ATP5F1E (ATP synthase F1 subunit epsilon)

2018-02-01  

Identity

HGNC
LOCATION
20q13.32
LOCUSID
ALIAS
ATP5E,ATPE,MC5DN3

Other Information

Locus ID:

NCBI: 514
MIM: 606153
HGNC: 838
Ensembl: ENSG00000124172

Variants:

dbSNP: 514
ClinVar: 514
TCGA: ENSG00000124172
COSMIC: ATP5F1E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124172ENST00000243997P56381
ENSG00000124172ENST00000395659P56381
ENSG00000124172ENST00000395663P56381

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Metabolic pathwaysKEGGhsa01100
F-type ATPase, eukaryotesKEGGhsa_M00158
F-type ATPase, eukaryotesKEGGM00158
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Formation of ATP by chemiosmotic couplingREACTOMER-HSA-163210

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
200260072010Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase and leads to accumulation of subunit c.15
240679182013Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues.8
260798492015Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?5
190167462008Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells.4

Citation

Dessen P

ATP5F1E (ATP synthase F1 subunit epsilon)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57284/atp5f1e