Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ATOH1 (atonal bHLH transcription factor 1)

Identity

Alias_namesatonal homolog 1 (Drosophila)
atonal homolog bHLH transcription factor 1
Alias_symbol (synonym)HATH1
MATH-1
Math1
bHLHa14
Other aliasATH1
HGNC (Hugo) ATOH1
LocusID (NCBI) 474
Atlas_Id 43839
Location 4q22.2  [Link to chromosome band 4q22]
Location_base_pair Starts at 93828927 and ends at 93829991 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ATOH1   797
Cards
Entrez_Gene (NCBI)ATOH1  474  atonal bHLH transcription factor 1
AliasesATH1; HATH1; MATH-1; bHLHa14
GeneCards (Weizmann)ATOH1
Ensembl hg19 (Hinxton)ENSG00000172238 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172238 [Gene_View]  chr4:93828927-93829991 [Contig_View]  ATOH1 [Vega]
ICGC DataPortalENSG00000172238
TCGA cBioPortalATOH1
AceView (NCBI)ATOH1
Genatlas (Paris)ATOH1
WikiGenes474
SOURCE (Princeton)ATOH1
Genetics Home Reference (NIH)ATOH1
Genomic and cartography
GoldenPath hg38 (UCSC)ATOH1  -     chr4:93828927-93829991 +  4q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ATOH1  -     4q22.2   [Description]    (hg19-Feb_2009)
EnsemblATOH1 - 4q22.2 [CytoView hg19]  ATOH1 - 4q22.2 [CytoView hg38]
Mapping of homologs : NCBIATOH1 [Mapview hg19]  ATOH1 [Mapview hg38]
OMIM601461   
Gene and transcription
Genbank (Entrez)BC069145 BC069578 BC069594 BC069604 BC113623
RefSeq transcript (Entrez)NM_005172
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ATOH1
Cluster EST : UnigeneHs.532680 [ NCBI ]
CGAP (NCI)Hs.532680
Alternative Splicing GalleryENSG00000172238
Gene ExpressionATOH1 [ NCBI-GEO ]   ATOH1 [ EBI - ARRAY_EXPRESS ]   ATOH1 [ SEEK ]   ATOH1 [ MEM ]
Gene Expression Viewer (FireBrowse)ATOH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)474
GTEX Portal (Tissue expression)ATOH1
Human Protein AtlasENSG00000172238-ATOH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92858   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92858  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92858
Splice isoforms : SwissVarQ92858
PhosPhoSitePlusQ92858
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)ATOH1    bHLH_dom   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)ATOH1
DMDM Disease mutations474
Blocks (Seattle)ATOH1
SuperfamilyQ92858
Human Protein Atlas [tissue]ENSG00000172238-ATOH1 [tissue]
Peptide AtlasQ92858
HPRD03270
IPIIPI00023811   
Protein Interaction databases
DIP (DOE-UCLA)Q92858
IntAct (EBI)Q92858
FunCoupENSG00000172238
BioGRIDATOH1
STRING (EMBL)ATOH1
ZODIACATOH1
Ontologies - Pathways
QuickGOQ92858
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  neuron migration  transcription factor activity, sequence-specific DNA binding  nucleus  transcription from RNA polymerase II promoter  Notch signaling pathway  axon guidance  central nervous system development  cerebral cortex development  chromatin DNA binding  inner ear morphogenesis  auditory receptor cell fate specification  auditory receptor cell fate determination  negative regulation of apoptotic process  positive regulation of auditory receptor cell differentiation  positive regulation of neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  neuron migration  transcription factor activity, sequence-specific DNA binding  nucleus  transcription from RNA polymerase II promoter  Notch signaling pathway  axon guidance  central nervous system development  cerebral cortex development  chromatin DNA binding  inner ear morphogenesis  auditory receptor cell fate specification  auditory receptor cell fate determination  negative regulation of apoptotic process  positive regulation of auditory receptor cell differentiation  positive regulation of neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  
NDEx NetworkATOH1
Atlas of Cancer Signalling NetworkATOH1
Wikipedia pathwaysATOH1
Orthology - Evolution
OrthoDB474
GeneTree (enSembl)ENSG00000172238
Phylogenetic Trees/Animal Genes : TreeFamATOH1
HOVERGENQ92858
HOGENOMQ92858
Homologs : HomoloGeneATOH1
Homology/Alignments : Family Browser (UCSC)ATOH1
Gene fusions - Rearrangements
Tumor Fusion PortalATOH1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATOH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATOH1
dbVarATOH1
ClinVarATOH1
1000_GenomesATOH1 
Exome Variant ServerATOH1
ExAC (Exome Aggregation Consortium)ENSG00000172238
GNOMAD BrowserENSG00000172238
Genetic variants : HAPMAP474
Genomic Variants (DGV)ATOH1 [DGVbeta]
DECIPHERATOH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisATOH1 
Mutations
ICGC Data PortalATOH1 
TCGA Data PortalATOH1 
Broad Tumor PortalATOH1
OASIS PortalATOH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATOH1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDATOH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATOH1
DgiDB (Drug Gene Interaction Database)ATOH1
DoCM (Curated mutations)ATOH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATOH1 (select a term)
intoGenATOH1
Cancer3DATOH1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601461   
Orphanet
DisGeNETATOH1
MedgenATOH1
Genetic Testing Registry ATOH1
NextProtQ92858 [Medical]
TSGene474
GENETestsATOH1
Target ValidationATOH1
Huge Navigator ATOH1 [HugePedia]
snp3D : Map Gene to Disease474
BioCentury BCIQATOH1
ClinGenATOH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD474
Chemical/Pharm GKB GenePA25095
Clinical trialATOH1
Miscellaneous
canSAR (ICR)ATOH1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATOH1
EVEXATOH1
GoPubMedATOH1
iHOPATOH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:04:07 CET 2017

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