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ATF7IP (activating transcription factor 7 interacting protein)

Identity

Alias_symbol (synonym)FLJ10688
p621
Other aliasAM
ATF-IP
MCAF
MCAF1
HGNC (Hugo) ATF7IP
LocusID (NCBI) 55729
Atlas_Id 51647
Location 12p13.1  [Link to chromosome band 12p13]
Location_base_pair Starts at 14365632 and ends at 14502935 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATF7IP (12p13.1) / ASAP3 (1p36.12)ATF7IP (12p13.1) / ATF7IP (12p13.1)ATF7IP (12p13.1) / ATP6V0E1 (5q35.1)
ATF7IP (12p13.1) / MALAT1 (11q13.1)ATF7IP (12p13.1) / PDGFRB (5q32)ATF7IP (12p13.1) / TMPRSS2 (21q22.3)
ATF7IP (12p13.1) / ZIM2 (19q13.43)COL16A1 (1p35.2) / ATF7IP (12p13.1)TBC1D15 (12q21.1) / ATF7IP (12p13.1)
TMPRSS2 (21q22.3) / ATF7IP (12p13.1)ATF7IP 12p13.1 / TMPRSS2 21q22.3COL16A1 1p35.2 / ATF7IP 12p13.1
TMPRSS2 21q22.3 / ATF7IP 12p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;12)(q33;p13) ATF7IP/PDGFRB


External links

Nomenclature
HGNC (Hugo)ATF7IP   20092
Cards
Entrez_Gene (NCBI)ATF7IP  55729  activating transcription factor 7 interacting protein
AliasesAM; ATF-IP; MCAF; MCAF1; 
p621
GeneCards (Weizmann)ATF7IP
Ensembl hg19 (Hinxton)ENSG00000171681 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171681 [Gene_View]  chr12:14365632-14502935 [Contig_View]  ATF7IP [Vega]
ICGC DataPortalENSG00000171681
TCGA cBioPortalATF7IP
AceView (NCBI)ATF7IP
Genatlas (Paris)ATF7IP
WikiGenes55729
SOURCE (Princeton)ATF7IP
Genetics Home Reference (NIH)ATF7IP
Genomic and cartography
GoldenPath hg38 (UCSC)ATF7IP  -     chr12:14365632-14502935 +  12p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ATF7IP  -     12p13.1   [Description]    (hg19-Feb_2009)
EnsemblATF7IP - 12p13.1 [CytoView hg19]  ATF7IP - 12p13.1 [CytoView hg38]
Mapping of homologs : NCBIATF7IP [Mapview hg19]  ATF7IP [Mapview hg38]
OMIM613644   
Gene and transcription
Genbank (Entrez)AF425650 AJ242978 AK001001 AK001550 AK025060
RefSeq transcript (Entrez)NM_001286514 NM_001286515 NM_018179 NM_181352
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ATF7IP
Cluster EST : UnigeneHs.591151 [ NCBI ]
CGAP (NCI)Hs.591151
Alternative Splicing GalleryENSG00000171681
Gene ExpressionATF7IP [ NCBI-GEO ]   ATF7IP [ EBI - ARRAY_EXPRESS ]   ATF7IP [ SEEK ]   ATF7IP [ MEM ]
Gene Expression Viewer (FireBrowse)ATF7IP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55729
GTEX Portal (Tissue expression)ATF7IP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6VMQ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6VMQ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6VMQ6
Splice isoforms : SwissVarQ6VMQ6
PhosPhoSitePlusQ6VMQ6
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)ATF7-int    ATF7IP_BD    FN3_dom    Ig-like_fold   
Domain families : Pfam (Sanger)ATF7IP_BD (PF16788)    fn3_4 (PF16794)   
Domain families : Pfam (NCBI)pfam16788    pfam16794   
Conserved Domain (NCBI)ATF7IP
DMDM Disease mutations55729
Blocks (Seattle)ATF7IP
PDB (SRS)2RPQ   
PDB (PDBSum)2RPQ   
PDB (IMB)2RPQ   
PDB (RSDB)2RPQ   
Structural Biology KnowledgeBase2RPQ   
SCOP (Structural Classification of Proteins)2RPQ   
CATH (Classification of proteins structures)2RPQ   
SuperfamilyQ6VMQ6
Human Protein AtlasENSG00000171681
Peptide AtlasQ6VMQ6
HPRD09811
IPIIPI00795654   IPI00796928   IPI01010907   IPI00794198   IPI01011394   IPI01009475   IPI01010546   IPI01009981   IPI01009514   IPI01015891   IPI01014636   IPI01015134   IPI00796299   IPI01014092   IPI01013264   IPI01012844   IPI00942816   IPI01011403   
Protein Interaction databases
DIP (DOE-UCLA)Q6VMQ6
IntAct (EBI)Q6VMQ6
FunCoupENSG00000171681
BioGRIDATF7IP
STRING (EMBL)ATF7IP
ZODIACATF7IP
Ontologies - Pathways
QuickGOQ6VMQ6
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytosol  DNA methylation  transcription, DNA-templated  viral process  nuclear body  ATPase activity  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  regulation of RNA polymerase II transcriptional preinitiation complex assembly  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcription corepressor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytosol  DNA methylation  transcription, DNA-templated  viral process  nuclear body  ATPase activity  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  regulation of RNA polymerase II transcriptional preinitiation complex assembly  
NDEx NetworkATF7IP
Atlas of Cancer Signalling NetworkATF7IP
Wikipedia pathwaysATF7IP
Orthology - Evolution
OrthoDB55729
GeneTree (enSembl)ENSG00000171681
Phylogenetic Trees/Animal Genes : TreeFamATF7IP
HOVERGENQ6VMQ6
HOGENOMQ6VMQ6
Homologs : HomoloGeneATF7IP
Homology/Alignments : Family Browser (UCSC)ATF7IP
Gene fusions - Rearrangements
Fusion : MitelmanATF7IP/PDGFRB [12p13.1/5q32]  
Fusion : MitelmanATF7IP/TMPRSS2 [12p13.1/21q22.3]  [t(12;21)(p13;q22)]  
Fusion : MitelmanCOL16A1/ATF7IP [1p35.2/12p13.1]  [t(1;12)(p35;p13)]  
Fusion : MitelmanTMPRSS2/ATF7IP [21q22.3/12p13.1]  [t(12;21)(p13;q22)]  
Fusion: TCGAATF7IP 12p13.1 TMPRSS2 21q22.3 PRAD
Fusion: TCGACOL16A1 1p35.2 ATF7IP 12p13.1 BRCA
Fusion: TCGATMPRSS2 21q22.3 ATF7IP 12p13.1 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATF7IP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATF7IP
dbVarATF7IP
ClinVarATF7IP
1000_GenomesATF7IP 
Exome Variant ServerATF7IP
ExAC (Exome Aggregation Consortium)ATF7IP (select the gene name)
Genetic variants : HAPMAP55729
Genomic Variants (DGV)ATF7IP [DGVbeta]
DECIPHERATF7IP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisATF7IP 
Mutations
ICGC Data PortalATF7IP 
TCGA Data PortalATF7IP 
Broad Tumor PortalATF7IP
OASIS PortalATF7IP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATF7IP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDATF7IP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATF7IP
DgiDB (Drug Gene Interaction Database)ATF7IP
DoCM (Curated mutations)ATF7IP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATF7IP (select a term)
intoGenATF7IP
Cancer3DATF7IP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613644   
Orphanet
MedgenATF7IP
Genetic Testing Registry ATF7IP
NextProtQ6VMQ6 [Medical]
TSGene55729
GENETestsATF7IP
Huge Navigator ATF7IP [HugePedia]
snp3D : Map Gene to Disease55729
BioCentury BCIQATF7IP
ClinGenATF7IP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55729
Chemical/Pharm GKB GenePA134889460
Clinical trialATF7IP
Miscellaneous
canSAR (ICR)ATF7IP (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATF7IP
EVEXATF7IP
GoPubMedATF7IP
iHOPATF7IP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:07:00 CEST 2017

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