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ATG4C (autophagy related 4C cysteine peptidase)

Identity

Alias (NCBI)APG4-C
APG4C
AUTL1
AUTL3
HGNC (Hugo) ATG4C
HGNC Alias symbFLJ14867
AUTL3
HGNC Previous nameAUTL1
 APG4C
HGNC Previous nameAUT (S. cerevisiae)-like 1, cysteine endopeptidase; AUT-like 1, cysteine endopeptidase (S. cerevisiae)
 APG4 autophagy 4 homolog C (S. cerevisiae)
 ATG4 autophagy related 4 homolog C (S. cerevisiae)
 autophagy related 4C, cysteine peptidase
LocusID (NCBI) 84938
Atlas_Id 673
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 62784106 and ends at 62865271 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATG4C (1p31.3) / ATG4C (1p31.3)ATG4C (1p31.3) / C18orf42 (18p11.31)ATG4C (1p31.3) / FBXO38 (5q32)
ATG4C (1p31.3) / NFIA (1p31.3)ATG4C (1p31.3) / PATJ (1p31.3)CTR9 (11p15.3) / ATG4C (1p31.3)
ATG4C 1p31.3 / FBXO38 5q32ATG4C 1p31.3 / C18orf42 18p11.31ATG4C 1p31.3 / INADL 1p31.3
ATG4C 1p31.3 / NFIA 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ATG4C   16040
Cards
Entrez_Gene (NCBI)ATG4C    autophagy related 4C cysteine peptidase
AliasesAPG4-C; APG4C; AUTL1; AUTL3
GeneCards (Weizmann)ATG4C
Ensembl hg19 (Hinxton)ENSG00000125703 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125703 [Gene_View]  ENSG00000125703 [Sequence]  chr1:62784106-62865271 [Contig_View]  ATG4C [Vega]
ICGC DataPortalENSG00000125703
TCGA cBioPortalATG4C
AceView (NCBI)ATG4C
Genatlas (Paris)ATG4C
SOURCE (Princeton)ATG4C
Genetics Home Reference (NIH)ATG4C
Genomic and cartography
GoldenPath hg38 (UCSC)ATG4C  -     chr1:62784106-62865271 +  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ATG4C  -     1p31.3   [Description]    (hg19-Feb_2009)
GoldenPathATG4C - 1p31.3 [CytoView hg19]  ATG4C - 1p31.3 [CytoView hg38]
ImmunoBaseENSG00000125703
Genome Data Viewer NCBIATG4C [Mapview hg19]  
OMIM611339   
Gene and transcription
Genbank (Entrez)AJ312234 AJ320169 AK027773 BC008395 BC018678
RefSeq transcript (Entrez)NM_032852 NM_178221
Consensus coding sequences : CCDS (NCBI)ATG4C
Gene ExpressionATG4C [ NCBI-GEO ]   ATG4C [ EBI - ARRAY_EXPRESS ]   ATG4C [ SEEK ]   ATG4C [ MEM ]
Gene Expression Viewer (FireBrowse)ATG4C [ Firebrowse - Broad ]
GenevisibleExpression of ATG4C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84938
GTEX Portal (Tissue expression)ATG4C
Human Protein AtlasENSG00000125703-ATG4C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96DT6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96DT6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96DT6
Catalytic activity : Enzyme3.4.22.- [ Enzyme-Expasy ]   3.4.22.-3.4.22.- [ IntEnz-EBI ]   3.4.22.- [ BRENDA ]   3.4.22.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96DT6
Domains : Interpro (EBI)ATG4C    Papain-like_cys_pep_sf    Peptidase_C54   
Domain families : Pfam (Sanger)Peptidase_C54 (PF03416)   
Domain families : Pfam (NCBI)pfam03416   
Conserved Domain (NCBI)ATG4C
SuperfamilyQ96DT6
AlphaFold pdb e-kbQ96DT6   
Human Protein Atlas [tissue]ENSG00000125703-ATG4C [tissue]
HPRD07473
Protein Interaction databases
DIP (DOE-UCLA)Q96DT6
IntAct (EBI)Q96DT6
BioGRIDATG4C
STRING (EMBL)ATG4C
ZODIACATG4C
Ontologies - Pathways
QuickGOQ96DT6
Ontology : AmiGOcysteine-type endopeptidase activity  protein binding  cellular_component  cytoplasm  proteolysis  autophagy  cysteine-type peptidase activity  protein transport  
Ontology : EGO-EBIcysteine-type endopeptidase activity  protein binding  cellular_component  cytoplasm  proteolysis  autophagy  cysteine-type peptidase activity  protein transport  
Pathways : KEGGRegulation of autophagy   
NDEx NetworkATG4C
Atlas of Cancer Signalling NetworkATG4C
Wikipedia pathwaysATG4C
Orthology - Evolution
OrthoDB84938
GeneTree (enSembl)ENSG00000125703
Phylogenetic Trees/Animal Genes : TreeFamATG4C
Homologs : HomoloGeneATG4C
Homology/Alignments : Family Browser (UCSC)ATG4C
Gene fusions - Rearrangements
Fusion : MitelmanATG4C/C18orf42 [1p31.3/18p11.31]  
Fusion : MitelmanATG4C/INADL [1p31.3/1p31.3]  
Fusion : MitelmanATG4C/NFIA [1p31.3/1p31.3]  
Fusion : QuiverATG4C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATG4C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATG4C
dbVarATG4C
ClinVarATG4C
MonarchATG4C
1000_GenomesATG4C 
Exome Variant ServerATG4C
GNOMAD BrowserENSG00000125703
Varsome BrowserATG4C
ACMGATG4C variants
VarityQ96DT6
Genomic Variants (DGV)ATG4C [DGVbeta]
DECIPHERATG4C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisATG4C 
Mutations
ICGC Data PortalATG4C 
TCGA Data PortalATG4C 
Broad Tumor PortalATG4C
OASIS PortalATG4C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATG4C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DATG4C
Mutations and Diseases : HGMDATG4C
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaATG4C
DgiDB (Drug Gene Interaction Database)ATG4C
DoCM (Curated mutations)ATG4C
CIViC (Clinical Interpretations of Variants in Cancer)ATG4C
Cancer3DATG4C
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611339   
Orphanet
DisGeNETATG4C
MedgenATG4C
Genetic Testing Registry ATG4C
NextProtQ96DT6 [Medical]
GENETestsATG4C
Target ValidationATG4C
Huge Navigator ATG4C [HugePedia]
ClinGenATG4C
Clinical trials, drugs, therapy
MyCancerGenomeATG4C
Protein Interactions : CTDATG4C
Pharm GKB GenePA25183
PharosQ96DT6
Clinical trialATG4C
Miscellaneous
canSAR (ICR)ATG4C
HarmonizomeATG4C
DataMed IndexATG4C
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXATG4C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:00:27 CEST 2021

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