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ATG4C (autophagy related 4C cysteine peptidase)

Identity

Alias_namesAUTL1
APG4C
AUT (S. cerevisiae)-like 1, cysteine endopeptidase; AUT-like 1, cysteine endopeptidase (S. cerevisiae)
APG4 autophagy 4 homolog C (S. cerevisiae)
ATG4 autophagy related 4 homolog C (S. cerevisiae)
autophagy related 4C, cysteine peptidase
Alias_symbol (synonym)FLJ14867
AUTL3
Other aliasAPG4-C
HGNC (Hugo) ATG4C
LocusID (NCBI) 84938
Atlas_Id 673
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 63249777 and ends at 63330941 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATG4C (1p31.3) / ATG4C (1p31.3)ATG4C (1p31.3) / C18orf42 (18p11.31)ATG4C (1p31.3) / FBXO38 (5q32)
ATG4C (1p31.3) / NFIA (1p31.3)ATG4C (1p31.3) / PATJ (1p31.3)CTR9 (11p15.3) / ATG4C (1p31.3)
ATG4C 1p31.3 / FBXO38 5q32ATG4C 1p31.3 / C18orf42 18p11.31ATG4C 1p31.3 / INADL 1p31.3
ATG4C 1p31.3 / NFIA 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ATG4C   16040
Cards
Entrez_Gene (NCBI)ATG4C  84938  autophagy related 4C cysteine peptidase
AliasesAPG4-C; APG4C; AUTL1; AUTL3
GeneCards (Weizmann)ATG4C
Ensembl hg19 (Hinxton)ENSG00000125703 [Gene_View]  chr1:63249777-63330941 [Contig_View]  ATG4C [Vega]
Ensembl hg38 (Hinxton)ENSG00000125703 [Gene_View]  chr1:63249777-63330941 [Contig_View]  ATG4C [Vega]
ICGC DataPortalENSG00000125703
TCGA cBioPortalATG4C
AceView (NCBI)ATG4C
Genatlas (Paris)ATG4C
WikiGenes84938
SOURCE (Princeton)ATG4C
Genetics Home Reference (NIH)ATG4C
Genomic and cartography
GoldenPath hg19 (UCSC)ATG4C  -     chr1:63249777-63330941 +  1p31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ATG4C  -     1p31.3   [Description]    (hg38-Dec_2013)
EnsemblATG4C - 1p31.3 [CytoView hg19]  ATG4C - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBIATG4C [Mapview hg19]  ATG4C [Mapview hg38]
OMIM611339   
Gene and transcription
Genbank (Entrez)AJ312234 AJ320169 AK027773 BC008395 BC018678
RefSeq transcript (Entrez)NM_032852 NM_178221
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)ATG4C
Cluster EST : UnigeneHs.7353 [ NCBI ]
CGAP (NCI)Hs.7353
Alternative Splicing GalleryENSG00000125703
Gene ExpressionATG4C [ NCBI-GEO ]   ATG4C [ EBI - ARRAY_EXPRESS ]   ATG4C [ SEEK ]   ATG4C [ MEM ]
Gene Expression Viewer (FireBrowse)ATG4C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84938
GTEX Portal (Tissue expression)ATG4C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96DT6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96DT6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96DT6
Splice isoforms : SwissVarQ96DT6
Catalytic activity : Enzyme3.4.22.- [ Enzyme-Expasy ]   3.4.22.-3.4.22.- [ IntEnz-EBI ]   3.4.22.- [ BRENDA ]   3.4.22.- [ KEGG ]   
PhosPhoSitePlusQ96DT6
Domains : Interpro (EBI)ATG4C    Peptidase_C54   
Domain families : Pfam (Sanger)Peptidase_C54 (PF03416)   
Domain families : Pfam (NCBI)pfam03416   
Conserved Domain (NCBI)ATG4C
DMDM Disease mutations84938
Blocks (Seattle)ATG4C
SuperfamilyQ96DT6
Human Protein AtlasENSG00000125703
Peptide AtlasQ96DT6
HPRD07473
IPIIPI00156979   IPI00793245   IPI00644762   IPI00641402   
Protein Interaction databases
DIP (DOE-UCLA)Q96DT6
IntAct (EBI)Q96DT6
FunCoupENSG00000125703
BioGRIDATG4C
STRING (EMBL)ATG4C
ZODIACATG4C
Ontologies - Pathways
QuickGOQ96DT6
Ontology : AmiGOautophagosome assembly  mitophagy  cysteine-type endopeptidase activity  extracellular region  cytoplasm  cytosol  cytosol  C-terminal protein lipidation  proteolysis  protein targeting to membrane  protein targeting to membrane  autophagy  peptidase activity  protein processing  nucleophagy  protein delipidation  
Ontology : EGO-EBIautophagosome assembly  mitophagy  cysteine-type endopeptidase activity  extracellular region  cytoplasm  cytosol  cytosol  C-terminal protein lipidation  proteolysis  protein targeting to membrane  protein targeting to membrane  autophagy  peptidase activity  protein processing  nucleophagy  protein delipidation  
Pathways : KEGGRegulation of autophagy   
NDEx NetworkATG4C
Atlas of Cancer Signalling NetworkATG4C
Wikipedia pathwaysATG4C
Orthology - Evolution
OrthoDB84938
GeneTree (enSembl)ENSG00000125703
Phylogenetic Trees/Animal Genes : TreeFamATG4C
HOVERGENQ96DT6
HOGENOMQ96DT6
Homologs : HomoloGeneATG4C
Homology/Alignments : Family Browser (UCSC)ATG4C
Gene fusions - Rearrangements
Fusion : MitelmanATG4C/C18orf42 [1p31.3/18p11.31]  
Fusion : MitelmanATG4C/INADL [1p31.3/1p31.3]  [t(1;1)(p31;p31)]  
Fusion : MitelmanATG4C/NFIA [1p31.3/1p31.3]  [t(1;1)(p31;p31)]  
Fusion: TCGAATG4C 1p31.3 C18orf42 18p11.31 PRAD
Fusion: TCGAATG4C 1p31.3 INADL 1p31.3 LGG
Fusion: TCGAATG4C 1p31.3 NFIA 1p31.3 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATG4C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATG4C
dbVarATG4C
ClinVarATG4C
1000_GenomesATG4C 
Exome Variant ServerATG4C
ExAC (Exome Aggregation Consortium)ATG4C (select the gene name)
Genetic variants : HAPMAP84938
Genomic Variants (DGV)ATG4C [DGVbeta]
DECIPHER (Syndromes)1:63249777-63330941  ENSG00000125703
CONAN: Copy Number AnalysisATG4C 
Mutations
ICGC Data PortalATG4C 
TCGA Data PortalATG4C 
Broad Tumor PortalATG4C
OASIS PortalATG4C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATG4C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDATG4C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATG4C
DgiDB (Drug Gene Interaction Database)ATG4C
DoCM (Curated mutations)ATG4C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATG4C (select a term)
intoGenATG4C
Cancer3DATG4C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611339   
Orphanet
MedgenATG4C
Genetic Testing Registry ATG4C
NextProtQ96DT6 [Medical]
TSGene84938
GENETestsATG4C
Huge Navigator ATG4C [HugePedia]
snp3D : Map Gene to Disease84938
BioCentury BCIQATG4C
ClinGenATG4C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84938
Chemical/Pharm GKB GenePA25183
Clinical trialATG4C
Miscellaneous
canSAR (ICR)ATG4C (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATG4C
EVEXATG4C
GoPubMedATG4C
iHOPATG4C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:56:51 CET 2017

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