Atlas of Genetics and Cytogenetics in Oncology and Haematology


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AURKC (aurora kinase C)

Identity

Alias_namesSTK13
serine/threonine kinase 13 (aurora/IPL1-like)
Alias_symbol (synonym)AurC
ARK3
Other aliasAIE2
AIK3
HEL-S-90
SPGF5
aurora-C
HGNC (Hugo) AURKC
LocusID (NCBI) 6795
Atlas_Id 46007
Location 19q13.43  [Link to chromosome band 19q13]
Location_base_pair Starts at 57231060 and ends at 57235548 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPP6R1 (19q13.42) / AURKC (19q13.43)PPP6R1 19q13.42 / AURKC 19q13.43

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AURKC   11391
Cards
Entrez_Gene (NCBI)AURKC  6795  aurora kinase C
AliasesAIE2; AIK3; ARK3; AurC; 
HEL-S-90; SPGF5; STK13; aurora-C
GeneCards (Weizmann)AURKC
Ensembl hg19 (Hinxton)ENSG00000105146 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105146 [Gene_View]  chr19:57231060-57235548 [Contig_View]  AURKC [Vega]
ICGC DataPortalENSG00000105146
TCGA cBioPortalAURKC
AceView (NCBI)AURKC
Genatlas (Paris)AURKC
WikiGenes6795
SOURCE (Princeton)AURKC
Genetics Home Reference (NIH)AURKC
Genomic and cartography
GoldenPath hg38 (UCSC)AURKC  -     chr19:57231060-57235548 +  19q13.43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AURKC  -     19q13.43   [Description]    (hg19-Feb_2009)
EnsemblAURKC - 19q13.43 [CytoView hg19]  AURKC - 19q13.43 [CytoView hg38]
Mapping of homologs : NCBIAURKC [Mapview hg19]  AURKC [Mapview hg38]
OMIM243060   603495   
Gene and transcription
Genbank (Entrez)AB017332 AF054621 AF059681 AK301886 AY661554
RefSeq transcript (Entrez)NM_001015878 NM_001015879 NM_003160
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AURKC
Cluster EST : UnigeneHs.98338 [ NCBI ]
CGAP (NCI)Hs.98338
Alternative Splicing GalleryENSG00000105146
Gene ExpressionAURKC [ NCBI-GEO ]   AURKC [ EBI - ARRAY_EXPRESS ]   AURKC [ SEEK ]   AURKC [ MEM ]
Gene Expression Viewer (FireBrowse)AURKC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6795
GTEX Portal (Tissue expression)AURKC
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQB9
Splice isoforms : SwissVarQ9UQB9
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9UQB9
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Aur    AURKC    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)AURKC
DMDM Disease mutations6795
Blocks (Seattle)AURKC
SuperfamilyQ9UQB9
Human Protein AtlasENSG00000105146
Peptide AtlasQ9UQB9
HPRD04605
IPIIPI00099756   IPI00332343   IPI00555808   
Protein Interaction databases
DIP (DOE-UCLA)Q9UQB9
IntAct (EBI)Q9UQB9
FunCoupENSG00000105146
BioGRIDAURKC
STRING (EMBL)AURKC
ZODIACAURKC
Ontologies - Pathways
QuickGOQ9UQB9
Ontology : AmiGOcondensed nuclear chromosome, centromeric region  condensed chromosome  cytokinesis  protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  cytoplasm  spindle  spindle microtubule  protein phosphorylation  spermatogenesis  attachment of spindle microtubules to kinetochore  histone modification  midbody  midbody  spindle pole centrosome  chromosome passenger complex  positive regulation of cytokinesis  histone serine kinase activity  histone-serine phosphorylation  oocyte development  spindle midzone  mitotic spindle midzone assembly  meiotic cell cycle  
Ontology : EGO-EBIcondensed nuclear chromosome, centromeric region  condensed chromosome  cytokinesis  protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  cytoplasm  spindle  spindle microtubule  protein phosphorylation  spermatogenesis  attachment of spindle microtubules to kinetochore  histone modification  midbody  midbody  spindle pole centrosome  chromosome passenger complex  positive regulation of cytokinesis  histone serine kinase activity  histone-serine phosphorylation  oocyte development  spindle midzone  mitotic spindle midzone assembly  meiotic cell cycle  
NDEx NetworkAURKC
Atlas of Cancer Signalling NetworkAURKC
Wikipedia pathwaysAURKC
Orthology - Evolution
OrthoDB6795
GeneTree (enSembl)ENSG00000105146
Phylogenetic Trees/Animal Genes : TreeFamAURKC
HOVERGENQ9UQB9
HOGENOMQ9UQB9
Homologs : HomoloGeneAURKC
Homology/Alignments : Family Browser (UCSC)AURKC
Gene fusions - Rearrangements
Fusion : MitelmanPPP6R1/AURKC [19q13.42/19q13.43]  [t(19;19)(q13;q13)]  
Fusion: TCGAPPP6R1 19q13.42 AURKC 19q13.43 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAURKC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AURKC
dbVarAURKC
ClinVarAURKC
1000_GenomesAURKC 
Exome Variant ServerAURKC
ExAC (Exome Aggregation Consortium)AURKC (select the gene name)
Genetic variants : HAPMAP6795
Genomic Variants (DGV)AURKC [DGVbeta]
DECIPHERAURKC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAURKC 
Mutations
ICGC Data PortalAURKC 
TCGA Data PortalAURKC 
Broad Tumor PortalAURKC
OASIS PortalAURKC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAURKC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAURKC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AURKC
DgiDB (Drug Gene Interaction Database)AURKC
DoCM (Curated mutations)AURKC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AURKC (select a term)
intoGenAURKC
Cancer3DAURKC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM243060    603495   
Orphanet16738   
MedgenAURKC
Genetic Testing Registry AURKC
NextProtQ9UQB9 [Medical]
TSGene6795
GENETestsAURKC
Target ValidationAURKC
Huge Navigator AURKC [HugePedia]
snp3D : Map Gene to Disease6795
BioCentury BCIQAURKC
ClinGenAURKC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6795
Chemical/Pharm GKB GenePA36200
Clinical trialAURKC
Miscellaneous
canSAR (ICR)AURKC (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAURKC
EVEXAURKC
GoPubMedAURKC
iHOPAURKC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:55:48 CEST 2017

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