Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ATG4A (autophagy related 4A cysteine peptidase)

Identity

Alias_namesAUTL2
APG4A
AUT-like 2, cysteine endopeptidase (S. cerevisiae)
APG4 autophagy 4 homolog A (S. cerevisiae)
ATG4 autophagy related 4 homolog A (S. cerevisiae)
autophagy related 4A, cysteine peptidase
Other alias
HGNC (Hugo) ATG4A
LocusID (NCBI) 115201
Atlas_Id 671
Location Xq22.3  [Link to chromosome band Xq22]
Location_base_pair Starts at 107334899 and ends at 107397901 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ATG4A   16489
Cards
Entrez_Gene (NCBI)ATG4A  115201  autophagy related 4A cysteine peptidase
AliasesAPG4A; AUTL2
GeneCards (Weizmann)ATG4A
Ensembl hg19 (Hinxton)ENSG00000101844 [Gene_View]  chrX:107334899-107397901 [Contig_View]  ATG4A [Vega]
Ensembl hg38 (Hinxton)ENSG00000101844 [Gene_View]  chrX:107334899-107397901 [Contig_View]  ATG4A [Vega]
ICGC DataPortalENSG00000101844
TCGA cBioPortalATG4A
AceView (NCBI)ATG4A
Genatlas (Paris)ATG4A
WikiGenes115201
SOURCE (Princeton)ATG4A
Genetics Home Reference (NIH)ATG4A
Genomic and cartography
GoldenPath hg19 (UCSC)ATG4A  -     chrX:107334899-107397901 +  Xq22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ATG4A  -     Xq22.3   [Description]    (hg38-Dec_2013)
EnsemblATG4A - Xq22.3 [CytoView hg19]  ATG4A - Xq22.3 [CytoView hg38]
Mapping of homologs : NCBIATG4A [Mapview hg19]  ATG4A [Mapview hg38]
OMIM300663   
Gene and transcription
Genbank (Entrez)AA648264 AB066214 AJ320508 AJ320509 AJ504651
RefSeq transcript (Entrez)NM_001321287 NM_001321288 NM_001321289 NM_001321290 NM_052936 NM_178270 NM_178271
RefSeq genomic (Entrez)NC_000023 NC_018934 NT_011651 NW_004929444
Consensus coding sequences : CCDS (NCBI)ATG4A
Cluster EST : UnigeneHs.8763 [ NCBI ]
CGAP (NCI)Hs.8763
Alternative Splicing GalleryENSG00000101844
Gene ExpressionATG4A [ NCBI-GEO ]   ATG4A [ EBI - ARRAY_EXPRESS ]   ATG4A [ SEEK ]   ATG4A [ MEM ]
Gene Expression Viewer (FireBrowse)ATG4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115201
GTEX Portal (Tissue expression)ATG4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WYN0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WYN0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WYN0
Splice isoforms : SwissVarQ8WYN0
Catalytic activity : Enzyme3.4.22.- [ Enzyme-Expasy ]   3.4.22.-3.4.22.- [ IntEnz-EBI ]   3.4.22.- [ BRENDA ]   3.4.22.- [ KEGG ]   
PhosPhoSitePlusQ8WYN0
Domains : Interpro (EBI)Peptidase_C54   
Domain families : Pfam (Sanger)Peptidase_C54 (PF03416)   
Domain families : Pfam (NCBI)pfam03416   
Conserved Domain (NCBI)ATG4A
DMDM Disease mutations115201
Blocks (Seattle)ATG4A
PDB (SRS)2FUY    2P82   
PDB (PDBSum)2FUY    2P82   
PDB (IMB)2FUY    2P82   
PDB (RSDB)2FUY    2P82   
Structural Biology KnowledgeBase2FUY    2P82   
SCOP (Structural Classification of Proteins)2FUY    2P82   
CATH (Classification of proteins structures)2FUY    2P82   
SuperfamilyQ8WYN0
Human Protein AtlasENSG00000101844
Peptide AtlasQ8WYN0
HPRD06455
IPIIPI00292327   IPI00064708   IPI00328880   IPI00640839   IPI01014972   IPI00853512   IPI00184556   
Protein Interaction databases
DIP (DOE-UCLA)Q8WYN0
IntAct (EBI)Q8WYN0
FunCoupENSG00000101844
BioGRIDATG4A
STRING (EMBL)ATG4A
ZODIACATG4A
Ontologies - Pathways
QuickGOQ8WYN0
Ontology : AmiGOautophagosome assembly  mitophagy  cysteine-type endopeptidase activity  protein binding  cytoplasm  cytosol  C-terminal protein lipidation  proteolysis  protein targeting to membrane  cysteine-type peptidase activity  protein processing  nucleophagy  protein delipidation  
Ontology : EGO-EBIautophagosome assembly  mitophagy  cysteine-type endopeptidase activity  protein binding  cytoplasm  cytosol  C-terminal protein lipidation  proteolysis  protein targeting to membrane  cysteine-type peptidase activity  protein processing  nucleophagy  protein delipidation  
Pathways : KEGGRegulation of autophagy   
NDEx NetworkATG4A
Atlas of Cancer Signalling NetworkATG4A
Wikipedia pathwaysATG4A
Orthology - Evolution
OrthoDB115201
GeneTree (enSembl)ENSG00000101844
Phylogenetic Trees/Animal Genes : TreeFamATG4A
HOVERGENQ8WYN0
HOGENOMQ8WYN0
Homologs : HomoloGeneATG4A
Homology/Alignments : Family Browser (UCSC)ATG4A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATG4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATG4A
dbVarATG4A
ClinVarATG4A
1000_GenomesATG4A 
Exome Variant ServerATG4A
ExAC (Exome Aggregation Consortium)ATG4A (select the gene name)
Genetic variants : HAPMAP115201
Genomic Variants (DGV)ATG4A [DGVbeta]
DECIPHER (Syndromes)X:107334899-107397901  ENSG00000101844
CONAN: Copy Number AnalysisATG4A 
Mutations
ICGC Data PortalATG4A 
TCGA Data PortalATG4A 
Broad Tumor PortalATG4A
OASIS PortalATG4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATG4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDATG4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATG4A
DgiDB (Drug Gene Interaction Database)ATG4A
DoCM (Curated mutations)ATG4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATG4A (select a term)
intoGenATG4A
Cancer3DATG4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300663   
Orphanet
MedgenATG4A
Genetic Testing Registry ATG4A
NextProtQ8WYN0 [Medical]
TSGene115201
GENETestsATG4A
Huge Navigator ATG4A [HugePedia]
snp3D : Map Gene to Disease115201
BioCentury BCIQATG4A
ClinGenATG4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115201
Chemical/Pharm GKB GenePA25184
Clinical trialATG4A
Miscellaneous
canSAR (ICR)ATG4A (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATG4A
EVEXATG4A
GoPubMedATG4A
iHOPATG4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:53:19 CEST 2017

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