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ATF7IP (activating transcription factor 7 interacting protein)

Identity

Alias (NCBI)AM
ATF-IP
MCAF
MCAF1
p621
HGNC (Hugo) ATF7IP
HGNC Alias symbFLJ10688
p621
LocusID (NCBI) 55729
Atlas_Id 51647
Location 12p13.1  [Link to chromosome band 12p13]
Location_base_pair Starts at 14385281 and ends at 14502930 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATF7IP (12p13.1) / ASAP3 (1p36.12)ATF7IP (12p13.1) / ATF7IP (12p13.1)ATF7IP (12p13.1) / ATP6V0E1 (5q35.1)
ATF7IP (12p13.1) / MALAT1 (11q13.1)ATF7IP (12p13.1) / PDGFRB (5q32)ATF7IP (12p13.1) / TMPRSS2 (21q22.3)
ATF7IP (12p13.1) / ZIM2 (19q13.43)COL16A1 (1p35.2) / ATF7IP (12p13.1)TBC1D15 (12q21.1) / ATF7IP (12p13.1)
TMPRSS2 (21q22.3) / ATF7IP (12p13.1)ATF7IP 12p13.1 / TMPRSS2 21q22.3COL16A1 1p35.2 / ATF7IP 12p13.1
TMPRSS2 21q22.3 / ATF7IP 12p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(5;12)(q33;p13) ATF7IP/PDGFRB
t(9;12)(p24;p13) ATF7IP/JAK2


External links

 

Nomenclature
HGNC (Hugo)ATF7IP   20092
Cards
Entrez_Gene (NCBI)ATF7IP    activating transcription factor 7 interacting protein
AliasesAM; ATF-IP; MCAF; MCAF1; 
p621
GeneCards (Weizmann)ATF7IP
Ensembl hg19 (Hinxton)ENSG00000171681 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171681 [Gene_View]  ENSG00000171681 [Sequence]  chr12:14385281-14502930 [Contig_View]  ATF7IP [Vega]
ICGC DataPortalENSG00000171681
TCGA cBioPortalATF7IP
AceView (NCBI)ATF7IP
Genatlas (Paris)ATF7IP
SOURCE (Princeton)ATF7IP
Genetics Home Reference (NIH)ATF7IP
Genomic and cartography
GoldenPath hg38 (UCSC)ATF7IP  -     chr12:14385281-14502930 +  12p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ATF7IP  -     12p13.1   [Description]    (hg19-Feb_2009)
GoldenPathATF7IP - 12p13.1 [CytoView hg19]  ATF7IP - 12p13.1 [CytoView hg38]
ImmunoBaseENSG00000171681
Genome Data Viewer NCBIATF7IP [Mapview hg19]  
OMIM613644   
Gene and transcription
Genbank (Entrez)AF425650 AJ242978 AK001001 AK001550 AK025060
RefSeq transcript (Entrez)NM_001286514 NM_001286515 NM_001388179 NM_001388180 NM_001388181 NM_001388182 NM_001388183 NM_001388184 NM_018179 NM_181352
Consensus coding sequences : CCDS (NCBI)ATF7IP
Gene ExpressionATF7IP [ NCBI-GEO ]   ATF7IP [ EBI - ARRAY_EXPRESS ]   ATF7IP [ SEEK ]   ATF7IP [ MEM ]
Gene Expression Viewer (FireBrowse)ATF7IP [ Firebrowse - Broad ]
GenevisibleExpression of ATF7IP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55729
GTEX Portal (Tissue expression)ATF7IP
Human Protein AtlasENSG00000171681-ATF7IP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6VMQ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6VMQ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6VMQ6
PhosPhoSitePlusQ6VMQ6
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)ATF7-int    ATF7IP_BD    FN3_dom    FN3_sf    Ig-like_fold   
Domain families : Pfam (Sanger)ATF7IP_BD (PF16788)    fn3_4 (PF16794)   
Domain families : Pfam (NCBI)pfam16788    pfam16794   
Conserved Domain (NCBI)ATF7IP
PDB (RSDB)2RPQ   
PDB Europe2RPQ   
PDB (PDBSum)2RPQ   
PDB (IMB)2RPQ   
Structural Biology KnowledgeBase2RPQ   
SCOP (Structural Classification of Proteins)2RPQ   
CATH (Classification of proteins structures)2RPQ   
SuperfamilyQ6VMQ6
AlphaFold pdb e-kbQ6VMQ6   
Human Protein Atlas [tissue]ENSG00000171681-ATF7IP [tissue]
HPRD09811
Protein Interaction databases
DIP (DOE-UCLA)Q6VMQ6
IntAct (EBI)Q6VMQ6
BioGRIDATF7IP
STRING (EMBL)ATF7IP
ZODIACATF7IP
Ontologies - Pathways
QuickGOQ6VMQ6
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytosol  DNA methylation  nuclear body  regulation of protein stability  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  regulation of RNA polymerase II transcription preinitiation complex assembly  protein stabilization  positive regulation of DNA methylation-dependent heterochromatin assembly  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytosol  DNA methylation  nuclear body  regulation of protein stability  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  regulation of RNA polymerase II transcription preinitiation complex assembly  protein stabilization  positive regulation of DNA methylation-dependent heterochromatin assembly  
NDEx NetworkATF7IP
Atlas of Cancer Signalling NetworkATF7IP
Wikipedia pathwaysATF7IP
Orthology - Evolution
OrthoDB55729
GeneTree (enSembl)ENSG00000171681
Phylogenetic Trees/Animal Genes : TreeFamATF7IP
Homologs : HomoloGeneATF7IP
Homology/Alignments : Family Browser (UCSC)ATF7IP
Gene fusions - Rearrangements
Fusion : MitelmanATF7IP/PDGFRB [12p13.1/5q32]  
Fusion : MitelmanATF7IP/TMPRSS2 [12p13.1/21q22.3]  
Fusion : MitelmanCOL16A1/ATF7IP [1p35.2/12p13.1]  
Fusion : MitelmanTMPRSS2/ATF7IP [21q22.3/12p13.1]  
Fusion : QuiverATF7IP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATF7IP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATF7IP
dbVarATF7IP
ClinVarATF7IP
MonarchATF7IP
1000_GenomesATF7IP 
Exome Variant ServerATF7IP
GNOMAD BrowserENSG00000171681
Varsome BrowserATF7IP
ACMGATF7IP variants
VarityQ6VMQ6
Genomic Variants (DGV)ATF7IP [DGVbeta]
DECIPHERATF7IP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisATF7IP 
Mutations
ICGC Data PortalATF7IP 
TCGA Data PortalATF7IP 
Broad Tumor PortalATF7IP
OASIS PortalATF7IP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATF7IP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DATF7IP
Mutations and Diseases : HGMDATF7IP
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaATF7IP
DgiDB (Drug Gene Interaction Database)ATF7IP
DoCM (Curated mutations)ATF7IP
CIViC (Clinical Interpretations of Variants in Cancer)ATF7IP
Cancer3DATF7IP
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613644   
Orphanet
DisGeNETATF7IP
MedgenATF7IP
Genetic Testing Registry ATF7IP
NextProtQ6VMQ6 [Medical]
GENETestsATF7IP
Target ValidationATF7IP
Huge Navigator ATF7IP [HugePedia]
ClinGenATF7IP
Clinical trials, drugs, therapy
MyCancerGenomeATF7IP
Protein Interactions : CTDATF7IP
Pharm GKB GenePA134889460
PharosQ6VMQ6
Clinical trialATF7IP
Miscellaneous
canSAR (ICR)ATF7IP
HarmonizomeATF7IP
DataMed IndexATF7IP
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXATF7IP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:00:25 CEST 2021

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