ATP2C2 (ATPase secretory pathway Ca2+ transporting 2)

2010-10-01  

Identity

HGNC
ATP2C2
LOCATION
16q24.1
LOCUSID
9914
ALIAS
SPCA2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9914
MIM: 613082
HGNC: 29103
Ensembl: ENSG00000064270

Variants:

dbSNP: 9914
ClinVar: 9914
TCGA: ENSG00000064270
COSMIC: ATP2C2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064270ENST00000262429O75185
ENSG00000064270ENST00000416219O75185
ENSG00000064270ENST00000569207H3BS90

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208878942010Store-independent activation of Orai1 by SPCA2 in mammary tumors.92
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
196466772009CMIP and ATP2C2 modulate phonological short-term memory in language impairment.61
158314962005The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions.37
156774512005A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brain.36
186769882008A high-density association screen of 155 ion transport genes for involvement with common migraine.22
163326772006Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.16
254483222015Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders.13
276926652017SPCA2 couples Ca2+ influx via Orai1 to Ca2+ uptake into the Golgi/secretory pathway.9
286181032017Secretory pathway Ca2+ -ATPases promote in vitro microcalcifications in breast cancer cells.9

Citation

Dessen P

ATP2C2 (ATPase secretory pathway Ca2+ transporting 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51703/atp2c2