ATG7 (autophagy related 7)

2013-11-01  

Identity

HGNC
ATG7
LOCATION
3p25.3
LOCUSID
10533
ALIAS
APG7-LIKE,APG7L,GSA7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10533
MIM: 608760
HGNC: 16935
Ensembl: ENSG00000197548

Variants:

dbSNP: 10533
ClinVar: 10533
TCGA: ENSG00000197548
COSMIC: ATG7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197548ENST00000354449O95352
ENSG00000197548ENST00000354956O95352
ENSG00000197548ENST00000414717H7C2R3
ENSG00000197548ENST00000418682F8WDY9
ENSG00000197548ENST00000419112C9JNU2
ENSG00000197548ENST00000423116C9JE55
ENSG00000197548ENST00000424071H7C369
ENSG00000197548ENST00000427759H7BZ92
ENSG00000197548ENST00000434066H7C059
ENSG00000197548ENST00000435760C9JGL2
ENSG00000197548ENST00000444619C9JKA3
ENSG00000197548ENST00000446110H7C2J8
ENSG00000197548ENST00000446450O95352
ENSG00000197548ENST00000451513C9JFF4
ENSG00000197548ENST00000451830C9J415

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Neutrophil degranulationREACTOMER-HSA-6798695
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952
Autophagy - otherKEGGko04136
FerroptosisKEGGko04216
Autophagy - otherKEGGhsa04136
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205438402010Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.193
186888772008Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response.183
191482252009PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.135
198815382010Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells.127
272457392016Autophagy promotes ferroptosis by degradation of ferritin.120
224999452012Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.114
212748622011Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes.104
191244662009Regulation of autophagy by the p300 acetyltransferase.86
216550942011EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Dessen P

ATG7 (autophagy related 7)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53558/atg7