AZGP1 (alpha-2-glycoprotein 1, zinc-binding)

2003-08-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
ZA2G,ZAG
FUSION GENES

Other Information

Locus ID:

NCBI: 563
MIM: 194460
HGNC: 910
Ensembl: ENSG00000160862

Variants:

dbSNP: 563
ClinVar: 563
TCGA: ENSG00000160862
COSMIC: AZGP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160862ENST00000292401P25311
ENSG00000160862ENST00000292401A0A140VK00
ENSG00000160862ENST00000411734C9JEV0
ENSG00000160862ENST00000419575H7BZJ8

Expression (GTEx)

0
500
1000
1500
2000
2500
3000

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Miscellaneous transport and binding eventsREACTOMER-HSA-5223345

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
149830382004Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia.55
185677942008Zinc alpha 2-glycoprotein: a multidisciplinary protein.52
214432012011Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling.46
156206882005Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes.37
195492462010The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity.33
196226242009Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance.28
212458622011Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients.27
241147352014Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma.27
205818622010AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-β-mediated ERK signaling.26
189785572008AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma.21

Citation

Dessen P

AZGP1 (alpha-2-glycoprotein 1, zinc-binding)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/735/azgp1