Atlas of Genetics and Cytogenetics in Oncology and Haematology


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AURKC (aurora kinase C)

Identity

Alias (NCBI)AIE2
AIK3
ARK3
AurC
HEL-S-90
SPGF5
STK13
aurora-C
HGNC (Hugo) AURKC
HGNC Alias symbAurC
ARK3
HGNC Previous nameSTK13
HGNC Previous nameserine/threonine kinase 13 (aurora/IPL1-like)
LocusID (NCBI) 6795
Atlas_Id 46007
Location 19q13.43  [Link to chromosome band 19q13]
Location_base_pair Starts at 57231023 and ends at 57235548 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP6R1 (19q13.42)::AURKC (19q13.43)PPP6R1 19q13.42::AURKC 19q13.43

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)AURKC   11391
Cards
Entrez_Gene (NCBI)AURKC    aurora kinase C
AliasesAIE2; AIK3; ARK3; AurC; 
HEL-S-90; SPGF5; STK13; aurora-C
GeneCards (Weizmann)AURKC
Ensembl hg19 (Hinxton)ENSG00000105146 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105146 [Gene_View]  ENSG00000105146 [Sequence]  chr19:57231023-57235548 [Contig_View]  AURKC [Vega]
ICGC DataPortalENSG00000105146
TCGA cBioPortalAURKC
AceView (NCBI)AURKC
Genatlas (Paris)AURKC
SOURCE (Princeton)AURKC
Genetics Home Reference (NIH)AURKC
Genomic and cartography
GoldenPath hg38 (UCSC)AURKC  -     chr19:57231023-57235548 +  19q13.43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AURKC  -     19q13.43   [Description]    (hg19-Feb_2009)
GoldenPathAURKC - 19q13.43 [CytoView hg19]  AURKC - 19q13.43 [CytoView hg38]
ImmunoBaseENSG00000105146
Genome Data Viewer NCBIAURKC [Mapview hg19]  
OMIM243060   603495   
Gene and transcription
Genbank (Entrez)AB017332 AF054621 AF059681 AK301886 AY661554
RefSeq transcript (Entrez)NM_001015878 NM_001015879 NM_003160
Consensus coding sequences : CCDS (NCBI)AURKC
Gene ExpressionAURKC [ NCBI-GEO ]   AURKC [ EBI - ARRAY_EXPRESS ]   AURKC [ SEEK ]   AURKC [ MEM ]
Gene Expression Viewer (FireBrowse)AURKC [ Firebrowse - Broad ]
GenevisibleExpression of AURKC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6795
GTEX Portal (Tissue expression)AURKC
Human Protein AtlasENSG00000105146-AURKC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQB9
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UQB9
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Aur    AURKC    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)AURKC
PDB (RSDB)6GR8    6GR9   
PDB Europe6GR8    6GR9   
PDB (PDBSum)6GR8    6GR9   
PDB (IMB)6GR8    6GR9   
Structural Biology KnowledgeBase6GR8    6GR9   
SCOP (Structural Classification of Proteins)6GR8    6GR9   
CATH (Classification of proteins structures)6GR8    6GR9   
SuperfamilyQ9UQB9
AlphaFold pdb e-kbQ9UQB9   
Human Protein Atlas [tissue]ENSG00000105146-AURKC [tissue]
HPRD04605
Protein Interaction databases
DIP (DOE-UCLA)Q9UQB9
IntAct (EBI)Q9UQB9
BioGRIDAURKC
STRING (EMBL)AURKC
ZODIACAURKC
Ontologies - Pathways
QuickGOQ9UQB9
Ontology : AmiGOchromosome, centromeric region  condensed chromosome  protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  spindle  spindle microtubule  protein phosphorylation  mitotic spindle organization  spermatogenesis  attachment of spindle microtubules to kinetochore  histone modification  midbody  midbody  spindle pole centrosome  chromosome passenger complex  chromosome passenger complex  regulation of cytokinesis  positive regulation of cytokinesis  histone serine kinase activity  histone-serine phosphorylation  oocyte development  spindle midzone  spindle midzone  mitotic spindle midzone assembly  cell division  meiotic cell cycle  protein serine kinase activity  
Ontology : EGO-EBIchromosome, centromeric region  condensed chromosome  protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  spindle  spindle microtubule  protein phosphorylation  mitotic spindle organization  spermatogenesis  attachment of spindle microtubules to kinetochore  histone modification  midbody  midbody  spindle pole centrosome  chromosome passenger complex  chromosome passenger complex  regulation of cytokinesis  positive regulation of cytokinesis  histone serine kinase activity  histone-serine phosphorylation  oocyte development  spindle midzone  spindle midzone  mitotic spindle midzone assembly  cell division  meiotic cell cycle  protein serine kinase activity  
NDEx NetworkAURKC
Atlas of Cancer Signalling NetworkAURKC
Wikipedia pathwaysAURKC
Orthology - Evolution
OrthoDB6795
GeneTree (enSembl)ENSG00000105146
Phylogenetic Trees/Animal Genes : TreeFamAURKC
Homologs : HomoloGeneAURKC
Homology/Alignments : Family Browser (UCSC)AURKC
Gene fusions - Rearrangements
Fusion : MitelmanPPP6R1::AURKC [19q13.42/19q13.43]  
Fusion : QuiverAURKC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAURKC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AURKC
dbVarAURKC
ClinVarAURKC
MonarchAURKC
1000_GenomesAURKC 
Exome Variant ServerAURKC
GNOMAD BrowserENSG00000105146
Varsome BrowserAURKC
ACMGAURKC variants
VarityQ9UQB9
Genomic Variants (DGV)AURKC [DGVbeta]
DECIPHERAURKC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAURKC 
Mutations
ICGC Data PortalAURKC 
TCGA Data PortalAURKC 
Broad Tumor PortalAURKC
OASIS PortalAURKC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAURKC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAURKC
Mutations and Diseases : HGMDAURKC
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaAURKC
DgiDB (Drug Gene Interaction Database)AURKC
DoCM (Curated mutations)AURKC
CIViC (Clinical Interpretations of Variants in Cancer)AURKC
Cancer3DAURKC
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM243060    603495   
Orphanet16738   
DisGeNETAURKC
MedgenAURKC
Genetic Testing Registry AURKC
NextProtQ9UQB9 [Medical]
GENETestsAURKC
Target ValidationAURKC
Huge Navigator AURKC [HugePedia]
ClinGenAURKC
Clinical trials, drugs, therapy
MyCancerGenomeAURKC
Protein Interactions : CTDAURKC
Pharm GKB GenePA36200
PharosQ9UQB9
Clinical trialAURKC
Miscellaneous
canSAR (ICR)AURKC
HarmonizomeAURKC
ARCHS4AURKC
DataMed IndexAURKC
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXAURKC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:23:57 CET 2022

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