Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ATP2C2 (ATPase secretory pathway Ca2+ transporting 2)

Identity

Alias_namesATPase, Ca++ transporting, type 2C, member 2
Alias_symbol (synonym)KIAA0703
SPCA2
Other alias
HGNC (Hugo) ATP2C2
LocusID (NCBI) 9914
Atlas_Id 51703
Location 16q24.1  [Link to chromosome band 16q24]
Location_base_pair Starts at 84368523 and ends at 84464187 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP2C2 (16q24.1) / ATP2C2 (16q24.1)ATP2C2 (16q24.1) / EIF3A (10q26.11)SMARCD1 (12q13.12) / ATP2C2 (16q24.1)
USP10 (16q24.1) / ATP2C2 (16q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dup(16)(q24q24) USP10/ATP2C2

External links

Nomenclature
HGNC (Hugo)ATP2C2   29103
Cards
Entrez_Gene (NCBI)ATP2C2  9914  ATPase secretory pathway Ca2+ transporting 2
AliasesSPCA2
GeneCards (Weizmann)ATP2C2
Ensembl hg19 (Hinxton)ENSG00000064270 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000064270 [Gene_View]  ENSG00000064270 [Sequence]  chr16:84368523-84464187 [Contig_View]  ATP2C2 [Vega]
ICGC DataPortalENSG00000064270
TCGA cBioPortalATP2C2
AceView (NCBI)ATP2C2
Genatlas (Paris)ATP2C2
WikiGenes9914
SOURCE (Princeton)ATP2C2
Genetics Home Reference (NIH)ATP2C2
Genomic and cartography
GoldenPath hg38 (UCSC)ATP2C2  -     chr16:84368523-84464187 +  16q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ATP2C2  -     16q24.1   [Description]    (hg19-Feb_2009)
GoldenPathATP2C2 - 16q24.1 [CytoView hg19]  ATP2C2 - 16q24.1 [CytoView hg38]
ImmunoBaseENSG00000064270
Mapping of homologs : NCBIATP2C2 [Mapview hg19]  ATP2C2 [Mapview hg38]
OMIM613082   
Gene and transcription
Genbank (Entrez)AB014603 AK025424 AK091051 AK092737 AK300526
RefSeq transcript (Entrez)NM_001286527 NM_001291454 NM_014861
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ATP2C2
Cluster EST : UnigeneHs.6168 [ NCBI ]
CGAP (NCI)Hs.6168
Alternative Splicing GalleryENSG00000064270
Gene ExpressionATP2C2 [ NCBI-GEO ]   ATP2C2 [ EBI - ARRAY_EXPRESS ]   ATP2C2 [ SEEK ]   ATP2C2 [ MEM ]
Gene Expression Viewer (FireBrowse)ATP2C2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9914
GTEX Portal (Tissue expression)ATP2C2
Human Protein AtlasENSG00000064270-ATP2C2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75185   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75185  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75185
Splice isoforms : SwissVarO75185
Catalytic activity : Enzyme3.6.3.8 [ Enzyme-Expasy ]   3.6.3.83.6.3.8 [ IntEnz-EBI ]   3.6.3.8 [ BRENDA ]   3.6.3.8 [ KEGG ]   
PhosPhoSitePlusO75185
Domaine pattern : Prosite (Expaxy)ATPASE_E1_E2 (PS00154)   
Domains : Interpro (EBI)ATP2C2    ATPase_P-typ_cation-transptr_C    ATPase_P-typ_cation-transptr_N    ATPase_P-typ_cyto_dom_N    ATPase_P-typ_P_site    ATPase_P-typ_TM_dom_sf    ATPase_P-typ_transduc_dom_A_sf    HAD-like_sf    HAD_sf    P-type_ATPase_IIA_PMR1    P_typ_ATPase   
Domain families : Pfam (Sanger)Cation_ATPase_C (PF00689)    Cation_ATPase_N (PF00690)   
Domain families : Pfam (NCBI)pfam00689    pfam00690   
Domain families : Smart (EMBL)Cation_ATPase_N (SM00831)  
Conserved Domain (NCBI)ATP2C2
DMDM Disease mutations9914
Blocks (Seattle)ATP2C2
SuperfamilyO75185
Human Protein Atlas [tissue]ENSG00000064270-ATP2C2 [tissue]
Peptide AtlasO75185
HPRD13812
IPIIPI00006653   IPI00915432   IPI00872635   
Protein Interaction databases
DIP (DOE-UCLA)O75185
IntAct (EBI)O75185
FunCoupENSG00000064270
BioGRIDATP2C2
STRING (EMBL)ATP2C2
ZODIACATP2C2
Ontologies - Pathways
QuickGOO75185
Ontology : AmiGOGolgi membrane  Golgi membrane  calcium-transporting ATPase activity  protein binding  ATP binding  cellular calcium ion homeostasis  proton-exporting ATPase activity, phosphorylative mechanism  cytoplasmic side of plasma membrane  manganese-transporting ATPase activity  integral component of membrane  cytoplasmic vesicle  ion transmembrane transport  metal ion binding  perinuclear region of cytoplasm  mammary gland epithelium development  calcium ion transmembrane transport  manganese ion transmembrane transport  protein localization to plasma membrane  positive regulation of calcium ion import  proton transmembrane transport  
Ontology : EGO-EBIGolgi membrane  Golgi membrane  calcium-transporting ATPase activity  protein binding  ATP binding  cellular calcium ion homeostasis  proton-exporting ATPase activity, phosphorylative mechanism  cytoplasmic side of plasma membrane  manganese-transporting ATPase activity  integral component of membrane  cytoplasmic vesicle  ion transmembrane transport  metal ion binding  perinuclear region of cytoplasm  mammary gland epithelium development  calcium ion transmembrane transport  manganese ion transmembrane transport  protein localization to plasma membrane  positive regulation of calcium ion import  proton transmembrane transport  
NDEx NetworkATP2C2
Atlas of Cancer Signalling NetworkATP2C2
Wikipedia pathwaysATP2C2
Orthology - Evolution
OrthoDB9914
GeneTree (enSembl)ENSG00000064270
Phylogenetic Trees/Animal Genes : TreeFamATP2C2
HOGENOMO75185
Homologs : HomoloGeneATP2C2
Homology/Alignments : Family Browser (UCSC)ATP2C2
Gene fusions - Rearrangements
Fusion : MitelmanUSP10/ATP2C2 [16q24.1/16q24.1]  [dup(16)(q24q24)]  
Fusion : QuiverATP2C2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATP2C2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATP2C2
dbVarATP2C2
ClinVarATP2C2
1000_GenomesATP2C2 
Exome Variant ServerATP2C2
ExAC (Exome Aggregation Consortium)ENSG00000064270
GNOMAD BrowserENSG00000064270
Varsome BrowserATP2C2
Genetic variants : HAPMAP9914
Genomic Variants (DGV)ATP2C2 [DGVbeta]
DECIPHERATP2C2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisATP2C2 
Mutations
ICGC Data PortalATP2C2 
TCGA Data PortalATP2C2 
Broad Tumor PortalATP2C2
OASIS PortalATP2C2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATP2C2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DATP2C2
Mutations and Diseases : HGMDATP2C2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATP2C2
DgiDB (Drug Gene Interaction Database)ATP2C2
DoCM (Curated mutations)ATP2C2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATP2C2 (select a term)
intoGenATP2C2
Cancer3DATP2C2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613082   
Orphanet
DisGeNETATP2C2
MedgenATP2C2
Genetic Testing Registry ATP2C2
NextProtO75185 [Medical]
TSGene9914
GENETestsATP2C2
Target ValidationATP2C2
Huge Navigator ATP2C2 [HugePedia]
snp3D : Map Gene to Disease9914
BioCentury BCIQATP2C2
ClinGenATP2C2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9914
Chemical/Pharm GKB GenePA162377204
Clinical trialATP2C2
Miscellaneous
canSAR (ICR)ATP2C2 (select the gene name)
DataMed IndexATP2C2
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATP2C2
EVEXATP2C2
GoPubMedATP2C2
iHOPATP2C2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:33:30 CET 2019
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