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ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)

Identity

Alias_namesATPase
Alias_symbol (synonym)SERCA3
Other alias
HGNC (Hugo) ATP2A3
LocusID (NCBI) 489
Atlas_Id 724
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 3923869 and ends at 3964464 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASTN1 (1q25.2) / ATP2A3 (17p13.2)ATP2A3 (17p13.2) / FGF3 (11q13.3)ATP2A3 (17p13.2) / RTEL1 (20q13.33)
USP22 (17p11.2) / ATP2A3 (17p13.2)ATP2A3 17p13.2 / FGF3 11q13.3USP22 17p11.2 / ATP2A3 17p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ATP2A3   813
Cards
Entrez_Gene (NCBI)ATP2A3  489  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
AliasesSERCA3
GeneCards (Weizmann)ATP2A3
Ensembl hg19 (Hinxton)ENSG00000074370 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074370 [Gene_View]  chr17:3923869-3964464 [Contig_View]  ATP2A3 [Vega]
ICGC DataPortalENSG00000074370
TCGA cBioPortalATP2A3
AceView (NCBI)ATP2A3
Genatlas (Paris)ATP2A3
WikiGenes489
SOURCE (Princeton)ATP2A3
Genetics Home Reference (NIH)ATP2A3
Genomic and cartography
GoldenPath hg38 (UCSC)ATP2A3  -     chr17:3923869-3964464 -  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ATP2A3  -     17p13.2   [Description]    (hg19-Feb_2009)
EnsemblATP2A3 - 17p13.2 [CytoView hg19]  ATP2A3 - 17p13.2 [CytoView hg38]
Mapping of homologs : NCBIATP2A3 [Mapview hg19]  ATP2A3 [Mapview hg38]
OMIM601929   
Gene and transcription
Genbank (Entrez)AA643105 AF068220 AF068221 AF458228 AF458229
RefSeq transcript (Entrez)NM_005173 NM_174953 NM_174954 NM_174955 NM_174956 NM_174957 NM_174958
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ATP2A3
Cluster EST : UnigeneHs.513870 [ NCBI ]
CGAP (NCI)Hs.513870
Alternative Splicing GalleryENSG00000074370
Gene ExpressionATP2A3 [ NCBI-GEO ]   ATP2A3 [ EBI - ARRAY_EXPRESS ]   ATP2A3 [ SEEK ]   ATP2A3 [ MEM ]
Gene Expression Viewer (FireBrowse)ATP2A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)489
GTEX Portal (Tissue expression)ATP2A3
Human Protein AtlasENSG00000074370-ATP2A3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93084   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ93084  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93084
Splice isoforms : SwissVarQ93084
Catalytic activity : Enzyme3.6.3.8 [ Enzyme-Expasy ]   3.6.3.83.6.3.8 [ IntEnz-EBI ]   3.6.3.8 [ BRENDA ]   3.6.3.8 [ KEGG ]   
PhosPhoSitePlusQ93084
Domaine pattern : Prosite (Expaxy)ATPASE_E1_E2 (PS00154)   
Domains : Interpro (EBI)ATPase_P-typ_cation-transptr_C    ATPase_P-typ_cation-transptr_N    ATPase_P-typ_cyto_domN    ATPase_P-typ_P_site    ATPase_P-typ_TM_dom    ATPase_P-typ_transduc_dom_A    HAD-like_dom    P-type_ATPase_IIA    P_typ_ATPase    SERCA3   
Domain families : Pfam (Sanger)Cation_ATPase_C (PF00689)    Cation_ATPase_N (PF00690)    E1-E2_ATPase (PF00122)    Hydrolase_3 (PF08282)   
Domain families : Pfam (NCBI)pfam00689    pfam00690    pfam00122    pfam08282   
Domain families : Smart (EMBL)Cation_ATPase_N (SM00831)  
Conserved Domain (NCBI)ATP2A3
DMDM Disease mutations489
Blocks (Seattle)ATP2A3
SuperfamilyQ93084
Human Protein Atlas [tissue]ENSG00000074370-ATP2A3 [tissue]
Peptide AtlasQ93084
HPRD03568
IPIIPI00004092   IPI00748794   IPI00218440   IPI00478023   IPI00871568   IPI00218442   IPI00303760   IPI01010541   
Protein Interaction databases
DIP (DOE-UCLA)Q93084
IntAct (EBI)Q93084
FunCoupENSG00000074370
BioGRIDATP2A3
STRING (EMBL)ATP2A3
ZODIACATP2A3
Ontologies - Pathways
QuickGOQ93084
Ontology : AmiGOcalcium-transporting ATPase activity  ATP binding  endoplasmic reticulum  endoplasmic reticulum membrane  transport  calcium ion transport  integral component of membrane  sarcoplasmic reticulum  platelet dense tubular network membrane  nuclear membrane  sarcoplasmic reticulum membrane  ion transmembrane transport  metal ion binding  calcium ion transmembrane transport  ATP hydrolysis coupled cation transmembrane transport  regulation of cardiac conduction  
Ontology : EGO-EBIcalcium-transporting ATPase activity  ATP binding  endoplasmic reticulum  endoplasmic reticulum membrane  transport  calcium ion transport  integral component of membrane  sarcoplasmic reticulum  platelet dense tubular network membrane  nuclear membrane  sarcoplasmic reticulum membrane  ion transmembrane transport  metal ion binding  calcium ion transmembrane transport  ATP hydrolysis coupled cation transmembrane transport  regulation of cardiac conduction  
Pathways : KEGGCalcium signaling pathway    Pancreatic secretion    Alzheimer's disease   
NDEx NetworkATP2A3
Atlas of Cancer Signalling NetworkATP2A3
Wikipedia pathwaysATP2A3
Orthology - Evolution
OrthoDB489
GeneTree (enSembl)ENSG00000074370
Phylogenetic Trees/Animal Genes : TreeFamATP2A3
HOVERGENQ93084
HOGENOMQ93084
Homologs : HomoloGeneATP2A3
Homology/Alignments : Family Browser (UCSC)ATP2A3
Gene fusions - Rearrangements
Fusion : MitelmanATP2A3/FGF3 [17p13.2/11q13.3]  
Fusion : MitelmanUSP22/ATP2A3 [17p11.2/17p13.2]  [t(17;17)(p11;p13)]  
Fusion: TCGA_MDACCATP2A3 17p13.2 FGF3 11q13.3 BRCA
Fusion: TCGA_MDACCUSP22 17p11.2 ATP2A3 17p13.2 PRAD
Tumor Fusion PortalATP2A3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATP2A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATP2A3
dbVarATP2A3
ClinVarATP2A3
1000_GenomesATP2A3 
Exome Variant ServerATP2A3
ExAC (Exome Aggregation Consortium)ENSG00000074370
GNOMAD BrowserENSG00000074370
Genetic variants : HAPMAP489
Genomic Variants (DGV)ATP2A3 [DGVbeta]
DECIPHERATP2A3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisATP2A3 
Mutations
ICGC Data PortalATP2A3 
TCGA Data PortalATP2A3 
Broad Tumor PortalATP2A3
OASIS PortalATP2A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATP2A3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDATP2A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATP2A3
DgiDB (Drug Gene Interaction Database)ATP2A3
DoCM (Curated mutations)ATP2A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATP2A3 (select a term)
intoGenATP2A3
Cancer3DATP2A3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601929   
Orphanet
DisGeNETATP2A3
MedgenATP2A3
Genetic Testing Registry ATP2A3
NextProtQ93084 [Medical]
TSGene489
GENETestsATP2A3
Target ValidationATP2A3
Huge Navigator ATP2A3 [HugePedia]
snp3D : Map Gene to Disease489
BioCentury BCIQATP2A3
ClinGenATP2A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD489
Chemical/Pharm GKB GenePA25106
Clinical trialATP2A3
Miscellaneous
canSAR (ICR)ATP2A3 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATP2A3
EVEXATP2A3
GoPubMedATP2A3
iHOPATP2A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:04:11 CET 2017

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