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ATP1A4 (ATPase Na+/K+ transporting subunit alpha 4)

Identity

Alias_namesATP1AL2
ATPase, Na+/K+ transporting, alpha polypeptide-like 2
ATPase, Na+/K+ transporting, alpha 4 polypeptide
Other aliasATP1A1
HGNC (Hugo) ATP1A4
LocusID (NCBI) 480
Atlas_Id 60617
Location 1q23.2  [Link to chromosome band 1q23]
Location_base_pair Starts at 160177411 and ends at 160186977 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AGPAT3 (21q22.3) / ATP1A4 (1q23.2)NCSTN (1q23.2) / ATP1A4 (1q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ATP1A4   14073
Cards
Entrez_Gene (NCBI)ATP1A4  480  ATPase Na+/K+ transporting subunit alpha 4
AliasesATP1A1; ATP1AL2
GeneCards (Weizmann)ATP1A4
Ensembl hg19 (Hinxton)ENSG00000132681 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132681 [Gene_View]  chr1:160177411-160186977 [Contig_View]  ATP1A4 [Vega]
ICGC DataPortalENSG00000132681
TCGA cBioPortalATP1A4
AceView (NCBI)ATP1A4
Genatlas (Paris)ATP1A4
WikiGenes480
SOURCE (Princeton)ATP1A4
Genetics Home Reference (NIH)ATP1A4
Genomic and cartography
GoldenPath hg38 (UCSC)ATP1A4  -     chr1:160177411-160186977 +  1q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ATP1A4  -     1q23.2   [Description]    (hg19-Feb_2009)
EnsemblATP1A4 - 1q23.2 [CytoView hg19]  ATP1A4 - 1q23.2 [CytoView hg38]
Mapping of homologs : NCBIATP1A4 [Mapview hg19]  ATP1A4 [Mapview hg38]
OMIM607321   
Gene and transcription
Genbank (Entrez)AF459737 AF506797 AK098076 AK308286 AL833335
RefSeq transcript (Entrez)NM_001001734 NM_144699
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ATP1A4
Cluster EST : UnigeneHs.662219 [ NCBI ]
CGAP (NCI)Hs.662219
Alternative Splicing GalleryENSG00000132681
Gene ExpressionATP1A4 [ NCBI-GEO ]   ATP1A4 [ EBI - ARRAY_EXPRESS ]   ATP1A4 [ SEEK ]   ATP1A4 [ MEM ]
Gene Expression Viewer (FireBrowse)ATP1A4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)480
GTEX Portal (Tissue expression)ATP1A4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13733   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13733  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13733
Splice isoforms : SwissVarQ13733
Catalytic activity : Enzyme3.6.3.9 [ Enzyme-Expasy ]   3.6.3.93.6.3.9 [ IntEnz-EBI ]   3.6.3.9 [ BRENDA ]   3.6.3.9 [ KEGG ]   
PhosPhoSitePlusQ13733
Domaine pattern : Prosite (Expaxy)ATPASE_E1_E2 (PS00154)   
Domains : Interpro (EBI)ATPase_P-typ_cation-transptr_C    ATPase_P-typ_cation-transptr_N    ATPase_P-typ_cyto_domN    ATPase_P-typ_P_site    ATPase_P-typ_TM_dom    ATPase_P-typ_transduc_dom_A    HAD-like_dom    P-type_ATPase_IIC    P_typ_ATPase   
Domain families : Pfam (Sanger)Cation_ATPase_C (PF00689)    Cation_ATPase_N (PF00690)    E1-E2_ATPase (PF00122)   
Domain families : Pfam (NCBI)pfam00689    pfam00690    pfam00122   
Domain families : Smart (EMBL)Cation_ATPase_N (SM00831)  
Conserved Domain (NCBI)ATP1A4
DMDM Disease mutations480
Blocks (Seattle)ATP1A4
SuperfamilyQ13733
Human Protein AtlasENSG00000132681
Peptide AtlasQ13733
HPRD09541
IPIIPI00375339   IPI00252122   IPI00984044   
Protein Interaction databases
DIP (DOE-UCLA)Q13733
IntAct (EBI)Q13733
FunCoupENSG00000132681
BioGRIDATP1A4
STRING (EMBL)ATP1A4
ZODIACATP1A4
Ontologies - Pathways
QuickGOQ13733
Ontology : AmiGOsodium:potassium-exchanging ATPase activity  ATP binding  plasma membrane  integral component of plasma membrane  sodium:potassium-exchanging ATPase complex  potassium ion transport  sodium ion transport  spermatogenesis  fertilization  establishment or maintenance of transmembrane electrochemical gradient  ATP hydrolysis coupled proton transport  flagellated sperm motility  regulation of cellular pH  ion transmembrane transport  regulation of membrane potential  metal ion binding  regulation of cardiac conduction  
Ontology : EGO-EBIsodium:potassium-exchanging ATPase activity  ATP binding  plasma membrane  integral component of plasma membrane  sodium:potassium-exchanging ATPase complex  potassium ion transport  sodium ion transport  spermatogenesis  fertilization  establishment or maintenance of transmembrane electrochemical gradient  ATP hydrolysis coupled proton transport  flagellated sperm motility  regulation of cellular pH  ion transmembrane transport  regulation of membrane potential  metal ion binding  regulation of cardiac conduction  
Pathways : KEGGCardiac muscle contraction    Adrenergic signaling in cardiomyocytes    Insulin secretion    Thyroid hormone synthesis    Thyroid hormone signaling pathway    Aldosterone-regulated sodium reabsorption    Endocrine and other factor-regulated calcium reabsorption    Proximal tubule bicarbonate reclamation    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Carbohydrate digestion and absorption    Protein digestion and absorption    Bile secretion    Mineral absorption   
NDEx NetworkATP1A4
Atlas of Cancer Signalling NetworkATP1A4
Wikipedia pathwaysATP1A4
Orthology - Evolution
OrthoDB480
GeneTree (enSembl)ENSG00000132681
Phylogenetic Trees/Animal Genes : TreeFamATP1A4
HOVERGENQ13733
HOGENOMQ13733
Homologs : HomoloGeneATP1A4
Homology/Alignments : Family Browser (UCSC)ATP1A4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATP1A4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATP1A4
dbVarATP1A4
ClinVarATP1A4
1000_GenomesATP1A4 
Exome Variant ServerATP1A4
ExAC (Exome Aggregation Consortium)ATP1A4 (select the gene name)
Genetic variants : HAPMAP480
Genomic Variants (DGV)ATP1A4 [DGVbeta]
DECIPHERATP1A4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisATP1A4 
Mutations
ICGC Data PortalATP1A4 
TCGA Data PortalATP1A4 
Broad Tumor PortalATP1A4
OASIS PortalATP1A4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATP1A4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDATP1A4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATP1A4
DgiDB (Drug Gene Interaction Database)ATP1A4
DoCM (Curated mutations)ATP1A4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATP1A4 (select a term)
intoGenATP1A4
Cancer3DATP1A4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607321   
Orphanet
MedgenATP1A4
Genetic Testing Registry ATP1A4
NextProtQ13733 [Medical]
TSGene480
GENETestsATP1A4
Target ValidationATP1A4
Huge Navigator ATP1A4 [HugePedia]
snp3D : Map Gene to Disease480
BioCentury BCIQATP1A4
ClinGenATP1A4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD480
Chemical/Pharm GKB GenePA65
Clinical trialATP1A4
Miscellaneous
canSAR (ICR)ATP1A4 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATP1A4
EVEXATP1A4
GoPubMedATP1A4
iHOPATP1A4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:39:10 CEST 2017

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