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ATG16L2 (autophagy related 16 like 2)

Identity

Alias (NCBI)ATG16B
WDR80
HGNC (Hugo) ATG16L2
HGNC Alias symbFLJ00012
WDR80
ATG16B
HGNC Previous nameATG16 autophagy related 16-like 2 (S. cerevisiae)
 autophagy related 16-like 2 (S. cerevisiae)
LocusID (NCBI) 89849
Atlas_Id 54138
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72814411 and ends at 72829635 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATG16L2 (11q13.4) / FCHSD2 (11q13.4)ATG16L2 (11q13.4) / KMT2A (11q23.3)ATG16L2 (11q13.4) / MAGI3 (1p13.2)
LRP5 (11q13.2) / ATG16L2 (11q13.4)ZWILCH (15q22.31) / ATG16L2 (11q13.4)LRP5 11q13.2 / ATG16L2 11q13.4
ZWILCH 15q22.31 / ATG16L2 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  ins(4;11)(q21;q23q23) ATG16L2/KMT2A


External links

 

Nomenclature
HGNC (Hugo)ATG16L2   25464
Cards
Entrez_Gene (NCBI)ATG16L2    autophagy related 16 like 2
AliasesATG16B; WDR80
GeneCards (Weizmann)ATG16L2
Ensembl hg19 (Hinxton)ENSG00000168010 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168010 [Gene_View]  ENSG00000168010 [Sequence]  chr11:72814411-72829635 [Contig_View]  ATG16L2 [Vega]
ICGC DataPortalENSG00000168010
TCGA cBioPortalATG16L2
AceView (NCBI)ATG16L2
Genatlas (Paris)ATG16L2
SOURCE (Princeton)ATG16L2
Genetics Home Reference (NIH)ATG16L2
Genomic and cartography
GoldenPath hg38 (UCSC)ATG16L2  -     chr11:72814411-72829635 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ATG16L2  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathATG16L2 - 11q13.4 [CytoView hg19]  ATG16L2 - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000168010
Genome Data Viewer NCBIATG16L2 [Mapview hg19]  
OMIM618716   
Gene and transcription
Genbank (Entrez)AK024423 AK090597 AK091151 AK093017 AK303270
RefSeq transcript (Entrez)NM_001318766 NM_033388
Consensus coding sequences : CCDS (NCBI)ATG16L2
Gene ExpressionATG16L2 [ NCBI-GEO ]   ATG16L2 [ EBI - ARRAY_EXPRESS ]   ATG16L2 [ SEEK ]   ATG16L2 [ MEM ]
Gene Expression Viewer (FireBrowse)ATG16L2 [ Firebrowse - Broad ]
GenevisibleExpression of ATG16L2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89849
GTEX Portal (Tissue expression)ATG16L2
Human Protein AtlasENSG00000168010-ATG16L2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NAA4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NAA4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NAA4
PhosPhoSitePlusQ8NAA4
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Autophagy-rel_prot_16    G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)ATG16 (PF08614)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam08614    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)ATG16L2
SuperfamilyQ8NAA4
AlphaFold pdb e-kbQ8NAA4   
Human Protein Atlas [tissue]ENSG00000168010-ATG16L2 [tissue]
HPRD10959
Protein Interaction databases
DIP (DOE-UCLA)Q8NAA4
IntAct (EBI)Q8NAA4
BioGRIDATG16L2
STRING (EMBL)ATG16L2
ZODIACATG16L2
Ontologies - Pathways
QuickGOQ8NAA4
Ontology : AmiGOautophagosome assembly  autophagosome assembly  autophagosome membrane  nucleoplasm  autophagosome  cytosol  autophagy  protein transport  negative stranded viral RNA replication  
Ontology : EGO-EBIautophagosome assembly  autophagosome assembly  autophagosome membrane  nucleoplasm  autophagosome  cytosol  autophagy  protein transport  negative stranded viral RNA replication  
Pathways : KEGGRegulation of autophagy   
NDEx NetworkATG16L2
Atlas of Cancer Signalling NetworkATG16L2
Wikipedia pathwaysATG16L2
Orthology - Evolution
OrthoDB89849
GeneTree (enSembl)ENSG00000168010
Phylogenetic Trees/Animal Genes : TreeFamATG16L2
Homologs : HomoloGeneATG16L2
Homology/Alignments : Family Browser (UCSC)ATG16L2
Gene fusions - Rearrangements
Fusion : MitelmanLRP5/ATG16L2 [11q13.2/11q13.4]  
Fusion : MitelmanZWILCH/ATG16L2 [15q22.31/11q13.4]  
Fusion : QuiverATG16L2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATG16L2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATG16L2
dbVarATG16L2
ClinVarATG16L2
MonarchATG16L2
1000_GenomesATG16L2 
Exome Variant ServerATG16L2
GNOMAD BrowserENSG00000168010
Varsome BrowserATG16L2
ACMGATG16L2 variants
VarityQ8NAA4
Genomic Variants (DGV)ATG16L2 [DGVbeta]
DECIPHERATG16L2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisATG16L2 
Mutations
ICGC Data PortalATG16L2 
TCGA Data PortalATG16L2 
Broad Tumor PortalATG16L2
OASIS PortalATG16L2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATG16L2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DATG16L2
Mutations and Diseases : HGMDATG16L2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaATG16L2
DgiDB (Drug Gene Interaction Database)ATG16L2
DoCM (Curated mutations)ATG16L2
CIViC (Clinical Interpretations of Variants in Cancer)ATG16L2
Cancer3DATG16L2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618716   
Orphanet
DisGeNETATG16L2
MedgenATG16L2
Genetic Testing Registry ATG16L2
NextProtQ8NAA4 [Medical]
GENETestsATG16L2
Target ValidationATG16L2
Huge Navigator ATG16L2 [HugePedia]
ClinGenATG16L2
Clinical trials, drugs, therapy
MyCancerGenomeATG16L2
Protein Interactions : CTDATG16L2
Pharm GKB GenePA142672575
PharosQ8NAA4
Clinical trialATG16L2
Miscellaneous
canSAR (ICR)ATG16L2
HarmonizomeATG16L2
DataMed IndexATG16L2
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXATG16L2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:00:26 CEST 2021

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