ATAD3B (ATPase family AAA domain containing 3B)

2012-03-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
AAA-TOB3,TOB3
FUSION GENES

Other Information

Locus ID:

NCBI: 83858
MIM: 612317
HGNC: 24007
Ensembl: ENSG00000160072

Variants:

dbSNP: 83858
ClinVar: 83858
TCGA: ENSG00000160072
COSMIC: ATAD3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160072ENST00000308647Q5T9A4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
172109502007The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.76
285491282017ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
186395452008ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties.15
226647262012ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A.11
242395512014Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues.5
238188392013Integrative analysis of deep sequencing data identifies estrogen receptor early response genes and links ATAD3B to poor survival in breast cancer.4
286236442017Increased AAA-TOB3 correlates with lymph node metastasis and advanced stage of lung adenocarcinoma.1
221927482011[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].0

Citation

Dessen P

ATAD3B (ATPase family AAA domain containing 3B)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52623/atad3b