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ATP2B2 (ATPase plasma membrane Ca2+ transporting 2)

Identity

Other namesPMCA2
PMCA2a
PMCA2i
HGNC (Hugo) ATP2B2
LocusID (NCBI) 491
Atlas_Id 43952
Location 3p25.3  [Link to chromosome band 3p25]
Location_base_pair Starts at 10365707 and ends at 10547268 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ABCA2 (9q34.3) / ATP2B2 (3p25.3)S100A13 (1q21.3) / ATP2B2 (3p25.3)SRGAP3 (3p25.3) / ATP2B2 (3p25.3)
SRGAP3 3p25.3 / ATP2B2 3p25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ATP2B2   815
Cards
Entrez_Gene (NCBI)ATP2B2  491  ATPase plasma membrane Ca2+ transporting 2
AliasesPMCA2; PMCA2a; PMCA2i
GeneCards (Weizmann)ATP2B2
Ensembl hg19 (Hinxton)ENSG00000157087 [Gene_View]  chr3:10365707-10547268 [Contig_View]  ATP2B2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000157087 [Gene_View]  chr3:10365707-10547268 [Contig_View]  ATP2B2 [Vega]
ICGC DataPortalENSG00000157087
TCGA cBioPortalATP2B2
AceView (NCBI)ATP2B2
Genatlas (Paris)ATP2B2
WikiGenes491
SOURCE (Princeton)ATP2B2
Genomic and cartography
GoldenPath hg19 (UCSC)ATP2B2  -     chr3:10365707-10547268 -  3p25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ATP2B2  -     3p25.3   [Description]    (hg38-Dec_2013)
EnsemblATP2B2 - 3p25.3 [CytoView hg19]  ATP2B2 - 3p25.3 [CytoView hg38]
Mapping of homologs : NCBIATP2B2 [Mapview hg19]  ATP2B2 [Mapview hg38]
OMIM108733   601386   
Gene and transcription
Genbank (Entrez)AA197323 AB210008 AK308898 AL134596 BC019853
RefSeq transcript (Entrez)NM_001001331 NM_001683
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_012046 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)ATP2B2
Cluster EST : UnigeneHs.268942 [ NCBI ]
CGAP (NCI)Hs.268942
Alternative Splicing GalleryENSG00000157087
Gene ExpressionATP2B2 [ NCBI-GEO ]   ATP2B2 [ EBI - ARRAY_EXPRESS ]   ATP2B2 [ SEEK ]   ATP2B2 [ MEM ]
Gene Expression Viewer (FireBrowse)ATP2B2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)491
GTEX Portal (Tissue expression)ATP2B2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01814 (Uniprot)
NextProtQ01814  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01814
Splice isoforms : SwissVarQ01814 (Swissvar)
Catalytic activity : Enzyme3.6.3.8 [ Enzyme-Expasy ]   3.6.3.83.6.3.8 [ IntEnz-EBI ]   3.6.3.8 [ BRENDA ]   3.6.3.8 [ KEGG ]   
PhosPhoSitePlusQ01814
Domaine pattern : Prosite (Expaxy)ATPASE_E1_E2 (PS00154)   
Domains : Interpro (EBI)ATP_Ca_trans_C    ATPase_P-typ_cation-transptr_C    ATPase_P-typ_cation-transptr_N    ATPase_P-typ_cyto_domN    ATPase_P-typ_P_site    ATPase_P-typ_TM_dom    ATPase_P-typ_transduc_dom_A    HAD-like_dom    P-type_ATPase_IIB    P_typ_ATPase   
Domain families : Pfam (Sanger)ATP_Ca_trans_C (PF12424)    Cation_ATPase_C (PF00689)    Cation_ATPase_N (PF00690)    E1-E2_ATPase (PF00122)   
Domain families : Pfam (NCBI)pfam12424    pfam00689    pfam00690    pfam00122   
Domain families : Smart (EMBL)Cation_ATPase_N (SM00831)  
DMDM Disease mutations491
Blocks (Seattle)ATP2B2
SuperfamilyQ01814
Human Protein AtlasENSG00000157087
Peptide AtlasQ01814
HPRD00160
IPIIPI00009791   IPI00219293   IPI00219295   IPI00219296   IPI00219297   IPI01008870   IPI01008982   IPI00219294   IPI00827630   IPI01018624   
Protein Interaction databases
DIP (DOE-UCLA)Q01814
IntAct (EBI)Q01814
FunCoupENSG00000157087
BioGRIDATP2B2
STRING (EMBL)ATP2B2
ZODIACATP2B2
Ontologies - Pathways
QuickGOQ01814
Ontology : AmiGOcalcium-transporting ATPase activity  calcium-transporting ATPase activity  calcium-transporting ATPase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  ATP binding  ATP binding  cytoplasm  endoplasmic reticulum  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cilium  transport  calcium ion transport  organelle organization  lactation  sensory perception of sound  locomotory behavior  protein C-terminus binding  regulation of cell size  apical plasma membrane  cerebellar Purkinje cell differentiation  cerebellar granule cell differentiation  cell junction  PDZ domain binding  neuron differentiation  calcium-dependent ATPase activity  ion transmembrane transport  locomotion  serotonin metabolic process  neuronal cell body  intracellular membrane-bounded organelle  synapse  otolith mineralization  cGMP metabolic process  metal ion binding  regulation of synaptic plasticity  synapse organization  neuromuscular process controlling balance  detection of mechanical stimulus involved in sensory perception of sound  regulation of cytosolic calcium ion concentration  positive regulation of calcium ion transport  auditory receptor cell stereocilium organization  extracellular exosome  calcium ion transmembrane transport  calcium ion transmembrane transport  cochlea development  regulation of cardiac conduction  
Ontology : EGO-EBIcalcium-transporting ATPase activity  calcium-transporting ATPase activity  calcium-transporting ATPase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  ATP binding  ATP binding  cytoplasm  endoplasmic reticulum  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cilium  transport  calcium ion transport  organelle organization  lactation  sensory perception of sound  locomotory behavior  protein C-terminus binding  regulation of cell size  apical plasma membrane  cerebellar Purkinje cell differentiation  cerebellar granule cell differentiation  cell junction  PDZ domain binding  neuron differentiation  calcium-dependent ATPase activity  ion transmembrane transport  locomotion  serotonin metabolic process  neuronal cell body  intracellular membrane-bounded organelle  synapse  otolith mineralization  cGMP metabolic process  metal ion binding  regulation of synaptic plasticity  synapse organization  neuromuscular process controlling balance  detection of mechanical stimulus involved in sensory perception of sound  regulation of cytosolic calcium ion concentration  positive regulation of calcium ion transport  auditory receptor cell stereocilium organization  extracellular exosome  calcium ion transmembrane transport  calcium ion transmembrane transport  cochlea development  regulation of cardiac conduction  
Pathways : KEGGCalcium signaling pathway    Adrenergic signaling in cardiomyocytes    Salivary secretion    Pancreatic secretion   
NDEx NetworkATP2B2
Atlas of Cancer Signalling NetworkATP2B2
Wikipedia pathwaysATP2B2
Orthology - Evolution
OrthoDB491
GeneTree (enSembl)ENSG00000157087
Phylogenetic Trees/Animal Genes : TreeFamATP2B2
Homologs : HomoloGeneATP2B2
Homology/Alignments : Family Browser (UCSC)ATP2B2
Gene fusions - Rearrangements
Fusion: TCGASRGAP3 3p25.3 ATP2B2 3p25.3 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerATP2B2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATP2B2
dbVarATP2B2
ClinVarATP2B2
1000_GenomesATP2B2 
Exome Variant ServerATP2B2
ExAC (Exome Aggregation Consortium)ATP2B2 (select the gene name)
Genetic variants : HAPMAP491
Genomic Variants (DGV)ATP2B2 [DGVbeta]
Mutations
ICGC Data PortalATP2B2 
TCGA Data PortalATP2B2 
Broad Tumor PortalATP2B2
OASIS PortalATP2B2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATP2B2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATP2B2
DgiDB (Drug Gene Interaction Database)ATP2B2
DoCM (Curated mutations)ATP2B2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATP2B2 (select a term)
intoGenATP2B2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:10365707-10547268  ENSG00000157087
CONAN: Copy Number AnalysisATP2B2 
Mutations and Diseases : HGMDATP2B2
OMIM108733    601386   
MedgenATP2B2
Genetic Testing Registry ATP2B2
NextProtQ01814 [Medical]
TSGene491
GENETestsATP2B2
Huge Navigator ATP2B2 [HugePedia]
snp3D : Map Gene to Disease491
BioCentury BCIQATP2B2
ClinGenATP2B2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD491
Chemical/Pharm GKB GenePA25108
Clinical trialATP2B2
Miscellaneous
canSAR (ICR)ATP2B2 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATP2B2
EVEXATP2B2
GoPubMedATP2B2
iHOPATP2B2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:37:51 CEST 2016

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