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ATP6V0C (ATPase H+ transporting V0 subunit c)

Identity

Alias_namesATPL
ATP6C
ATP6L
ATPase, H transporting, lysosomal (vacuolar proton pump) 16kD
ATPase, H transporting, lysosomal 16kDa, V0 subunit c
Alias_symbol (synonym)VATL
Vma3
Other aliasVPPC
HGNC (Hugo) ATP6V0C
LocusID (NCBI) 527
Atlas_Id 50975
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 2563727 and ends at 2570224 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AMDHD2 (16p13.3) / ATP6V0C (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ATP6V0C   855
Cards
Entrez_Gene (NCBI)ATP6V0C  527  ATPase H+ transporting V0 subunit c
AliasesATP6C; ATP6L; ATPL; VATL; 
VPPC; Vma3
GeneCards (Weizmann)ATP6V0C
Ensembl hg19 (Hinxton)ENSG00000185883 [Gene_View]  chr16:2563727-2570224 [Contig_View]  ATP6V0C [Vega]
Ensembl hg38 (Hinxton)ENSG00000185883 [Gene_View]  chr16:2563727-2570224 [Contig_View]  ATP6V0C [Vega]
ICGC DataPortalENSG00000185883
TCGA cBioPortalATP6V0C
AceView (NCBI)ATP6V0C
Genatlas (Paris)ATP6V0C
WikiGenes527
SOURCE (Princeton)ATP6V0C
Genetics Home Reference (NIH)ATP6V0C
Genomic and cartography
GoldenPath hg19 (UCSC)ATP6V0C  -     chr16:2563727-2570224 +  16p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ATP6V0C  -     16p13.3   [Description]    (hg38-Dec_2013)
EnsemblATP6V0C - 16p13.3 [CytoView hg19]  ATP6V0C - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIATP6V0C [Mapview hg19]  ATP6V0C [Mapview hg38]
OMIM108745   
Gene and transcription
Genbank (Entrez)AW161158 BC004537 BC007389 BC007759 BC009290
RefSeq transcript (Entrez)NM_001198569 NM_001694
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010393 NW_004929400
Consensus coding sequences : CCDS (NCBI)ATP6V0C
Cluster EST : UnigeneHs.389107 [ NCBI ]
CGAP (NCI)Hs.389107
Alternative Splicing GalleryENSG00000185883
Gene ExpressionATP6V0C [ NCBI-GEO ]   ATP6V0C [ EBI - ARRAY_EXPRESS ]   ATP6V0C [ SEEK ]   ATP6V0C [ MEM ]
Gene Expression Viewer (FireBrowse)ATP6V0C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)527
GTEX Portal (Tissue expression)ATP6V0C
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27449   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27449  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27449
Splice isoforms : SwissVarP27449
PhosPhoSitePlusP27449
Domains : Interpro (EBI)ATPase_proteolipid_c-like_dom    ATPase_proteolipid_csu    ATPase_proteolipid_su_C_euk   
Domain families : Pfam (Sanger)ATP-synt_C (PF00137)   
Domain families : Pfam (NCBI)pfam00137   
Conserved Domain (NCBI)ATP6V0C
DMDM Disease mutations527
Blocks (Seattle)ATP6V0C
SuperfamilyP27449
Human Protein AtlasENSG00000185883
Peptide AtlasP27449
HPRD00162
IPIIPI00018855   IPI00978029   
Protein Interaction databases
DIP (DOE-UCLA)P27449
IntAct (EBI)P27449
FunCoupENSG00000185883
BioGRIDATP6V0C
STRING (EMBL)ATP6V0C
ZODIACATP6V0C
Ontologies - Pathways
QuickGOP27449
Ontology : AmiGOvacuolar proton-transporting V-type ATPase, V0 domain  protein binding  lysosomal membrane  focal adhesion  lysosomal lumen acidification  insulin receptor signaling pathway  endosome membrane  ATP hydrolysis coupled proton transport  proton transport  integral component of membrane  viral process  regulation of macroautophagy  positive regulation of Wnt signaling pathway  phagocytic vesicle membrane  ubiquitin protein ligase binding  transferrin transport  ion transmembrane transport  proton-transporting ATP synthase activity, rotational mechanism  proton-transporting ATPase activity, rotational mechanism  extracellular exosome  phagosome acidification  
Ontology : EGO-EBIvacuolar proton-transporting V-type ATPase, V0 domain  protein binding  lysosomal membrane  focal adhesion  lysosomal lumen acidification  insulin receptor signaling pathway  endosome membrane  ATP hydrolysis coupled proton transport  proton transport  integral component of membrane  viral process  regulation of macroautophagy  positive regulation of Wnt signaling pathway  phagocytic vesicle membrane  ubiquitin protein ligase binding  transferrin transport  ion transmembrane transport  proton-transporting ATP synthase activity, rotational mechanism  proton-transporting ATPase activity, rotational mechanism  extracellular exosome  phagosome acidification  
Pathways : KEGGOxidative phosphorylation    Lysosome    Phagosome    Synaptic vesicle cycle    Collecting duct acid secretion    Vibrio cholerae infection    Epithelial cell signaling in Helicobacter pylori infection    Tuberculosis    Rheumatoid arthritis   
NDEx NetworkATP6V0C
Atlas of Cancer Signalling NetworkATP6V0C
Wikipedia pathwaysATP6V0C
Orthology - Evolution
OrthoDB527
GeneTree (enSembl)ENSG00000185883
Phylogenetic Trees/Animal Genes : TreeFamATP6V0C
HOVERGENP27449
HOGENOMP27449
Homologs : HomoloGeneATP6V0C
Homology/Alignments : Family Browser (UCSC)ATP6V0C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATP6V0C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATP6V0C
dbVarATP6V0C
ClinVarATP6V0C
1000_GenomesATP6V0C 
Exome Variant ServerATP6V0C
ExAC (Exome Aggregation Consortium)ATP6V0C (select the gene name)
Genetic variants : HAPMAP527
Genomic Variants (DGV)ATP6V0C [DGVbeta]
DECIPHER (Syndromes)16:2563727-2570224  ENSG00000185883
CONAN: Copy Number AnalysisATP6V0C 
Mutations
ICGC Data PortalATP6V0C 
TCGA Data PortalATP6V0C 
Broad Tumor PortalATP6V0C
OASIS PortalATP6V0C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATP6V0C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDATP6V0C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATP6V0C
DgiDB (Drug Gene Interaction Database)ATP6V0C
DoCM (Curated mutations)ATP6V0C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATP6V0C (select a term)
intoGenATP6V0C
Cancer3DATP6V0C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108745   
Orphanet
MedgenATP6V0C
Genetic Testing Registry ATP6V0C
NextProtP27449 [Medical]
TSGene527
GENETestsATP6V0C
Huge Navigator ATP6V0C [HugePedia]
snp3D : Map Gene to Disease527
BioCentury BCIQATP6V0C
ClinGenATP6V0C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD527
Chemical/Pharm GKB GenePA25149
Clinical trialATP6V0C
Miscellaneous
canSAR (ICR)ATP6V0C (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATP6V0C
EVEXATP6V0C
GoPubMedATP6V0C
iHOPATP6V0C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:53:28 CEST 2017

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