ATG2A (autophagy related 2A)

2014-11-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 23130
MIM: 616225
HGNC: 29028
Ensembl: ENSG00000110046

Variants:

dbSNP: 23130
ClinVar: 23130
TCGA: ENSG00000110046
COSMIC: ATG2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110046ENST00000377264Q2TAZ0
ENSG00000110046ENST00000418259H7C3T2
ENSG00000110046ENST00000421419Q2TAZ0

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
222193742012Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.120
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
309528002019ATG2 transports lipids to promote autophagosome biogenesis.27
288001312017Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis.20
247765412014Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells.17
291130292017Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets.16
312713522019The autophagic membrane tether ATG2A transfers lipids between membranes.14
284102022017Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese by exome-wide association studies.5
218874082011Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Δ strain.3

Citation

Dessen P

ATG2A (autophagy related 2A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60597/atg2a