| ATF6 (1q23.3) / GJA5 (1q21.2) | ATF6 (1q23.3) / PCP4L1 (1q23.3) | ATF6 (1q23.3) / SH2D1B (1q23.3) |
|
ATP6V0A1 (17q21.2) / ATF6 (1q23.3) | CTBP1 (4p16.3) / ATF6 (1q23.3) | MAGI3 (1p13.2) / ATF6 (1q23.3) |
|
NMNAT2 (1q25.3) / ATF6 (1q23.3) | NOS1AP (1q23.3) / ATF6 (1q23.3) | PMEPA1 (20q13.31) / ATF6 (1q23.3) |
|
ZNF318 (6p21.1) / ATF6 (1q23.3) | ATF6 1q23.3 / GJA5 1q21.2 | ATF6 1q23.3 / PCP4L1 1q23.3 |
|
ATF6 1q23.3 / SH2D1B 1q23.3 | ATP6V0A1 17q21.2 / ATF6 1q23.3 | MAGI3 1p13.2 / ATF6 1q23.3 |
|
NMNAT2 1q25.3 / ATF6 1q23.3 | NOS1AP 1q23.3 / ATF6 1q23.3 |
| Nomenclature |
HGNC (Hugo) | ATF6 791 |
| Cards |
Entrez_Gene (NCBI) | ATF6 activating transcription factor 6 |
Aliases | ACHM7; ATF6A |
GeneCards (Weizmann) | ATF6 |
Ensembl hg19 (Hinxton) | ENSG00000118217 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000118217 [Gene_View]  ENSG00000118217 [Sequence] chr1:161766320-161964070 [Contig_View] ATF6 [Vega] |
ICGC DataPortal | ENSG00000118217 |
TCGA cBioPortal | ATF6 |
AceView (NCBI) | ATF6 |
Genatlas (Paris) | ATF6 |
SOURCE (Princeton) | ATF6 |
Genetics Home Reference (NIH) | ATF6 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | ATF6 - chr1:161766320-161964070 + 1q23.3 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | ATF6 - 1q23.3 [Description] (hg19-Feb_2009) |
GoldenPath | ATF6 - 1q23.3 [CytoView hg19] ATF6 - 1q23.3 [CytoView hg38] |
ImmunoBase | ENSG00000118217 |
genome Data Viewer NCBI | ATF6 [Mapview hg19] |
OMIM | 605537 616517 |
| Gene and transcription |
Genbank (Entrez) | AB015856 AB208929 AF005887 AF088035 AK025316 |
RefSeq transcript (Entrez) | NM_007348 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | ATF6 |
Alternative Splicing Gallery | ENSG00000118217 |
Gene Expression | ATF6 [ NCBI-GEO ] ATF6 [ EBI - ARRAY_EXPRESS ]
ATF6 [ SEEK ] ATF6 [ MEM ] |
Gene Expression Viewer (FireBrowse) | ATF6 [ Firebrowse - Broad ] |
Genevisible | Expression of ATF6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 22926 |
GTEX Portal (Tissue expression) | ATF6 |
Human Protein Atlas | ENSG00000118217-ATF6 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P18850 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P18850 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P18850 |
Splice isoforms : SwissVar | P18850 |
PhosPhoSitePlus | P18850 |
Domaine pattern : Prosite (Expaxy) | BZIP (PS50217) BZIP_BASIC (PS00036) |
Domains : Interpro (EBI) | ATF6A bZIP |
Domain families : Pfam (Sanger) | bZIP_1 (PF00170) |
Domain families : Pfam (NCBI) | pfam00170 |
Domain families : Smart (EMBL) | BRLZ (SM00338) |
Conserved Domain (NCBI) | ATF6 |
Blocks (Seattle) | ATF6 |
Superfamily | P18850 |
Human Protein Atlas [tissue] | ENSG00000118217-ATF6 [tissue] |
Peptide Atlas | P18850 |
HPRD | 16118 |
IPI | IPI00002511 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P18850 |
IntAct (EBI) | P18850 |
BioGRID | ATF6 |
STRING (EMBL) | ATF6 |
ZODIAC | ATF6 |
| Ontologies - Pathways |
QuickGO | P18850 |
Ontology : AmiGO | Golgi membrane nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific eye development DNA-binding transcription factor activity transcription coactivator activity protein binding nucleus nuclear envelope nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol regulation of transcription by RNA polymerase II protein folding signal transduction visual perception membrane integral component of endoplasmic reticulum membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response ubiquitin protein ligase binding cAMP response element binding ATF6-mediated unfolded protein response identical protein binding positive regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription by RNA polymerase II protein heterodimerization activity positive regulation of ATF6-mediated unfolded protein response positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
Ontology : EGO-EBI | Golgi membrane nuclear chromatin transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific eye development DNA-binding transcription factor activity transcription coactivator activity protein binding nucleus nuclear envelope nucleoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus cytosol regulation of transcription by RNA polymerase II protein folding signal transduction visual perception membrane integral component of endoplasmic reticulum membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response ubiquitin protein ligase binding cAMP response element binding ATF6-mediated unfolded protein response identical protein binding positive regulation of apoptotic process sequence-specific DNA binding positive regulation of transcription by RNA polymerase II protein heterodimerization activity positive regulation of ATF6-mediated unfolded protein response positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
Pathways : KEGG | Protein processing in endoplasmic reticulum Alzheimer's disease |
NDEx Network | ATF6 |
Atlas of Cancer Signalling Network | ATF6 |
Wikipedia pathways | ATF6 |
| Orthology - Evolution |
OrthoDB | 22926 |
GeneTree (enSembl) | ENSG00000118217 |
Phylogenetic Trees/Animal Genes : TreeFam | ATF6 |
HOGENOM | P18850 |
Homologs : HomoloGene | ATF6 |
Homology/Alignments : Family Browser (UCSC) | ATF6 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | ATF6/GJA5 [1q23.3/1q21.2]   |
Fusion : Mitelman | ATF6/PCP4L1 [1q23.3/1q23.3]   |
Fusion : Mitelman | ATF6/SH2D1B [1q23.3/1q23.3]   |
Fusion : Mitelman | ATP6V0A1/ATF6 [17q21.2/1q23.3]   |
Fusion : Mitelman | MAGI3/ATF6 [1p13.2/1q23.3]   |
Fusion : Mitelman | NMNAT2/ATF6 [1q25.3/1q23.3]   |
Fusion : Mitelman | NOS1AP/ATF6 [1q23.3/1q23.3]   |
Fusion Portal | ATF6 1q23.3 GJA5 1q21.2 LUAD |
Fusion Portal | ATF6 1q23.3 PCP4L1 1q23.3 LUAD |
Fusion Portal | ATF6 1q23.3 SH2D1B 1q23.3 BRCA |
Fusion Portal | ATP6V0A1 17q21.2 ATF6 1q23.3 BRCA |
Fusion Portal | MAGI3 1p13.2 ATF6 1q23.3 BRCA |
Fusion Portal | NMNAT2 1q25.3 ATF6 1q23.3 LGG |
Fusion Portal | NOS1AP 1q23.3 ATF6 1q23.3 LUAD |
Fusion : Quiver | ATF6 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | ATF6 [hg38] |
dbVar | ATF6 |
ClinVar | ATF6 |
Monarch | ATF6 |
1000_Genomes | ATF6 |
Exome Variant Server | ATF6 |
GNOMAD Browser | ENSG00000118217 |
Varsome Browser | ATF6 |
Genomic Variants (DGV) | ATF6 [DGVbeta] |
DECIPHER | ATF6 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | ATF6 |
| Mutations |
ICGC Data Portal | ATF6 |
TCGA Data Portal | ATF6 |
Broad Tumor Portal | ATF6 |
OASIS Portal | ATF6 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | ATF6 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | ATF6 |
Mutations and Diseases : HGMD | ATF6 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search ATF6 |
DgiDB (Drug Gene Interaction Database) | ATF6 |
DoCM (Curated mutations) | ATF6 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | ATF6 (select a term) |
intoGen | ATF6 |
Cancer3D | ATF6(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 605537 616517 |
Orphanet | 10639 |
DisGeNET | ATF6 |
Medgen | ATF6 |
Genetic Testing Registry | ATF6
|
NextProt | P18850 [Medical] |
GENETests | ATF6 |
Target Validation | ATF6 |
Huge Navigator |
ATF6 [HugePedia] |
ClinGen | ATF6 |
| Clinical trials, drugs, therapy |
---|
MyCancerGenome | ATF6 |
Protein Interactions : CTD | |
Pharm GKB Gene | PA25091 |
Pharos | P18850 |
Clinical trial | ATF6 |
| Miscellaneous |
---|
canSAR (ICR) | ATF6 (select the gene name) |
Harmonizome | ATF6 |
DataMed Index | ATF6 |
| Probes |
---|
| Litterature |
---|
PubMed | 174 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | ATF6 |