9   
PDB (IMB)3TKJ    4ET0    4O0C    4O0D    4O0E    4O0F    4O0G    4O0H    4OSX    4OSY    4PVP    4PVQ    4PVR    4PVS    4ZM9   
Structural Biology KnowledgeBase3TKJ    4ET0    4O0C    4O0D    4O0E    4O0F    4O0G    4O0H    4OSX    4OSY    4PVP    4PVQ    4PVR    4PVS    4ZM9   
SCOP (Structural Classification of Proteins)3TKJ    4ET0    4O0C    4O0D    4O0E    4O0F    4O0G    4O0H    4OSX    4OSY    4PVP    4PVQ    4PVR    4PVS    4ZM9   
CATH (Classification of proteins structures)3TKJ    4ET0    4O0C    4O0D    4O0E    4O0F    4O0G    4O0H    4OSX    4OSY    4PVP    4PVQ    4PVR    4PVS    4ZM9   
SuperfamilyQ7L266
Human Protein Atlas [tissue]ENSG00000162174-ASRGL1 [tissue]
Peptide AtlasQ7L266
HPRD07006
IPIIPI00555734   IPI00867663   IPI00908499   IPI00977423   
Protein Interaction databases
DIP (DOE-UCLA)Q7L266
IntAct (EBI)Q7L266
FunCoupENSG00000162174
BioGRIDASRGL1
STRING (EMBL)ASRGL1
ZODIACASRGL1
Ontologies - Pathways
QuickGOQ7L266
Ontology : AmiGOphotoreceptor inner segment  N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity  asparaginase activity  asparaginase activity  asparaginase activity  nucleus  cytoplasm  cytoplasm  cytoplasm  cytosol  proteolysis  L-phenylalanine catabolic process  beta-aspartyl-peptidase activity  beta-aspartyl-peptidase activity  asparagine catabolic process via L-aspartate  asparagine catabolic process via L-aspartate  asparagine catabolic process via L-aspartate  
Ontology : EGO-EBIphotoreceptor inner segment  N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity  asparaginase activity  asparaginase activity  asparaginase activity  nucleus  cytoplasm  cytoplasm  cytoplasm  cytosol  proteolysis  L-phenylalanine catabolic process  beta-aspartyl-peptidase activity  beta-aspartyl-peptidase activity  asparagine catabolic process via L-aspartate  asparagine catabolic process via L-aspartate  asparagine catabolic process via L-aspartate  
NDEx NetworkASRGL1
Atlas of Cancer Signalling NetworkASRGL1
Wikipedia pathwaysASRGL1
Orthology - Evolution
OrthoDB80150
GeneTree (enSembl)ENSG00000162174
Phylogenetic Trees/Animal Genes : TreeFamASRGL1
HOGENOMQ7L266
Homologs : HomoloGeneASRGL1
Homology/Alignments : Family Browser (UCSC)ASRGL1
Gene fusions - Rearrangements
Fusion : QuiverASRGL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerASRGL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ASRGL1
dbVarASRGL1
ClinVarASRGL1
1000_GenomesASRGL1 
Exome Variant ServerASRGL1
ExAC (Exome Aggregation Consortium)ENSG00000162174
GNOMAD BrowserENSG00000162174
Varsome BrowserASRGL1
Genetic variants : HAPMAP80150
Genomic Variants (DGV)ASRGL1 [DGVbeta]
DECIPHERASRGL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisASRGL1 
Mutations
ICGC Data PortalASRGL1 
TCGA Data PortalASRGL1 
Broad Tumor PortalASRGL1
OASIS PortalASRGL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICASRGL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DASRGL1
Mutations and Diseases : HGMDASRGL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ASRGL1
DgiDB (Drug Gene Interaction Database)ASRGL1
DoCM (Curated mutations)ASRGL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ASRGL1 (select a term)
intoGenASRGL1
Cancer3DASRGL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609212   
Orphanet
DisGeNETASRGL1
MedgenASRGL1
Genetic Testing Registry ASRGL1
NextProtQ7L266 [Medical]
TSGene80150
GENETestsASRGL1
Target ValidationASRGL1
Huge Navigator ASRGL1 [HugePedia]
snp3D : Map Gene to Disease80150
BioCentury BCIQASRGL1
ClinGenASRGL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80150
Chemical/Pharm GKB GenePA25059
Clinical trialASRGL1
Miscellaneous
canSAR (ICR)ASRGL1 (select the gene name)
HarmonizomeASRGL1
DataMed IndexASRGL1
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineASRGL1
EVEXASRGL1
GoPubMedASRGL1
iHOPASRGL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 10 12:07:30 CEST 2020
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