ATP5PO (ATP synthase peripheral stalk subunit OSCP)

2018-11-01  

Identity

HGNC
ATP5PO
LOCATION
21q22.11
LOCUSID
539
ALIAS
ATP5O,ATPO,HMC08D05,OSCP

Other Information

Locus ID:

NCBI: 539
MIM: 600828
HGNC: 850
Ensembl: ENSG00000241837

Variants:

dbSNP: 539
ClinVar: 539
TCGA: ENSG00000241837
COSMIC: ATP5PO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241837ENST00000290299P48047
ENSG00000241837ENST00000417181H7C2P9
ENSG00000241837ENST00000418933H7C068
ENSG00000241837ENST00000429064H7C239
ENSG00000241837ENST00000431254H7C086
ENSG00000241837ENST00000652380A0A494C0K9

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Metabolic pathwaysKEGGhsa01100
F-type ATPase, eukaryotesKEGGhsa_M00158
F-type ATPase, eukaryotesKEGGM00158
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Formation of ATP by chemiosmotic couplingREACTOMER-HSA-163210

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
230468122013Regulation of mitochondrial F(o)F(1)ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA.29
268764302016The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival.28
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
121106732002A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies.8
192740822009Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins.7
192740822009Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins.7

Citation

Dessen P

ATP5PO (ATP synthase peripheral stalk subunit OSCP)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/80475/atp5po